Biosynthesis of melatonin from l-tryptophan by an engineered microbial cell factory
Lijuan Wang,
Yongdong Deng,
Jianjie Gao
et al.
Abstract:Background
The demand for melatonin is increasing due to its health-promoting bioactivities such as antioxidant and sleep benefits. Although melatonin is present in various organisms, its low content and high extraction cost make it unsustainable. Biosynthesis is a promising alternative method for melatonin production. However, the ectopic production of melatonin in microorganisms is very difficult due to the low or insoluble expression of melatonin synthesis genes. Hence, we aim to explore the… Show more
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