Biosynthesis of Polyphenols in Recombinant Micro‐organisms

The beauty of biocatalysis: sustainable synthesis of ingredients in cosmetics

“…Since the first reports into the metabolic engineering of Saccharomyces cerevisiae and E. coli , 146–148 further research into resveratrol production in several hosts has been achieved, including: E. coli , Lactococcus lactis , Streptomyces venezuelae , and Corynebacterium glutamicum Saccharomyces cerevisiae . 132,134,149–156 Clustering of the metabolic enzymes by coiled coils (coiling of multiple α-helices) has also proved to be successful at improving the formation of resveratrol in E. coli . 157…”

“…Therefore, biological technologies, as discussed previously, are being used increasingly to obtain these compounds. 155,188 International trade and demand for flavonoids is expected to pass 1 trillion by 2020. 188 Currently the flavonoids used in cosmetics are extracted from plants using various techniques, however they are not without drawbacks, as such there has been increased interest in more improved methods for their extraction and purification.…”