Biosynthesizing Cassia fistula Extract-Mediated Silver Nanoparticles for MCF-7 Cell Lines Anti-Cancer Assay

Abstract

The unique consequence of green synthesis is that the mediator plant is able to release chemicals that are efficacious as reducing as well as stabilizing agents. In this work, the fruit pulp and leaf essences of Cassia fistula have been used to manufacture silver nanoparticles through the green synthesis technique. The sculpturing of nanoparticles was accomplished by utilizing the reduction phenomenon that ensued due to the reaction between plant essences and the precursor solution. These biosynthesized silver nanoparticles were examined, where we used scanning electron microscopy, UV−vis spectroscopy, and X-ray diffraction techniques as means to analyze the structure, optical properties, and crystalline behavior, respectively. The absorption spectra for fruit and leaf extracts obtained from the UV−vis analyses peaked at 401 and 397 nm, and these peaks imply the appearance of optical energy gaps of 2.12 and 2.58 eV, accompanying spherical shapes of particles with diameters in the ranges of 12−20 and 50−80 nm, respectively. These silver nanoparticles together with the adopted green technique have a vast array of applications, specifically in the biomedical realm. In particular, they are being used to treat several diseases and are manifested as strong anti-tumor agents to medicate MCF-7 breast cancer cell lines in order to minimize the cell growth rate depending on their concentrations.

Synthesis of Silver Nanoparticles Using Green Reducing Agent: Ceylon Olive (Elaeocarpus serratus): Characterization and Investigating Their Antimicrobial Properties

“…Some AgNPs were found to exhibit cubic and pebble-like forms [44], depending on parameters such as pH, temperature, and extract concentration. However, small clusters of particles were observable due to the tendency of nanoparticles to agglomerate owing to their heightened surface energy, aiming to minimize surface energy [45]. Comparable outcomes were documented in the investigation of AgNP synthesis employing Annona squamosa leaf extract [46].…”