Biosurfer for systematic tracking of regulatory mechanisms leading to protein isoform diversity
Mayank Murali,
Jamie Saquing,
Senbao Lu
et al.
Abstract:Long-read RNA sequencing has shed light on transcriptomic complexity, but questions remain about the functionality of downstream protein products. We introduce Biosurfer, a computational approach for comparing protein isoforms, while systematically tracking the transcriptional, splicing, and translational variations that underlie differences in the sequences of the protein products. Using Biosurfer, we analyzed the differences in 32,799 pairs of GENCODE annotated protein isoforms, finding a majority (70%) of v… Show more
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