Biosurfactants from halophilic origin and their potential applications

Citarasu, Thavasimuthu; Thirumalaikumar, Eswaramoorthy; Abinaya, Paramachandran; Babu, Mariavincent Michael; Uma, G.

doi:10.1016/b978-0-12-823380-1.00019-8

Cited by 3 publications

(3 citation statements)

References 216 publications

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“…El biosurfactante obtenido, además de tener actividad superficial podría tener aplicaciones farmacológicas como en la inhibición de la formación de fibrina, lisis de eritrocitos, antitrombóticos e hipocolesterolémico y propiedades antivirales. Los lipopéptidos pueden ser tóxicos cuando tienen la habilidad de solubilizar la bicapa lipídica de la membrana celular (Citarasu et al, 2021). Los biosurfactantes producidos por la especie A. baumannii producen emulsiones aceite en agua, por lo que se facilita la transferencia de petróleo desde la superficie del sistema hasta el seno del mismo.…”

Section: Discussionunclassified

“…Su peso molecular se determinó mediante el índice de saponificación, que tuvo un valor de 173 mg/L, y se obtuvo un peso molecular promedio de 972.8 g/mol, que corresponde a un peso molecular bajo (<1500 g/mol). Los biosurfactantes de bajo peso molecular, como los lipopéptidos, se consideran buenos reductores de la tensión superficial del agua (Citarasu et al, 2021).…”

Section: íNdice De Refracción Ph Densidad Y Peso Molecular Promediounclassified

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Extraction and characterization of a biosurfactant synthesized by Acinotebacter baumannii

Torres-Custodio¹,

Hernández-Rivera²,

López-Lázaro³

et al. 2023

Mexjbiotechnol

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Biosurfactants are metabolites produced by microorganisms during their growth and reproduction. They are amphiphilic molecules capable of modifying surface and interfacial tension. A petrophilic, nitrogen-fixing, phosphorus-solubilizing, and biosurfactant-producing bacterial strain was isolated and characterized. The isolated strain was cultivated in Kim medium with a C:N ratio of 2:1, from which its growth kinetics was determined. Samples of the culture broth were taken at different times and the collapsed drop, oil dispersion and emulsification index tests were performed. Maximum culture growth occurred at 72 h. The biosurfactant was extracted from the crude cell-free broth using a mixture of solvents and a yield of 2.21 g/L was obtained. Thin-layer chromatography and FT-IR analyzes revealed the presence of a lipopeptide biosurfactant. Tensiometry tests showed that the biosurfactant was able to lower the surface tension of water from 72 mN/m to 40 mN/m and the critical micelle concentration was 0.058 (w/w). Probit analysis for toxicity determination showed that there was no weight loss in Eisenia foetida specimens in a range between 10000 and 50000 ppm.

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Section: Discussionunclassified

Section: íNdice De Refracción Ph Densidad Y Peso Molecular Promediounclassified

Extraction and characterization of a biosurfactant synthesized by Acinotebacter baumannii

Torres-Custodio¹,

Hernández-Rivera²,

López-Lázaro³

et al. 2023

Mexjbiotechnol

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“…Peptide molecules from marine diatoms also have been explored with respect to their antioxidant and anticancer properties [133,134]. Biosurfactants from halophiles are receiving more attention for antioxidants, antiviral antibacterial, antifungal, anticancer, antiviral, anti-adhesive, immunomodulator, stimulating dermal fibroblasts, gene therapy, and vaccines [135]. Halophilic bacteria must reach a tipping point in the future by manufacturing various novel drugs, antioxidants, sunscreens, compatible solutes, and hydrolytic enzymes from unexplored regions.…”

Section: Applications and Future Perspectives Of Halophiles As Pharma...mentioning

confidence: 99%

Recent Antimicrobial Responses of Halophilic Microbes in Clinical Pathogens

et al. 2022

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Microbial pathogens that cause severe infections and are resistant to drugs are simultaneously becoming more active. This urgently calls for novel effective antibiotics. Organisms from extreme environments are known to synthesize novel bioprospecting molecules for biomedical applications due to their peculiar characteristics of growth and physiological conditions. Antimicrobial developments from hypersaline environments, such as lagoons, estuaries, and salterns, accommodate several halophilic microbes. Salinity is a distinctive environmental factor that continuously promotes the metabolic adaptation and flexibility of halophilic microbes for their survival at minimum nutritional requirements. A genetic adaptation to extreme solar radiation, ionic strength, and desiccation makes them promising candidates for drug discovery. More microbiota identified via sequencing and ‘omics’ approaches signify the hypersaline environments where compounds are produced. Microbial genera such as Bacillus, Actinobacteria, Halorubrum and Aspergillus are producing a substantial number of antimicrobial compounds. Several strategies were applied for producing novel antimicrobials from halophiles including a consortia approach. Promising results indicate that halophilic microbes can be utilised as prolific sources of bioactive metabolites with pharmaceutical potentialto expand natural product research towards diverse phylogenetic microbial groups which inhabit salterns. The present study reviews interesting antimicrobial compounds retrieved from microbial sources of various saltern environments, with a discussion of their potency in providing novel drugs against clinically drug-resistant microbes.

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