Biosynthesis and In-vitro Study of Gold Nanoparticles Using Mentha and Pelargonium Extracts

Jafarizad, Abbas; Safaee, Khadijeh; Gharibian, Soorena; Omidi, Yadollah; Ekinci, Duygu

doi:10.1016/j.mspro.2015.11.113

Cited by 48 publications

(19 citation statements)

References 23 publications

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“…Furthermore, a minor centered peak at 1402.15 cm -1 could be related to the existence of carboxylic components [15]. The centered peak at 1635.52 cm -1 , was attributed to the amide І group, which was related to the proteins and has key role in the stabilizing of formed Se NPs [10,15,24]. The mean pH value of ALE was about 5, indicating that the ALE is an acidic solution.…”

Section: Ale Specificationsmentioning

confidence: 97%

Aloe vera leaf extract mediated green synthesis of selenium nanoparticles and assessment of their In vitro antimicrobial activity against spoilage fungi and pathogenic bacteria strains

Fardsadegh

Jafarizadeh‐Malmiri

2019

Green Processing and Synthesis

161

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Selenium as an essential trace element for the health of the humans was used to hydrothermally synthesis of selenium nanoparticle (Se NPs) using Aloe vera leaf extract (ALE). Effects of synthesis parameters namely; amount of ALE (1–5 ml) and amount of Na2SeO3 solution (10–30 ml), on the particle size and colour intensity of the solution containing Se NPs were studied using response surface methodology. FT-IR spectroscopy, UV-Vis spectrophotometry, DLS analyzer and TEM were used to determine the specifications of the ALE and synthesized Se NPs. Obtained results indicated that the ALE contained several bioactive compounds, which they had hydroxyl and amide І groups in their structures and these two functional groups had key roles in the reduction of the selenium ions to form Se NPs and stabilizing of them. Furthermore, spherical fabricated Se NPs using obtained optimum synthesis parameters, 4.92 mL of ALE and 13.03 mL of Na2SeO3 solution, had colour intensity, mean particle size, zeta potential and polydispersity index values of 3.0% a.u., 50 nm, -18 mV and 0.344, respectively according to the DLS analysis. The synthesized Se NPs had also high antibacterial and antifungal activities against 4 selected pathogenic bacteria and spoilage fungi strains.

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Section: Ale Specificationsmentioning

confidence: 97%

Aloe vera leaf extract mediated green synthesis of selenium nanoparticles and assessment of their In vitro antimicrobial activity against spoilage fungi and pathogenic bacteria strains

Fardsadegh

Jafarizadeh‐Malmiri

2019

Green Processing and Synthesis

161

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“…The conventional physical and chemical methods used for AuNP synthesis involve the use of toxic chemicals, high energy processes and are expensive [ 9 , 10 , 11 ]. Studies have highlighted concerns regarding chemically synthesized NPs for biomedical applications due to the use of toxic reducing agents such as sodium citrate, sodium borohydride and byproducts formed during the synthesis process [ 11 , 12 ]. These chemicals are not only corrosive but also generate flammable by products during chemical synthesis.…”

Section: Introductionmentioning

confidence: 99%

“…Scientists have turned to green nanotechnology to produce metallic NPs using biological systems (e.g., microbes and plant extracts) [ 11 , 12 , 13 ]. Since biologicals are used in the synthesis process, the expectation is that the nanomaterials will be more biofriendly and the synthesis processes would be more environmentally friendly.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of Biogenic Gold Nanoparticles from Terminalia mantaly Extracts and the Evaluation of Their In Vitro Cytotoxic Effects in Cancer Cells

