Biosynthesis, characterization, biological and photo catalytic investigations of Elsholtzia blanda and chitosan mediated copper oxide nanoparticles

Maheo, Athisa Roselyn; Vithiya, B. Scholastica Mary; Prasad, T. Augustine Arul; Tamizhdurai, P.; Mangesh, V.L.

doi:10.1016/j.arabjc.2021.103661

Cited by 17 publications

(8 citation statements)

References 60 publications

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“…The green-synthesized nanoparticles of CH, CuO, and CH-CuO were characterized by different techniques, where the SEM and TEM analyses showed roughly spherical-shaped nanoparticles with average sizes of 62 nm, 35 nm, and 51 nm, respectively. The calculated particle sizes for the nanoparticles were found to be within the range reported by the previous studies ( Ali et al, 2011 ; Maheo et al, 2022 ).…”

Section: Discussionsupporting

confidence: 84%

Comparative analysis of phyto-fabricated chitosan, copper oxide, and chitosan-based CuO nanoparticles: antibacterial potential against Acinetobacter baumannii isolates and anticancer activity against HepG2 cell lines

et al. 2023

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The aim of this study was to provide a comparative analysis of chitosan (CH), copper oxide (CuO), and chitosan-based copper oxide (CH-CuO) nanoparticles for their application in the healthcare sector. The nanoparticles were synthesized by a green approach using the extract of Trianthema portulacastrum. The synthesized nanoparticles were characterized using different techniques, such as the synthesis of the particles, which was confirmed by UV–visible spectrometry that showed absorbance at 300 nm, 255 nm, and 275 nm for the CH, CuO, and CH-CuO nanoparticles, respectively. The spherical morphology of the nanoparticles and the presence of active functional groups was validated by SEM, TEM, and FTIR analysis. The crystalline nature of the particles was verified by XRD spectrum, and the average crystallite sizes of 33.54 nm, 20.13 nm, and 24.14 nm were obtained, respectively. The characterized nanoparticles were evaluated for their in vitro antibacterial and antibiofilm potential against Acinetobacter baumannii isolates, where potent activities were exhibited by the nanoparticles. The bioassay for antioxidant activity also confirmed DPPH scavenging activity for all the nanoparticles. This study also evaluated anticancer activities of the CH, CuO, and CH-CuO nanoparticles against HepG2 cell lines, where maximum inhibitions of 54, 75, and 84% were recorded, respectively. The anticancer activity was also confirmed by phase contrast microscopy, where the treated cells exhibited deformed morphologies. This study demonstrates the potential of the CH-CuO nanoparticle as an effective antibacterial agent, having with its antibiofilm activity, and in cancer treatment.

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Section: Discussionsupporting

confidence: 84%

Comparative analysis of phyto-fabricated chitosan, copper oxide, and chitosan-based CuO nanoparticles: antibacterial potential against Acinetobacter baumannii isolates and anticancer activity against HepG2 cell lines

et al. 2023

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“…The interface between the copper source released the nitrate compounds and reduced the copper valency. The phenolic compounds of mulberry extract increased the growth of the Cu 2+ phase and their flavonoids stabilized the oxygen [26][27][28][29][30]. The enriched electrons from the plant derivatives produced the chemical unrestricted reduction and their hydroxyl compounds formed the precipitations.…”

Section: Cuo Nanoparticles Growth Mechanismmentioning

confidence: 99%

Green method for synthesis and characterization of copper oxide nanoparticles using Mulberry plant extract and their antibacterial, antioxidant and photocatalytic activity

Shkir¹

2022

Phys. Scr.

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The green synthesis of metal oxide nanoparticles is treated to be an eco-friendly path and cost-effectiveness. Mulberry plant extract was used to synthesize CuO nanoparticles in this study. UV spectroscopy absorbance at 370 nm was used to analyze the resulting synthesized nanoparticles. The distribution of nanoparticles and particle sizes were discovered to be in the range of 40-60 nm using scanning electron microscopy. Copper nanoparticles have characteristic diffraction peaks in the X-ray diffraction spectrum at 38.81°, and 66.35° which correspond to lattice planes (111) and (202), respectively. The antioxidant and antibacterial activity of the CuO nanoparticles was tested against gram-positive and gram-negative microorganisms. The results support the hypothesis that green synthesized CuO NPs could be a viable treatment option for diseases caused by microbial pathogens. This fact-finding result is that Mulberry plant extract-based green synthesized CuO nanoparticles destroyed or considerably inhibited pathogen activity, as well as having high antioxidant activity.

