Biosynthesized silver nanoparticles using Bacillus amyloliquefaciens; Application for cytotoxicity effect on A549 cell line and photocatalytic degradation of p-nitrophenol

Samuel, Melvin S.; Jose, Sujin P.; Ethiraj, Selvarajan; Mathimani, Thangavel; Pugazhendhi, Arivalagan

doi:10.1016/j.jphotobiol.2019.111642

Cited by 154 publications

(56 citation statements)

References 60 publications

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“…3 In addition, they are low cost and have shown low cytotoxicity and immunological response. 4 Therefore, silver nanoparticles have multiple potential biomedical applications. They are used for drug delivery, medical imaging and molecular diagnostics.…”

Section: Introductionmentioning

confidence: 99%

The Antibacterial Mechanism of Silver Nanoparticles and Its Application in Dentistry

Yin¹,

Zhang²,

Zhao³

et al. 2020

IJN

958

681

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Nanotechnology has recently emerged as a rapidly growing field with numerous biomedical science applications. At the same time, silver has been adopted as an antimicrobial material and disinfectant that is relatively free of adverse effects. Silver nanoparticles possess a broad spectrum of antibacterial, antifungal and antiviral properties. Silver nanoparticles have the ability to penetrate bacterial cell walls, changing the structure of cell membranes and even resulting in cell death. Their efficacy is due not only to their nanoscale size but also to their large ratio of surface area to volume. They can increase the permeability of cell membranes, produce reactive oxygen species, and interrupt replication of deoxyribonucleic acid by releasing silver ions. Researchers have studied silver nanoparticles as antimicrobial agents in dentistry. For instance, silver nanoparticles can be incorporated into acrylic resins for fabrication of removable dentures in prosthetic treatment, composite resin in restorative treatment, irrigating solution and obturation material in endodontic treatment, adhesive materials in orthodontic treatment, membrane for guided tissue regeneration in periodontal treatment, and titanium coating in dental implant treatment. Although not all authorities have acknowledged the safety of silver nanoparticles, no systemic toxicity of ingested silver nanoparticles has been reported. A broad concern is their potential hazard if they are released into the environment. However, the interaction of nanoparticles with toxic materials and organic compounds can either increase or reduce their toxicity. This paper provides an overview of the antibacterial use of silver nanoparticles in dentistry, highlighting their antibacterial mechanism, potential applications and safety in clinical treatment.

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Section: Introductionmentioning

confidence: 99%

The Antibacterial Mechanism of Silver Nanoparticles and Its Application in Dentistry

Yin¹,

Zhang²,

Zhao³

et al. 2020

IJN

958

681

View full text Add to dashboard Cite

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“…This band is correlated to the surface plasmon absorption band, which explains the formation of the uniform, dispersed spherical AgNPs capped with mPEGTH2. 19,46 The broadness of the band decreased in intensity, with appearance of a shoulder at 375 nm, for mPEGTH2-AgNPs (AgNO 3 :mPEGTH2, 1:1) as shown in Figure 1A. This observation indicates an accumulation of AgNPs with the change in chemical structure of mPEGTH2.…”

Section: Characterization Of Agnps Ftir and Uv-spectroscopy Charactermentioning

confidence: 79%

“…Generally, the synthesis of nanoparticles has been carried out using three different approaches: Physical methods; 12,13 chemical methods using water or organic solvents; 1,14,15 and biological methods. [16][17][18][19] Chemical methods usually employ three main components, which are metal precursors, reducing agents, and stabilizing/capping agents. The major advantage of chemical methods is that they have high yields compared to that of physical methods.…”

Section: Introductionmentioning

confidence: 99%

Simple Approaches for the Synthesis of AgNPs in Solution and Solid Phase Using Modified Methoxypolyethylene Glycol and Evaluation of Their Antimicrobial Activity

