Biosynthesis and metabolism of steroids in molluscs

Fernandes, Denise; Loi, Barbara; Porte, Cinta

doi:10.1016/j.jsbmb.2010.12.009

Cited by 83 publications

(47 citation statements)

References 57 publications

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“…So, EROD is not only correlated to the activity of CYP4 in molluscs. Cytochromes p450 are involved in the metabolism of steroids in molluscs (Fernandes et al 2011). …”

Section: Discussionmentioning

confidence: 99%

Responses of cytochrome P450, GST, and MXR in the mollusk Corbicula fluminea to the exposure to hospital wastewater effluents

Bonnafé

Sroda

Budzinski

et al. 2015

Environ Sci Pollut Res

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Pharmaceutical products are a major group of chemical compounds that are continuously released into the environment. The primary pathway of pharmaceuticals to the aquatic environment is the discharge of wastewater effluents. The Psychiatric hospital of Montpon (Dordogne, France) operates with its wastewater treatment plant. We first evaluated the presence and concentrations of 27 pharmaceuticals compounds in these effluents. All of the 27 compounds were detected in these wastewater effluents at concentrations ranging between 37,500 ng L(-1) (paracetamol) and 150 ng L(-1) (citalopram). The aim of the study was then to evaluate the exposure effects of the effluents on cytochrome P450, GST, and MXR responses in Corbicula fluminea gills and digestive glands. Experiments on clams exposed during 1, 3, 7 14, and 21 days revealed a strong and continuous overexpression of mdr1 (multidrug resistant 1) gene expression in gills and transitory variations in pi-gst expression and GST activity. EROD activity increased also transitory after 1 day in the digestive gland of exposed clams. These results indicated that in the effluent, some molecules have undergone metabolism of phase 1 and/or phase 2.

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“…So, EROD is not only correlated to the activity of CYP4 in molluscs. Cytochromes p450 are involved in the metabolism of steroids in molluscs (Fernandes et al 2011). …”

Section: Discussionmentioning

confidence: 99%

Responses of cytochrome P450, GST, and MXR in the mollusk Corbicula fluminea to the exposure to hospital wastewater effluents

Bonnafé

Sroda

Budzinski

et al. 2015

Environ Sci Pollut Res

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“…Since PRG, estradiol and testosterone as functional hormones in mollusc are the same as those of vertebrates, and vertebrates continuously excrete them not just via urine and faces, but via their body surface or gills (in fish), the other possibility is that observed "molluscan" steroids just come from contamination [95,106]. At the same time, several papers have been published presenting evidence of steroidogenic activity and steroid metabolism in molluscs [107,108]. For example, beside other metabolic enzymes (e.g.…”

Section: Endocrine Steroid System Of Molluscs: Evidences and Questionsmentioning

confidence: 99%

“…Sepia officinalis and O. vulgaris) so far. These observations comprise a series of indications about the existence of steroidogenesis in different molluscs [107,108]. At present, no data are available about the expression of key enzymes in L. stagnalis, however the cholesterol which is the direct precursor of P5 has been described in its neurons [109].…”

Section: Marisa Cornuarietis Ilyanassa Obsolete Hexaplex Trunculusmentioning

confidence: 99%

Pond Snail Reproduction as Model in the Environmental Risk Assessment: Reality and Doubts

Pirger¹,

Zrínyi²,

Maász³

et al. 2018

Biological Resources of Water

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In European limnetic systems, the most relevant endocrine-disrupting chemicals (EDCs) of steroid type are the natural and synthetic hormones, phytosterols, pesticides, biocides and other chemicals produced by the plastic industry. Their presence in aquatic ecosystems represents a potentially adverse environmental and public health impact. Furthermore, this is a warning signal that the current handling of pharmaceuticals needs to be further improved. Nowadays, it has become clear that EDCs have specific disturbing effects on the neuroendocrine system of invertebrate and vertebrate aquatic animals, particularly gastropods. Among a latter, pond snail (Lymnaea stagnalis) has been used as the first aquatic non-arthropod test organism in studying the effect of EDCs because they are sensitive to various anthropogenic steroids, like progestogens. Investigating a variety of reproductive endpoints of Lymnaea, such as fecundity, oocyte production, egg mass production, the quality of egg masses, the shell size in development and after egg-laying, the time window of cell division in the offspring, the metabolite content of single-cell zygotes and egg albumen has concluded that progestogen contaminations in water are detrimental for reproduction and early stage development of Lymnaea. This chapter is an attempt to show whether Lymnaea reproduction, despite many altering reproductive endpoints, is a suitable model for environmental risk assessment or not.

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“…The presence of vertebrate-type sex steroids (e.g., progesterone (P4), androstenedione (AD), testosterone (T), and estradiol (E2)) together with some enzymes involved in sex steroid biosynthesis (e.g., 3␤/17␤-hydroxysteroid dehydrogenases -3␤/17␤-HSD -, 5␣-reductase) have been described in molluscs (Janer and Porte, 2007;Lafont and Mathieu, 2007;Fernandes et al, 2011). However, studies are still needed to better understand the role of steroids in mollusc's reproduction, to establish their origin (endogenous vs. exogenous) and their mechanisms of action (Scott, 2012(Scott, , 2013.…”

Section: Introductionmentioning

confidence: 99%

“…Apart from steroids, steroidogenic enzymes such are 5␣-reductases and 3␤/17␤-hydroxysteroid dehydrogenases (3␤/17␤-HSD) have been described in molluscs (Fernandes et al, 2011). The androgen precursor androstenedione (AD) is mainly metabolized to 5␣-reduced metabolites (5␣-dihydroandrostenedione (5␣-DHA) and 5␣-dihydrotestosterone (5␣-DHT)) and minor amounts of T in Mytilus galloprovincialis (Janer et al, 2005;Fernandes et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Progesterone is actively metabolized to 5α-pregnane-3,20-dione and 3β-hydroxy-5α-pregnan-20-one by the marine mussel Mytilus galloprovincialis

et al. 2015

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Biosynthesis and metabolism of steroids in molluscs

Cited by 83 publications

References 57 publications

Responses of cytochrome P450, GST, and MXR in the mollusk Corbicula fluminea to the exposure to hospital wastewater effluents

Responses of cytochrome P450, GST, and MXR in the mollusk Corbicula fluminea to the exposure to hospital wastewater effluents

Pond Snail Reproduction as Model in the Environmental Risk Assessment: Reality and Doubts

Progesterone is actively metabolized to 5α-pregnane-3,20-dione and 3β-hydroxy-5α-pregnan-20-one by the marine mussel Mytilus galloprovincialis

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