Biosynthesis of gold nanoparticles using Nigella sativa and Curtobacterium proimmune K3 and evaluation of their anticancer activity

Dhandapani, Sanjeevram; Xu, Xingyue; Wang, Rongbo; Puja, Aditi Mitra; Kim, Hoon; Perumalsamy, Haribalan; Balusamy, Sri Renukadevi; Kim, Yeon-Ju

doi:10.1016/j.msec.2021.112214

Cited by 23 publications

(16 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This is also consistent with the result of EDX spectroscopy ( Figure 5F ), in which only gold element peaks were observed in the synthesized EJ-AuNPs, suggesting that EJ-AuNPs were successfully synthesized without impurities. Excepting the Au peaks, other peaks without symbol observed at 1.9, 8.0, and 8.9 keV were confirmed as copper grids which is used as sample support on the EDX spectrum ( Dhandapani et al, 2021 ).…”

Section: Resultsmentioning

confidence: 97%

See 1 more Smart Citation

Structural properties and anti-dermatitis effects of flavonoids-loaded gold nanoparticles prepared by Eupatorium japonicum

Moon²,

Kim³

et al. 2022

Front. Pharmacol.

Self Cite

View full text Add to dashboard Cite

Recently, green synthesis-based nanoformulations using plants or microorganisms have attracted great interest because of their several advantages. Nanotechnology-based biological macromolecules are emerging materials with potential applications in cosmetics and medications for ameliorating and treating inflammatory skin diseases (ISDs). Eupatorium japonicum (EJ), a native Korean medicinal plant belonging to the family Asteraceae, has been traditionally used to prepare prescriptions for the treatment of various inflammatory diseases. EJ-based gold nanoparticles (EJ-AuNPs) were biosynthesized under optimal conditions and characterized their physicochemical properties using various microscopic and spectrometric techniques. Additionally, the effects of EJ-AuNPs on ISDs as well as their underlying mechanisms were investigated in the tumor necrosis factor-α/interferon-γ (T+I)-induced skin HaCaT keratinocytes. The MTT and live/dead cell staining assays showed that EJ-AuNP treatment was considerably safer than EJ treatment alone in HaCaT cells. Moreover, EJ-AuNP treatment effectively suppressed the production of T+I-stimulated inflammatory cytokines (RANTES, TARC, CTACK, IL-6, and IL-8) and intracellular reactive oxygen species, and such EJ-driven anti-inflammatory effects were shown to be associated with the downregulation of intracellular mitogen-activated protein kinase and nuclear factor-κB signaling pathways. The present study provides preliminary results and a valuable strategy for developing novel anti-skin dermatitis drug candidates using plant extract-based gold nanoparticles.

show abstract

Section: Resultsmentioning

confidence: 97%

“…Excepting the Au peaks, other peaks without symbol observed at 1.9, 8.0, and 8.9 keV were confirmed as copper grids which is used as sample support on the EDX spectrum (Dhandapani et al, 2021).…”

Section: Characterization Of the Physiochemical Properties Of Ej-aunpsmentioning

confidence: 89%

Structural properties and anti-dermatitis effects of flavonoids-loaded gold nanoparticles prepared by Eupatorium japonicum

Moon²,

Kim³

et al. 2022

Front. Pharmacol.

Self Cite

View full text Add to dashboard Cite

show abstract

“…The biosynthesized RR-AuNPs were prepared from RRE as described previously . In addition, four reaction parameters were examined to optimize the biosynthesis of the RR-AuNP, including the RRE and tetrachloroauric(III) acid trihydrate (gold salts; Sigma-Aldrich, St. Louis, MO, USA) concentrations, reaction temperature, and reaction time .…”

Section: Methodsmentioning

confidence: 99%

“… 48 In addition, four reaction parameters were examined to optimize the biosynthesis of the RR-AuNP, including the RRE and tetrachloroauric(III) acid trihydrate (gold salts; Sigma-Aldrich, St. Louis, MO, USA) concentrations, reaction temperature, and reaction time. 48 After the reaction of RRE and the gold salts, the color change was evaluated and absorbance at 300–800 nm was determined visually and using a UV–vis spectrophotometer (Agilent Technologies, Santa Clara, CA, USA), respectively. The synthesized RR-AuNPs were centrifuged at 13,475 g for 10 min and washed five times with deionized water along with repeated centrifugation.…”

