Biosynthesis of aflatoxins.

Maggon, K. K.; Gupta, S. K.; Venkitasubramanian, T. A.

doi:10.1128/mmbr.41.4.822-855.1977

Cited by 83 publications

(45 citation statements)

References 149 publications

(290 reference statements)

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“…An exception to the "breakpoint" noted above was the apparent low level aflatoxin synthesis (based on X/Xo > 2.0) in conjunction with malate a n d aspartate. Generally, amino acids a n d tricarboxylic acid cycle intermediates as sole carbon sources are not considered to support aflatoxin synthesis (Davis a n d Diener 1968; Maggon et al 1977;…”

Section: Discussionmentioning

confidence: 99%

ABILITY OF VARIOUS CARBON SOURCES TO INDUCE AND SUPPORT AFLATOXIN SYNTHESIS BY ASPERGILLUS PARASITICUS

Buchanan

Stahl

1984

Journal of Food Safety

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The ability of a wide variety of carbon sources to induce and support aflatoxin synthesis by Aspergillus parasiticus was examined using mycelia pregrown in a peptone‐mineral salts medium that does not support aflatoxin synthesis. Sugars and derivatives of sugars supported widely varying amounts of aflatoxin production. Amino acids and tricarboxylic acid cycle intermediates except aspartate and malate, respectively, did not appear to support de novo aflatoxin synthesis. Embden‐Meyerhoff pathway intermediates prior to, but not after, 3‐phosphoglycerate supported aflatoxin synthesis.

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Section: Discussionmentioning

confidence: 99%

ABILITY OF VARIOUS CARBON SOURCES TO INDUCE AND SUPPORT AFLATOXIN SYNTHESIS BY ASPERGILLUS PARASITICUS

Buchanan

Stahl

1984

Journal of Food Safety

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“…High levels of pyruvate have indeed been shown in SLS cultures during transitional growth phase (Rao 1979). Maggon et at. (1977) have proposed that a high level of pyruvate during the transitional growth phase is necessary for the continued aflatoxin biosynthesis.…”

Section: Discussionmentioning

confidence: 99%

Nitrogen metabolism in Aspergillus parasiticus NRRL 3240 and A. flavus NRRL 3537 in relation to aflatoxin production

Bhatnagar

Ahmad

Mukerji

et al. 1986

Journal of Applied Bacteriology

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The relationship between nitrogen assimilation, metabolism and aflatoxin formation has been investigated in a toxigenic and a non-toxigenic strain of Aspergillus parasiticus. Ammonia from the medium is mainly assimilated via NADP-requiring glutamate dehydrogenase. During growth NAD-requiring glutamate dehydrogenase followed an inverse pattern of activity with respect to NADP glutamate dehydrogenase. Alpha-ketoglutarate, the product of NAD glutamate dehydrogenase, stimulated acetate incorporation into aflatoxins. Glutamine synthetase, ornithine transcarbamylase, both utilizing glutamate as substrate were assayed under different growth conditions. An important regulatory role for glutamine synthetase is suggested. The metabolic route of asparagine utilization was also investigated. Both the known pathways, glutamate oxaloacetate transaminase and glutamate pyruvate transaminase are operative simultaneously.

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“…The composition of the growth medium can affect the aflatoxin production of A.parasiticus (Maggon et al 1977). High levels of certain carbohydrates including sucrose and glucose, stimulate aflatoxin production (Davis and Diener 1968).…”

Section: The Effect Of the Growth Medium On Asexual Development And Amentioning

confidence: 99%

“…(Bojovic-Cvetic and Vujicic 1974). A. parasiticus is not well understood as a developmental system but has been characterized with respect to its ability to produce aflatoxin, a potent hepatocarcinogen (Maggon et al 1977).…”

Section: Introductionmentioning

confidence: 99%

RELATIONSHIP OF ASEXUAL DEVELOPMENT TO AFLATOXIN PRODUCTION IN ASPERGILLUS PARASITICUS

Batt

1983

Journal of Food Safety

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The association between asexual development and aflatoxin production in Aspergillus parasiticus is reviewed. Aflatoxin does not appear to be a product of asexual development. The ability to sporulate and to produce aflatoxin are not mutually exclusive of each other. The environment regulates the asexual development and aflatoxin production. The initial inoculum level will affect the competence time and the time of initiation of aflatoxin production. The time of initiation of aflatoxin production is independent of the initial composition of the medium, in contrast to the onset of sporulation which is dependent on the medium.

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Biosynthesis of aflatoxins.

Cited by 83 publications

References 149 publications

ABILITY OF VARIOUS CARBON SOURCES TO INDUCE AND SUPPORT AFLATOXIN SYNTHESIS BY ASPERGILLUS PARASITICUS

ABILITY OF VARIOUS CARBON SOURCES TO INDUCE AND SUPPORT AFLATOXIN SYNTHESIS BY ASPERGILLUS PARASITICUS

Nitrogen metabolism in Aspergillus parasiticus NRRL 3240 and A. flavus NRRL 3537 in relation to aflatoxin production

RELATIONSHIP OF ASEXUAL DEVELOPMENT TO AFLATOXIN PRODUCTION IN ASPERGILLUS PARASITICUS

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