Biosynthesis of Silver Nanoparticles With Antimicrobial and Anticancer Properties Using Two Novel Yeasts

Abstract

AgNPs is nanomaterials with many potential biomedical applications. In this study, two novel yeast strains named as HX-YS and LPP-12Y capable of producing biological silver nanoparticles were isolated. Based on sequencing of ribosomal DNA-ITS fragments, as well as partial D1/D2 regions of 26S rDNA be similar with genus Metschnikowia. The BioAgNPs produced by HX-YS and LPP-12Y at pH of 5.0 - 6.0 and 26℃ ranged in size from 50 to 500 nm. The antibacterial activities of yeast BioAgNPs against five pathogenic bacteria were determined. The highest antibacterial effect was observed on P. aeruginosa, with additional obvious effects on E. coli ATCC8099 and S. aureus ATCC10231. Additionally, the BioAgNPs showed antiproliferative effects on lung cancer cell lines H1975 and A579, with low toxicity in Beas 2B normal lung cells. Therefore, the AgNPs biosynthesized by HX-YS and LPP-12Y may have potential applications in the treatment of bacterial infections and cancer.

Enhanced Multimodal Effect of Chemotherapy, Hyperthermia and Magneto-Mechanic Actuation of Silver-Coated Magnetite on Cancer Cells

“…Consequently, silver nanoparticles are being intensively explored for various applications due to their specific physicochemical characteristics such as large surface-area-to-volume ratio, increased surface plasmon resonance, and ease of ligand functionalization [21]. Accordingly, they were tested for different biomedical applications due to their antibacterial, antiviral, antifungal, anti-inflammatory, anti-angiogenic, and antitumor effects [20,22]. Silver and silver nanoparticles have been recently shown to exert cytotoxic effects on cancer cells but not on normal cells, being proposed as a tumor theranostic agent [23].…”