Section: Methodsmentioning

confidence: 99%

Biologically Synthesized Rosa rugosa-Based Gold Nanoparticles Suppress Skin Inflammatory Responses via MAPK and NF-κB Signaling Pathway in TNF-α/IFN-γ-Induced HaCaT Keratinocytes

et al. 2022

Self Cite

View full text Add to dashboard Cite

Nanotechnology-applied materials and related therapeutics have gained attention for treating inflammatory skin diseases. The beach rose (Rosa rugosa), belonging to the family Rosaceae, is a perennial, deciduous woody shrub endemic to northeastern Asia. In this study, R. rugosa-based gold nanoparticles (RR-AuNPs) were biologically synthesized under optimal conditions to explore their potential as anti-inflammatory agents for treating skin inflammation. The synthesized RR-AuNPs were analyzed using field emission-transmission electron microscopy, energy-dispersive X-ray spectrometry, selected-area electron diffraction, and X-ray diffraction. The uniformly well-structured AuNPs showed near-spherical and polygonal shapes. Cell viability evaluation and optical observation results showed that the RR-AuNPs were absorbed by human keratinocytes without causing cytotoxic effects. The effects of RR-AuNPs on the skin inflammatory response were investigated in human keratinocytes treated with tumor necrosis factor-α/interferon-γ (T + I). The results showed that T + I-stimulated increases in inflammatory mediators, including chemokines, interleukins, and reactive oxygen species, were significantly suppressed by RR-AuNP treatment in a concentration-dependent manner. The western blotting results indicated that the RR-AuNP-mediated anti-inflammatory effects were highly associated with the suppression of inflammatory signaling, mitogen-activated protein kinase, and nuclear factor-κB. These results demonstrate that plant extract-based AuNPs are novel anti-inflammatory candidates for topical application to treat skin inflammation.

show abstract

“…In addition, they are preferably less toxic and easy to synthesize in less time compared to other metallic NPs [107]. In a recent study, gold NPs were prepared using Nigella sativa (black cumin) seed extract and membrane vesicles of a Curtobacterium proimmune K3 (probiotic) [89]. The resulting NPs were in the size range of 30-50 nm as per TEM photomicrographs with an elliptical or polygonal shape.…”

Section: Metallic Nanoparticlesmentioning

confidence: 99%

Novel Drug Delivery Systems as an Emerging Platform for Stomach Cancer Therapy

et al. 2022

View full text Add to dashboard Cite

Cancer has long been regarded as one of the world’s most fatal diseases, claiming the lives of countless individuals each year. Stomach cancer is a prevalent cancer that has recently reached a high number of fatalities. It continues to be one of the most fatal cancer forms, requiring immediate attention due to its low overall survival rate. Early detection and appropriate therapy are, perhaps, of the most difficult challenges in the fight against stomach cancer. We focused on positive tactics for stomach cancer therapy in this paper, and we went over the most current advancements and progressions of nanotechnology-based systems in modern drug delivery and therapies in great detail. Recent therapeutic tactics used in nanotechnology-based delivery of drugs aim to improve cellular absorption, pharmacokinetics, and anticancer drug efficacy, allowing for more precise targeting of specific agents for effective stomach cancer treatment. The current review also provides information on ongoing research aimed at improving the curative effectiveness of existing anti-stomach cancer medicines. All these crucial matters discussed under one overarching title will be extremely useful to readers who are working on developing multi-functional nano-constructs for improved diagnosis and treatment of stomach cancer.

show abstract

Biosynthesis of gold nanoparticles using Nigella sativa and Curtobacterium proimmune K3 and evaluation of their anticancer activity

Cited by 23 publications

References 47 publications

Structural properties and anti-dermatitis effects of flavonoids-loaded gold nanoparticles prepared by Eupatorium japonicum

Structural properties and anti-dermatitis effects of flavonoids-loaded gold nanoparticles prepared by Eupatorium japonicum

Biologically Synthesized Rosa rugosa-Based Gold Nanoparticles Suppress Skin Inflammatory Responses via MAPK and NF-κB Signaling Pathway in TNF-α/IFN-γ-Induced HaCaT Keratinocytes

Novel Drug Delivery Systems as an Emerging Platform for Stomach Cancer Therapy

Contact Info

Product

Resources

About