Biosurfactant-mediated biosynthesis of CuO nanoparticles and their antimicrobial activity

Athira, K.; Gurrala, Lakshmiprasad; Kumar, Darbha V. Ravi

doi:10.1007/s13204-021-01766-y

Cited by 24 publications

(7 citation statements)

References 67 publications

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“…The nanoparticles exhibited excellent antimicrobial activity against both bacteria and fungi, with a minimum inhibition concentration (MIC) of 7.8 µg/ml. The findings suggest that rhamnolipids can be beneficial in formulating antimicrobial and antiviral formulations [82]. The collective results from these studies indicate that rhamnolipids play a crucial role in the synthesis and stabilization of metal nanoparticles.…”

Section: Silver/cuo Nanoparticlesmentioning

confidence: 90%

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Biosurfactants: Sustainable Alternative to Synthetic Surfactants and Their Applications

POOMALAI,

KRISHNAN,

RAVICHANDRAN

et al. 2024

Int J App Pharm

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Biosurfactants are surface active agents produced by microorganisms, which help reduce surface or interfacial tension between two immiscible liquids like oil and water. In recent years, Due to their environmentally friendly nature and wide range of applications in various industries, they can act as a sustainable alternative to synthetic surfactants. This review article provides an overview of biosurfactants, emphasizing their need for biosurfactants, the production process, and their classification based on molecular weight, charge, and the microorganism they derived. The advantages include biodegradability, biocompatibility, low toxicity, surface activity, and specificity, and various areas where the biosurfactant used are emulsification, thermal stability, pH stability, wetting ability, foaming ability, and spreadability. Research on using biosurfactants in various formulations like nanoparticles, liposomes, transdermal application, nanoemulsion, and nanocapsules is also highlighted in this review to support its application in the medical field. Biosurfactants are also utilized in various fields like the pharmaceuticals, cosmetics, food, and oil industries. However, they have their drawbacks, which include high production costs, variability in production yield, sensitivity to the environment, lack of standardization, hurdles in regulatory approval, and research and development limitations. Despite certain drawbacks, biosurfactant offers a sustainable alternative to synthetic surfactants.

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Section: Silver/cuo Nanoparticlesmentioning

confidence: 90%

“…In another study by K. Athira et al (2021), CuO nanoparticles were biosynthesized using rhamnolipids via a hydrothermal method. Characterization was conducted through FTIR, TGA, XRD, SEM, and TEM.…”

Section: Silver/cuo Nanoparticlesmentioning

confidence: 99%

Biosurfactants: Sustainable Alternative to Synthetic Surfactants and Their Applications

POOMALAI,

KRISHNAN,

RAVICHANDRAN

et al. 2024

Int J App Pharm

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“…Afterward, the purified sample was dried in an oven at 70 °C for overnight. The resulting powder from the drying process was then utilized for characterization purposes [23].…”

Section: Synthesis Of Rhamnolipid-capped Copper Oxidementioning

confidence: 99%

Biosurfactant-capped CuO nanoparticles coated cotton/polypropylene fabrics toward antimicrobial textile applications

