Biosynthesized tumor acidity and MMP dual-responsive plant toxin gelonin for robust cancer therapy

Ding, Guo-Bin; Cao, Huiyan; Zhu, Chenchen; Chen, Fangyuan; Ye, Jiaqi; Li, Bin-Chun; Yang, Peng; Stauber, Roland H.; Qiao, Mingqiang; Li, Zhuoyu

doi:10.1039/d3bm01779f

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2024

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“…Hyaluronidase hyaluronic acid [121] Acid & MMP pHLIP & PVGLIG [130] Acid & ROS protonated groups & thioketals [131] Acid & Hypoxia protonated groups & nitrobenzyl [132] GSH & ROS selenides & disulfide bonds [133] granules to mediate cell death. In the process, acidic granular content can induce the acidification of IS.…”

Section: Hypoxiamentioning

confidence: 99%

Nano‐Engineering Strategies for Tumor‐Specific Therapy

Li,

Xie,

Nie.

2024

ChemMedChem

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Nanodelivery systems (NDSs) provide promising prospects for decreasing drug doses, reducing side effects, and improving therapeutic effects. However, the bioapplications of NDSs are still compromised by their fast clearance, indiscriminate biodistribution, and limited tumor accumulation. Hence, engineering modification of NDSs aiming at promoting tumor‐specific therapy and avoiding systemic toxicity is usually needed. An NDS integrating various functionalities, including flexible camouflage, specific biorecognition, and sensitive stimuli‐responsiveness, into one sequence would be "smart" and highly effective. Herein, we systematically summarize the related principles, methods, and progress. At the end of the review, we predict the obstacles to precise nanoengineering and prospects for the future application of NDSs.

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