Biosynthesis and Production of Tetrocarcin A, a New Antitumor Antibiotic in Chemically Defined Medium

Tamaoki, Tatsuya; Tomita, Fusao

doi:10.1080/00021369.1982.10865192

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Biosynthesis Of Spirotetronates1

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“…The biosynthetic pathways of the class II polyketide spirotetronates have been elucidated for chlorothricin, 21 tetrocarcin A, 22 kijanimicin, 23 and versipelostatin. 24 Following chain elongation, the diene and dienophile groups of 20 undergo an IMDA to construct the characteristic decalin moiety of 21 .…”

Section: Biosynthesis Of Spirotetronatesmentioning

confidence: 99%

Spirotetronate Polyketides as Leads in Drug Discovery

Lacoske

Theodorakis

2014

J. Nat. Prod.

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The discovery of chlorothricin (1) defined a new family of microbial metabolites with potent antitumor antibiotic properties collectively referred to as spirotetronate polyketides. These microbial metabolites are structurally distinguished by the presence of a spirotetronate motif embedded within a macrocyclic core. Glycosylation at the periphery of this core contributes to the structural complexity and bioactivity of this motif. The spirotetronate family displays impressive chemical structures, potent bioactivities, and significant pharmacological potential. This review groups the family members based on structural and biosynthetic considerations and summarizes synthetic and biological studies that aim to elucidate their mode of action and explore their pharmacological potential.

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