Biosynthesis of Xylitol from Glucose: Microorganism, Key Enzymes and Genetically Engineered Strains

Qi, Yilin

doi:10.11648/j.bio.20170505.13

Cited by 2 publications

(1 citation statement)

References 22 publications

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“…JX-05. Co-biotransformation with both recombinant strains improved the xylitol yield by two times in comparison with wild Gluconobacter sp., possibly due to the utilization of other carbon sources along with xylose [51][52][53]. An endogenous aldose reductase gene GRE3 and a xylose transporter gene SUT1 gene were overexpressed in the industrial yeast strain of S. cerevisiae for xylitol production from agricultural biomass.…”

Section: Strain Improvementmentioning

confidence: 99%

Biological and Pharmacological Potential of Xylitol: A Molecular Insight of Unique Metabolism

Ahuja

Macho

Ewe

et al. 2020

Foods

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Xylitol is a white crystalline, amorphous sugar alcohol and low-calorie sweetener. Xylitol prevents demineralization of teeth and bones, otitis media infection, respiratory tract infections, inflammation and cancer progression. NADPH generated in xylitol metabolism aid in the treatment of glucose-6-phosphate deficiency-associated hemolytic anemia. Moreover, it has a negligible effect on blood glucose and plasma insulin levels due to its unique metabolism. Its diverse applications in pharmaceuticals, cosmetics, food and polymer industries fueled its market growth and made it one of the top 12 bio-products. Recently, xylitol has also been used as a drug carrier due to its high permeability and non-toxic nature. However, it become a challenge to fulfil the rapidly increasing market demand of xylitol. Xylitol is present in fruit and vegetables, but at very low concentrations, which is not adequate to satisfy the consumer demand. With the passage of time, other methods including chemical catalysis, microbial and enzymatic biotransformation, have also been developed for its large-scale production. Nevertheless, large scale production still suffers from high cost of production. In this review, we summarize some alternative approaches and recent advancements that significantly improve the yield and lower the cost of production.

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Section: Strain Improvementmentioning

confidence: 99%