Biosynthesis of Octacosamicin A: Uncommon Starter/extender Units and Product Releasing via Intermolecular Amidation
Yanghui Liao,
Xue‐Jiao Wang,
Guang‐Lei Ma
et al.
Abstract:Octacosamicin A is an antifungal metabolite featuring a linear polyene‐polyol chain flanked by N‐hydroxyguanidine and glycine moieties. We report here that sub‐inhibitory concentrations of streptomycin elicited the production of octacosamicin A in Amycolatopsis azurea DSM 43854T. We identified the biosynthetic gene cluster (oca BGC) that encodes a modular polyketide synthase (PKS) system for assembling the polyene‐polyol chain of octacosamicin A. Our analysis suggested that the N‐hydroxyguanidine unit originat… Show more
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