Biosynthesis of Ribose and Deoxyribose in Escherichia coli

Oxygen-18 studies on the oxidative and nonoxidative pentose phosphate pathways in wild-type and mutant Escherichia coli cells

“…This method cannot detect the extent of contribution of the nonoxidative pathway. The conversion of 14C-labeled substrates to the pentose phosphate moieties of DNA and RNA has been used to estimate the relative contribution of both pathways (Bagatell et al, 1959;Sable and Cassisi, 1962;Wood et al, 1963). It was shown (Szynkiewicz et al, 1961;Model and Rittenberg, 1967) that the activities of the two pathways varied considerably with the conditions of growth of the organism.…”