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“…An excess of ROS leads to oxidative stress that results in cellular damage or abnormal cell growth. Anti-oxidizing agents help in scavenging these free radicals from the bodily cells and in preventing the damage caused by their chain reactions [ 43 ]. DPPH is a well-known toxic free radical that can pose detrimental effects on human health.…”

Section: Resultsmentioning

confidence: 99%

Synthesis of Magnetic Iron Oxide-Incorporated Cellulose Composite Particles: An Investigation on Antioxidant Properties and Drug Delivery Applications

et al. 2023

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In recent years, polymer-supported magnetic iron oxide nanoparticles (MIO-NPs) have gained a lot of attention in biomedical and healthcare applications due to their unique magnetic properties, low toxicity, cost-effectiveness, biocompatibility, and biodegradability. In this study, waste tissue papers (WTP) and sugarcane bagasse (SCB) were utilized to prepare magnetic iron oxide (MIO)-incorporated WTP/MIO and SCB/MIO nanocomposite particles (NCPs) based on in situ co-precipitation methods, and they were characterized using advanced spectroscopic techniques. In addition, their anti-oxidant and drug-delivery properties were investigated. Field emission scanning electron microscopy (FESEM) and X-ray diffraction (XRD) analyses revealed that the shapes of the MIO-NPs, SCB/MIO-NCPs, and WTP/MIO-NCPs were agglomerated and irregularly spherical with a crystallite size of 12.38 nm, 10.85 nm, and 11.47 nm, respectively. Vibrational sample magnetometry (VSM) analysis showed that both the NPs and the NCPs were paramagnetic. The free radical scavenging assay ascertained that the WTP/MIO-NCPs, SCB/MIO-NCPs, and MIO-NPs exhibited almost negligible antioxidant activity in comparison to ascorbic acid. The swelling capacities of the SCB/MIO-NCPs and WTP/MIO-NCPs were 155.0% and 159.5%, respectively, which were much higher than the swelling efficiencies of cellulose-SCB (58.3%) and cellulose-WTP (61.6%). The order of metronidazole drug loading after 3 days was: cellulose-SCB < cellulose-WTP < MIO-NPs < SCB/MIO-NCPs < WTP/MIO-NCPs, whereas the sequence of the drug-releasing rate after 240 min was: WTP/MIO-NCPs < SCB/MIO-NCPs < MIO-NPs < cellulose-WTP < cellulose-SCB. Overall, the results of this study showed that the incorporation of MIO-NPs in the cellulose matrix increased the swelling capacity, drug-loading capacity, and drug-releasing time. Therefore, cellulose/MIO-NCPs obtained from waste materials such as SCB and WTP can be used as a potential vehicle for medical applications, especially in a metronidazole drug delivery system.

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Biosynthesis, characterization, biological and photo catalytic investigations of Elsholtzia blanda and chitosan mediated copper oxide nanoparticles

Cited by 17 publications

References 60 publications

Comparative analysis of phyto-fabricated chitosan, copper oxide, and chitosan-based CuO nanoparticles: antibacterial potential against Acinetobacter baumannii isolates and anticancer activity against HepG2 cell lines

Comparative analysis of phyto-fabricated chitosan, copper oxide, and chitosan-based CuO nanoparticles: antibacterial potential against Acinetobacter baumannii isolates and anticancer activity against HepG2 cell lines

Green method for synthesis and characterization of copper oxide nanoparticles using Mulberry plant extract and their antibacterial, antioxidant and photocatalytic activity

Synthesis of Magnetic Iron Oxide-Incorporated Cellulose Composite Particles: An Investigation on Antioxidant Properties and Drug Delivery Applications

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