Biosurfactant: Pharmaceutical Perspective

Lahiry, Sandeep

doi:10.15406/japlr.2017.04.00105

Cited by 20 publications

(10 citation statements)

References 24 publications

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“…The harmful nature of SARS-CoV-2 is dependent on the integrity of its lipidic envelope, which encloses vital proteins and RNA [ 143 ]. The amphiphilic nature of BS allows them to interact directly with the lipid membrane of the coronavirus, breaking up the virus structure and, therefore, diminishing its infectivity [ 144 ].…”

Section: Antiviral Activitymentioning

confidence: 99%

Recent Advances in Biomedical, Therapeutic and Pharmaceutical Applications of Microbial Surfactants

et al. 2021

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The spread of antimicrobial-resistant pathogens typically existing in biofilm formation and the recent COVID-19 pandemic, although unrelated phenomena, have demonstrated the urgent need for methods to combat such increasing threats. New avenues of research for natural molecules with desirable properties to alleviate this situation have, therefore, been expanding. Biosurfactants comprise a group of unique and varied amphiphilic molecules of microbial origin capable of interacting with lipidic membranes/components of microorganisms and altering their physicochemical properties. These features have encouraged closer investigations of these microbial metabolites as new pharmaceutics with potential applications in clinical, hygiene and therapeutic fields. Mounting evidence has indicated that biosurfactants have antimicrobial, antibiofilm, antiviral, immunomodulatory and antiproliferative activities that are exploitable in new anticancer treatments and wound healing applications. Some biosurfactants have already been approved for use in clinical, food and environmental fields, while others are currently under investigation and development as antimicrobials or adjuvants to antibiotics for microbial suppression and biofilm eradication strategies. Moreover, due to the COVID-19 pandemic, biosurfactants are now being explored as an alternative to current products or procedures for effective cleaning and handwash formulations, antiviral plastic and fabric surface coating agents for shields and masks. In addition, biosurfactants have shown promise as drug delivery systems and in the medicinal relief of symptoms associated with SARS-CoV-2 acute respiratory distress syndrome.

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Section: Antiviral Activitymentioning

confidence: 99%

Recent Advances in Biomedical, Therapeutic and Pharmaceutical Applications of Microbial Surfactants

et al. 2021

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“…Moreover, biosurfactants are promising for cosmetic applications. According to recent publications, they have lower toxicity, offering dermal compatibility and moisturizing effects [ 124 ]. Ferreira et al, 2017 [ 125 ] described a demand for green cosmetics to replace petroleum derivates.…”

Section: Applicationsmentioning

confidence: 99%

Biosurfactants: Properties and Applications in Drug Delivery, Biotechnology and Ecotoxicology

et al. 2021

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Surfactants are amphiphilic compounds having hydrophilic and hydrophobic moieties in their structure. They can be of synthetic or of microbial origin, obtained respectively from chemical synthesis or from microorganisms’ activity. A new generation of ecofriendly surfactant molecules or biobased surfactants is increasingly growing, attributed to their versatility of applications. Surfactants can be used as drug delivery systems for a range of molecules given their capacity to create micelles which can promote the encapsulation of bioactives of pharmaceutical interest; besides, these assemblies can also show antimicrobial properties. The advantages of biosurfactants include their high biodegradability profile, low risk of toxicity, production from renewable sources, functionality under extreme pH and temperature conditions, and long-term physicochemical stability. The application potential of these types of polymers is related to their properties enabling them to be processed by emulsification, separation, solubilization, surface (interfacial) tension, and adsorption for the production of a range of drug delivery systems. Biosurfactants have been employed as a drug delivery system to improve the bioavailability of a good number of drugs that exhibit low aqueous solubility. The great potential of these molecules is related to their auto assembly and emulsification capacity. Biosurfactants produced from bacteria are of particular interest due to their antibacterial, antifungal, and antiviral properties with therapeutic and biomedical potential. In this review, we discuss recent advances and perspectives of biosurfactants with antimicrobial properties and how they can be used as structures to develop semisolid hydrogels for drug delivery, in environmental bioremediation, in biotechnology for the reduction of production costs and also their ecotoxicological impact as pesticide alternative.

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“…The low molecular weight biosurfactants are more effective at reducing surface and interfacial tensions whereas high molecular weight biosurfactants are better emulsifiers [ 19 ]. Each of these groups are further categorized into different classes based on their chemical composition [ 26 , 27 ]. The major classes of low molecular weight biosurfactants include glycolipids, lipopeptides, glycopeptides and phospholipids while high molecular weight biosurfactants include lipoproteins, polysaccharide-protein-fatty acid complexes and lipopolysaccharide-protein complexes [ 19 , 28 , 29 ].…”

Section: Classification Of Biosurfactantsmentioning

confidence: 99%

Microbial Biosurfactants in Cosmetic and Personal Skincare Pharmaceutical Formulations

et al. 2020

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Cosmetic and personal care products are globally used and often applied directly on the human skin. According to a recent survey in Europe, the market value of cosmetic and personal care products in Western Europe reached about 84 billion euros in 2018 and are predicted to increase by approximately 6% by the end of 2020. With these significant sums of money spent annually on cosmetic and personal care products, along with chemical surfactants being the main ingredient in a number of their formulations, of which many have been reported to have the potential to cause detrimental effects such as allergic reactions and skin irritations to the human skin; hence, the need for the replacement of chemical surfactants with other compounds that would have less or no negative effects on skin health. Biosurfactants (surfactants of biological origin) have exhibited great potential such as lower toxicity, skin compatibility, protection and surface moisturizing effects which are key components for an effective skincare routine. This review discusses the antimicrobial, skin surface moisturizing and low toxicity properties of glycolipid and lipopeptide biosurfactants which could make them suitable substitutes for chemical surfactants in current cosmetic and personal skincare pharmaceutical formulations. Finally, we discuss some challenges and possible solutions for biosurfactant applications.

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Biosurfactant: Pharmaceutical Perspective

Cited by 20 publications

References 24 publications

Recent Advances in Biomedical, Therapeutic and Pharmaceutical Applications of Microbial Surfactants

Recent Advances in Biomedical, Therapeutic and Pharmaceutical Applications of Microbial Surfactants

Biosurfactants: Properties and Applications in Drug Delivery, Biotechnology and Ecotoxicology

Microbial Biosurfactants in Cosmetic and Personal Skincare Pharmaceutical Formulations

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