El‐Faham¹,

Al-Rasheed²,

Sholkamy³

et al. 2020

IJN

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Purpose: Simple methodology for preparation of metal nanoparticles such as AgNPs uses an methanolic aqueous medium at room temperature or a solvent-free procedure under microwave irradiation. The prepared AgNPs showed a significant antimicrobial effect against Gram-positive bacteria, Gram-negative bacteria, and fungi. Methods: The modified methoxypolyethylene glycol bishydrazino-s-triazine (mPEGTH2) showed remarkable activity for reducing Ag + to Ag 0 in an aqueous methanolic solution and using a solvent-free method (solid phase) under microwave irradiation. In the solid phase synthesis, the size and shape of the AgNPs can be controlled by varying the weight ratio of mPEGTH2 to AgNO 3 used. In addition, the antimicrobial activity depends on the ratio of mPEGTH2 to AgNO 3. The mPEGTH2-AgNPs (2:1) demonstrated higher antimicrobial activity compared to mPEGTH2-AgNPs (1:1) against Gram-positive bacteria, Gram-negative bacteria, and C.albicans. Results: This work presents simple methods for the synthesis of AgNPs using modified methoxypolyethylene glycol with bishydrazino-s-triazine (mPEGTH2); a solution method, using methanol-water medium at room temperature, and a solvent-free (solid phase) method, employing microwave irradiation or direct heating which could be used for the preparation of AgNPs on large scale. In the solid phase, ratios of mPEGTH2 to AgNO 3 (1:1 or 2:1, respectively) are very important to control the size and shape of AgNPs. While in solution phase is not necessary where the molar ratio used is 10:1. Most of the experimental methods resulted in AgNPs ranging in size from 7 to 10 nm as observed from XRD and TEM characterization. The antimicrobial activity of the AgNPs was also dependent on the weight ratio of mPEGTH2 to AgNO 3 , with a large effect as observed when using the solvent-free method. The mPEGTH2-AgNPs (2:1) demonstrated higher antimicrobial activities compared to mPEGTH2-AgNPs (1:1) against S. aureus, S. epidermidis, E. faecalis, E. coli, P. aeruginosa, S. typhimurium, and C. albicans. In all cases, the MICs and MBCs of mPEGTH2-AgNPs (1:1) were lower than those of mPEGTH2-AgNPs (2:1). Conclusion: In summary, mPEGTH2-AgNPs (2:1) is a promising candidate to kill pathogenic microbes. In particular, the method used for the preparation of AgNPs by using polyethylene glycol polymer modified with bishydrazino-s-triazine has the most potential and would be the most cost-effective method. This method of the synthesis of nanoparticles may be suitable for the preparation of other metal nanoparticles, which would allow for numerous applications in medicinal and industrial.

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“…170 This in situ production of free radicals by AgNPs is usually enhanced by exposure to light-sources of variable wavelengths, this feature is currently explored also for photocatalytic degradation of pigments. 171,172 The ROS generation within the activated cells is mediated by enhancement of: 1. cytoplasmic ROS (cytoROS) production by NADPH oxidase family of enzymes (e.g. endothelial, neuronal and inducible nitric oxide synthases)(eNOS, nNOS, iNOS) during inflammation; 2.…”

Section: Generation Of Reactive Oxygen Species (Ros)mentioning

confidence: 99%

Silver Nanoparticles for the Therapy of Tuberculosis

Tabaran

Matea²,

Mocan³

et al. 2020

IJN

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Rapid emergence of aggressive, multidrug-resistant Mycobacteria strain represents the main cause of the current antimycobacterial-drug crisis and status of tuberculosis (TB) as a major global health problem. The relatively low-output of newly approved antibiotics contributes to the current orientation of research towards alternative antibacterial molecules such as advanced materials. Nanotechnology and nanoparticle research offers several exciting new-concepts and strategies which may prove to be valuable tools in improving the TB therapy. A new paradigm in antituberculous therapy using silver nanoparticles has the potential to overcome the medical limitations imposed in TB treatment by the drug resistance which is commonly reported for most of the current organic antibiotics. There is no doubt that AgNPs are promising future therapeutics for the medication of mycobacterial-induced diseases but the viability of this complementary strategy depends on overcoming several critical therapeutic issues as, poor delivery, variable intramacrophagic antimycobacterial efficiency, and residual toxicity. In this paper, we provide an overview of the pathology of mycobacterial-induced diseases, andhighlight the advantages and limitations of silver nanoparticles (AgNPs) in TB treatment.

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Biosynthesized silver nanoparticles using Bacillus amyloliquefaciens; Application for cytotoxicity effect on A549 cell line and photocatalytic degradation of p-nitrophenol

Cited by 154 publications

References 60 publications

<p>The Antibacterial Mechanism of Silver Nanoparticles and Its Application in Dentistry</p>

<p>The Antibacterial Mechanism of Silver Nanoparticles and Its Application in Dentistry</p>

<p>Simple Approaches for the Synthesis of AgNPs in Solution and Solid Phase Using Modified Methoxypolyethylene Glycol and Evaluation of Their Antimicrobial Activity</p>

<p>Silver Nanoparticles for the Therapy of Tuberculosis</p>

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