et al. 2020

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Scientists have demonstrated the potential of plant materials as ‘green’ reducing and stabilizing agents for the synthesis of gold nanoparticles (AuNPs) and opened new ecofriendly horizons to develop effective and less harmful treatment strategies. The current study demonstrated the use of Terminalia mantaly (TM) extracts to synthesize AuNPs with enhanced cytotoxic effects. The TM-AuNPs were synthesized at 25 and 70 °C using water (WTM) and methanolic (MTM) extracts of the leaf, root and stem/bark parts of the plant. The TM-AuNPs were characterized using UV–visible spectrophotometry, dynamic light scattering (DLS), transmission electron microscopy, energy dispersive X-ray (EDX), selection area electron diffraction (SAED) and Fourier transform infrared (FTIR) spectroscopy. Majority of the TM-AuNPs were spherical with a mean diameter between 22.5 and 43 nm and were also crystalline in nature. The cytotoxic effects of TM-AuNPs were investigated in cancer (Caco-2, MCF-7 and HepG2) and non-cancer (KMST-6) cell lines using the MTT assay. While the plant extracts showed some cytotoxicity towards the cancer cells, some of the TM-AuNPs were even more toxic to the cells. The IC50 values (concentrations of the AuNPs that inhibited 50% cell growth) as low as 0.18 µg/mL were found for TM-AuNPs synthesized using the root extract of the plant. Moreover, some of the TM-AuNPs demonstrated selective toxicity towards specific cancer cell types. The study demonstrates the potential of TM extracts to produce AuNPs and describe the optimal conditions for AuNPs using TM extracts. The toxicity of some the TM-AuNPs can possibly be explored in the future as an antitumor treatment.

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“…Au NPs from Magnolia kobus extract, analysed by FTIR, show peaks related to metabolites and proteins that were adsorbed on NPs surface. Jafarizad et al [65] used Mentha and Pelargonium plant extracts to achieve Au NPs (10-100 nm) with different shapes (triangular and polygonal NPs from Mentha and spherical for Pelargonium). First, the authors conducted GC-MS analysis of extracts, finding Isoeugenol and Spathulenol in Mentha extract whereas phenolic acids, tannins and flavonoids in Pelargonium: these molecules represented the reducing agents because of their OH functional groups.…”

Section: Au Npsmentioning

confidence: 99%

Green Plasmonic Nanoparticles and Bio-Inspired Stimuli-Responsive Vesicles in Cancer Therapy Application

et al. 2020

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In the last years, there is a growing interest in the application of nanoscaled materials in cancer therapy because of their unique physico-chemical properties. However, the dark side of their usability is limited by their possible toxic behaviour and accumulation in living organisms. Starting from this assumption, the search for a green alternative to produce nanoparticles (NPs) or the discovery of green molecules, is a challenge in order to obtain safe materials. In particular, gold (Au NPs) and silver (Ag NPs) NPs are particularly suitable because of their unique physico-chemical properties, in particular plasmonic behaviour that makes them useful as active anticancer agents. These NPs can be obtained by green approaches, alternative to conventional chemical methods, owing to the use of phytochemicals, carbohydrates, and other biomolecules present in plants, fungi, and bacteria, reducing toxic effects. In addition, we analysed the use of green and stimuli-responsive polymeric bio-inspired nanovesicles, mainly used in drug delivery applications that have revolutionised the way of drugs supply. Finally, we reported the last examples on the use of metallic and Au NPs as self-propelling systems as new concept of nanorobot, which are able to respond and move towards specific physical or chemical stimuli in biological entities.

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Biosynthesis and In-vitro Study of Gold Nanoparticles Using Mentha and Pelargonium Extracts

Cited by 48 publications

References 23 publications

Aloe vera leaf extract mediated green synthesis of selenium nanoparticles and assessment of their In vitro antimicrobial activity against spoilage fungi and pathogenic bacteria strains

Aloe vera leaf extract mediated green synthesis of selenium nanoparticles and assessment of their In vitro antimicrobial activity against spoilage fungi and pathogenic bacteria strains

Synthesis of Biogenic Gold Nanoparticles from Terminalia mantaly Extracts and the Evaluation of Their In Vitro Cytotoxic Effects in Cancer Cells

Green Plasmonic Nanoparticles and Bio-Inspired Stimuli-Responsive Vesicles in Cancer Therapy Application

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