Biosupramolecular networks: Taking inspiration from nature to create powerful synthetic platforms

Watson, Emma E.; Winssinger, Nicolas

doi:10.1016/j.cbpa.2021.102104

Cited by 3 publications

(4 citation statements)

References 60 publications

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“…Artificial molecular devices inspired by biomolecular mechanisms are expected to be useful for obtaining spatiotemporal control of artificial and biological cell activities. [119] However, none of these devices can be produced on site or used repeatedly. For chemical AI applications that require recursiveness of the system, it is necessary to develop tough and resettable devices for repeated use.…”

Section: Information Transmission Technology For Cellular Chemical Aimentioning

confidence: 99%

Molecular Cybernetics: Challenges toward Cellular Chemical Artificial Intelligence

Murata

Toyota

Nomura

et al. 2022

Adv Funct Materials

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Research on so-called "chemical artificial intelligence" (CAI) is an emerging field with the aim of constructing information-processing systems with learning capabilities based on chemical methodologies. This can be regarded as an attempt to reconstruct Cybernetics using molecular based systems. Many chemical reaction systems with computational abilities are proposed, but most are fixed functions that deliver molecular output for a given molecular input. On the other hand, chemical AI is a system with learning capability; namely, the output should be variable and gradually change upon repeated molecular inputs. In this paper, a compartmentalization approach for implementing cellular chemical AI using liposomes is discussed. The existing studies in terms of the methods used for assembling systems consisting of many liposomes with different functions, methods for achieving recursiveness and plasticity in chemical reaction systems, and methods for reconfiguring the network topology by liposome deformation are reviewed. Issues that must be addressed in order to realize chemical AI are also identified.

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Section: Information Transmission Technology For Cellular Chemical Aimentioning

confidence: 99%

Molecular Cybernetics: Challenges toward Cellular Chemical Artificial Intelligence

Murata

Toyota

Nomura

et al. 2022

Adv Funct Materials

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show abstract

“…1−4 Understanding and manipulating the fundamental input-to-output processes in biology has emerged as an attractive platform for creating biological circuits with new functions, holding promise for applications in smart diagnostics and therapeutic systems. 5 In circuit construction, various outputs are connected to inputs for functionality. For instance, fluorescent, 1,6−12 bioluminescent, 13−15 colorimetric, 16−19 and electrochemical 20−22 outputs have been used to detect bioanalytes.…”

Section: ■ Introductionmentioning

confidence: 99%

“…Life relies on a series of complex biomolecular interactions that lead to essential biological phenomena. Similar to computation circuits, biological processes consist of logical operations that use specific molecular recognitions as input, producing a certain form of output through structural or chemical transformations. − Understanding and manipulating the fundamental input-to-output processes in biology has emerged as an attractive platform for creating biological circuits with new functions, holding promise for applications in smart diagnostics and therapeutic systems …”

Section: Introductionmentioning

confidence: 99%

Facile Strategy to Output Fluorescein from Nucleic Acid Interactions

Kim,

Jang,

Chang

et al. 2023

Bioconjugate Chem.

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Biomolecular operations, which involve the conversion of molecular signals or interactions into specific functional outputs, are fundamental to the field of biology and serve as the important foundation for the design of diagnostic and therapeutic systems. To maximize their functionalities and broaden their applicability, it is crucial to develop novel outputs and facile chemical transformation methods. With this aim, in this study, we present a straightforward method for converting nucleic acid signals into fluorescein outputs that exhibit a wide range of functionalities. This operation is designed through a DNA-templated reaction based on riboflavin-photocatalyzed oxidation of dihydrofluorescein, which is readily prepared by simple NaBH4 reduction of the fluorescein with no complicated chemical caging steps. The templated photooxidation exhibits high efficiency (k app = 2.7 × 10–3/s), generating a clear fluorescein output signal distinguishable from a low background, originating from the high stability of the synthesized dihydrofluorescein. This facile and efficient operation allows the nucleic acid-initiated activation of various fluorescein functions, such as fluorescence and artificial oxidase activity, which are applied in the design of novel bioanalytical systems, including fluorescent and colorimetric DNA sensors. The operation presented herein would expand the scope of biomolecular circuit systems for diagnostic and therapeutic applications.

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“…18 It is worthy to mention that the supramolecular co-assembly approach turns out to be an attractive tool for generating application-oriented diverse biomimetic nanostructures to catalyst, ranging from peptidoglycan mimic, photoredox catalyst, to erasable ink. [18][19][20][21][22][23][24] However, in a complex biosupramolecular assembly associated with binding and catalysis of oligonucleotide substrates has not been explored. In fact, this strategy remains unexplored in developing the biocatalyst where the substrate and enzyme can both co-assemble in modulating the structural aspect of the whole ensemble and functionality of the enzyme.…”

Section: Introductionmentioning

confidence: 99%

Co-assembly-mediated biosupramolecular catalysis: thermodynamic insights into nucleobase specific (oligo)nucleotide attachment and cleavage

Priyanka,

Maiti

2023

J. Mater. Chem. B

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Biosupramolecular networks: Taking inspiration from nature to create powerful synthetic platforms

Cited by 3 publications

References 60 publications

Molecular Cybernetics: Challenges toward Cellular Chemical Artificial Intelligence

Molecular Cybernetics: Challenges toward Cellular Chemical Artificial Intelligence

Facile Strategy to Output Fluorescein from Nucleic Acid Interactions

Co-assembly-mediated biosupramolecular catalysis: thermodynamic insights into nucleobase specific (oligo)nucleotide attachment and cleavage

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