Haripriya,

Revathy,

Kumar

et al. 2024

Nanotechnology

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The global COVID-19 pandemic has led to an increase in the importance of implementing effective measures to prevent the spread of microorganisms. Consequently, there is a growing demand for antimicrobial materials, specifically antimicrobial textiles and face masks, because of the surge in diseases caused by bacteria and viruses like SARS-CoV-2. Face masks that possess built-in antibacterial properties can rapidly deactivate microorganisms, enabling reuse and reducing the incidence of illnesses. Among the numerous types of inorganic nanomaterials, copper oxide nanoparticles (CuO NPs) have been identified as cost-effective and highly efficient antimicrobial agents for inactivating microbes. Furthermore, biosurfactants have recently been recognized for their potential antimicrobial effects, in addition to inorganic nanoparticles. Therefore, this research's primary focus is synthesizing biosurfactant-mediated CuO NPs, integrating them into natural and synthetic fabrics such as cotton and polypropylene and evaluating the resulting fabrics' antimicrobial activity. Using rhamnolipid (RL) as a biosurfactant and employing a hydrothermal method with a pH range of 9-10, RL capped CuO NPs are synthesized (RL-CuO NPs). To assess their effectiveness against gram-positive (Staphylococcus aureus) and gram-negative (Escherichia coli) microorganisms, the RL-CuO NPs are subjected to antibacterial testing. The RL-capped CuO NPs exhibited antimicrobial activity at much lower concentrations than the individual RL, CuO. RL-CuO NPs have shown a minimum inhibitory concentration (MIC) of 1.2 mg/mL and minimum bactericidal concentration (MBC) of 1.6 mg/mL for E. coli and a minimum inhibitory concentration (MIC) of 0.8 mg/mL and a minimum bactericidal concentration (MBC) of 1.2 mg/mL for S. aureus, respectively. Furthermore, the developed RL-CuO NPs are incorporated into cotton and polypropylene fabrics using a screen-printing technique. Subsequently, the antimicrobial activity of the coated fabrics is re-evaluated, revealing that RL CuO NPs coated fabrics exhibited remarkable antibacterial properties against both gram-positive and gram-negative bacteria.

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“…In another study, rhamnolipids were applied to synthesise CuO nanoparticles to counteract multi-drug-resistant pathogens. RL-CuO NPs showed excellent antibacterial activity both against Gram-positive strains, such as Streptococcus mutans , S. aureus and Enterococcus faecalis , and Gram-negative strains, such as Shigella dysentriae and Salmonella typhi , with MIC values at concentrations around 7.8 µg/mL and 250 µg/mL, respectively, demonstrating that RL and CuO NPs can combine their activities in synergy to increase cell membrane permeability and promote bacterial cell inactivation [ 144 ].…”

Section: Utilizing Biosurfactants As Adjuvants In Medicine: Drug Deli...mentioning

confidence: 99%

Harnessing the Potential of Biosurfactants for Biomedical and Pharmaceutical Applications

Ceresa,

Fracchia,

Sansotera

et al. 2023

Pharmaceutics

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Biosurfactants (BSs) are microbial compounds that have emerged as potential alternatives to chemical surfactants due to their multifunctional properties, sustainability and biodegradability. Owing to their amphipathic nature and distinctive structural arrangement, biosurfactants exhibit a range of physicochemical properties, including excellent surface activity, efficient critical micelle concentration, humectant properties, foaming and cleaning abilities and the capacity to form microemulsions. Furthermore, numerous biosurfactants display additional biological characteristics, such as antibacterial, antifungal and antiviral effects, and antioxidant, anticancer and immunomodulatory activities. Over the past two decades, numerous studies have explored their potential applications, including pharmaceuticals, cosmetics, antimicrobial and antibiofilm agents, wound healing, anticancer treatments, immune system modulators and drug/gene carriers. These applications are particularly important in addressing challenges such as antimicrobial resistance and biofilm formations in clinical, hygiene and therapeutic settings. They can also serve as coating agents for surfaces, enabling antiadhesive, suppression, or eradication strategies. Not least importantly, biosurfactants have shown compatibility with various drug formulations, including nanoparticles, liposomes, micro- and nanoemulsions and hydrogels, improving drug solubility, stability and bioavailability, and enabling a targeted and controlled drug release. These qualities make biosurfactants promising candidates for the development of next-generation antimicrobial, antibiofilm, anticancer, wound-healing, immunomodulating, drug or gene delivery agents, as well as adjuvants to other antibiotics. Analysing the most recent literature, this review aims to update the present understanding, highlight emerging trends, and identify promising directions and advancements in the utilization of biosurfactants within the pharmaceutical and biomedical fields.

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Biosurfactant-mediated biosynthesis of CuO nanoparticles and their antimicrobial activity

Cited by 24 publications

References 67 publications

Biosurfactants: Sustainable Alternative to Synthetic Surfactants and Their Applications

Biosurfactants: Sustainable Alternative to Synthetic Surfactants and Their Applications

Biosurfactant-capped CuO nanoparticles coated cotton/polypropylene fabrics toward antimicrobial textile applications

Harnessing the Potential of Biosurfactants for Biomedical and Pharmaceutical Applications

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