Biosynthesis of griseofulvin: the methylated benzophenone intermediates

Abstract

for preparation of lignified coleoptiles and the suggestion that larger quantities of eugenol lignin could be produced on potato parenchyma. He is grateful to Mrs M. Szilagyi for technical assistance. The microanalyses were carried out by the Australian Microanalytical Service.

Bromomonamycins, Unnatural Analogues of the Monamycin Cyclodepsipeptide Antibiotics: Production, Isolation, and Biological Activity

“…However, formation of the latter could not be induced by using P. patulum (7), illustrating that such manipulations were strain or species dependent.…”

The Relationship of a Phenolic Metabolite and a Morphological Character of Aspergillus rugulosus

“…overnight, discarding the aqueous layer and adding acetic acid (0.5% by vol.) to the upper layer (Rhodes, Boothroyd, McGonagle & Somerfield, 1961). System (XI) was modified from Coulson & Evans (1958) and was composed of benzene + acetic acid + water (20 + 5 + 4, by vol.).…”

The Chemistry of Griseofulvin

“…Similarly, deletion of the methyltransferase GsfC clarified that the second methylation takes place at 2' before formation of the grisan ring in agreement with previous feeding studies. 82 Deletion of the third methyltransferase encoding gene GsfD showed that C-7 chlorination takes place before methylation of O-4 since desmethyl-dehydrogriseofulvin (13) accumulated. C-7 chlorination was also demonstrated to take place prior to grisan ring formation since griseophenone B (12) accumulated in the GsfF knockout strain.…”