Biostability of γ-Fe2O3 nano particles Evaluated using an in vitro cytotoxicity assays on various tumor cell lines

Lee, Kwon-Jai; An, Jeung-Hee; Shin, Jae-Suk; Kim, Dong‐Hee; Yoo, Hwa‐Seung; Cho, Chong-Kwan

doi:10.1016/j.cap.2010.08.022

Cited by 14 publications

(3 citation statements)

References 20 publications

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“…This biopolymer containing polyglucose, it is at the head of the polymers that are to be studied in drug delivery systems because of its plasma-expanding properties, desirable physicochemical properties, low cost of ownership, and attractive clinical traits. In the study by Singh et al, uncoated magnetite, uncoated maghemite, dextran-coated magnetite, and dextrancoated maghemite particles were studied comparatively in terms of cytotoxicity and were seen that the samples did not show cytotoxicity under 100 mg/mL (Singh et al 2012;Lee et al 2011;Pisanic et al 2007). Dextran biopolymer and derivatives are widely used for in the biomedical applications and chemical conjugation because of their excellent properties such as water solubility, biodegradability, biocompatibility, and non-fouling (McIntosh et al 1997;Shahnaz et al 2010;Sun et al 2010;Thambi et al 2014).…”

Section: Introductionmentioning

confidence: 99%

Synthesis and characterization of new branched magnetic nanocomposite for loading and release of topotecan anti-cancer drug

Tarhan

Tural

2019

J Anal Sci Technol

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The purpose of this study is to synthesize the new branched magnetic nanocomposite to carry the therapeutic agents and bio-macromolecules. Although topotecan (TPT) has significant antitumor activity to lung, ovarian, breast, pancreas, and stomach cancers, lactone ring opening causes a reduction in cytotoxic activity and severe side effects in physiological conditions. In order to contribute to the removal of the handicap (lactone ring opening), magnetic dextran branched with NαNα-Bis (carboxymethyl)-L-lysine hydrate (NTA) nanoparticles (MD 3) were prepared. The characterization of the resulting MD 3 material was done by using multi-pronged analyses. The stability and release of TPT with synthesized and characterized new material of the MD 3 was studied using various essential factors like concentration, dosage, pH, and time. The entrapment efficiency and loading capacity of TPT onto MD 3 was calculated as 32.2% and 1.44 mg/g, respectively, at pH 5. Release studies were performed with drug-loaded MD 3 at different pH values. It was seen that the best release was obtained at the cancerous site pH. Initial drug concentration was measured as 0.118 mM. The loaded drug concentration was calculated as 0.0380 mM at pH 5 and 0.00092 mM of drug was released after 90 min at pH 5.8. Percentage released of drug was found as 2.42% during 90 min.

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Section: Introductionmentioning

confidence: 99%

Synthesis and characterization of new branched magnetic nanocomposite for loading and release of topotecan anti-cancer drug

Tarhan

Tural

2019

J Anal Sci Technol

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“…Current strategies for cancer treatment are based on the removal of cancer cells through surgery. To reduce the risk of recurrence by residual cancer cells, an adjuvant treatment is used that consists of radio-radiation, chemotherapy, or proton beam and magnetic nanoparticles [ 2 – 4 ]. However, adjuvant treatments such as chemotherapeutic drugs have side effects as they may also kill normal cells or mistakenly target noncancerous cells due to their high proliferation.…”

Section: Introductionmentioning

confidence: 99%

Effects of a Nonthermal Atmospheric Pressure Plasma Jet on Human Gingival Fibroblasts for Biomedical Application

Lee

Kim

2016

BioMed Research International

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Nonthermal atmospheric pressure plasma jets (APPJ) have been developed and applied in biomedical research as a cancer treatment or bacterial sterilization. However, the drawback of APPJ on normal oral cells during plasma treatment and underlying cell death mechanisms have not been studied and clearly explained, although there is known to be an influence from reactive oxygen species (ROS). Hence, this study investigates whether and how a nonthermal atmospheric pressure air plasma jet kills human normal gingival cells using immortalized human gingival fibroblasts (hTERT-hNOF cells). In this study, a set of physicochemical or biological methods were used to illuminate the killing mechanisms. It was found that ROS were induced intracellularly without a breakdown of the cell wall and apoptosis was involved in cell death when an air APPJ treatment was performed on the cells directly without media; the air treatment only supported a detachment of the cells without increase of ROS. It was also revealed that a correlation between intracellular ROS concentration and cells viability existed. These results indicated that the direct air APPJ treatment possibly raises safety issue to normal tissue and thereby APPJ application in biomedical field needs more in vitro and in vivo study to optimize it.

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“…Current treatment strategy for cancer is based on surgery to remove cancer cells. In order to eradicate residual cancer cells to reduce the risk of recurrence, an adjuvant therapy after curative surgery is used [1]- [4]. However, adjuvant treatments such as chemotherapeutic drugs have negative side effects as they also kill normal cells due to their high proliferation.…”

Section: Introductionmentioning

confidence: 99%

Effects of a Nonthermal Atmospheric Pressure Plasma Discharged in Cell Culture Medium on Melanoma Cell

Chuang¹,

Wang²,

Chen³

2019

IJBBB

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Cold atmosphere plasma has been developed and applied as a novel technology for cancer treatment. In most researches cap was directly applied to irradiate cancer cells or tissues. In this study, we report that CAP plasma discharge in cell culture medium and studied its effects on melanoma cancer cells. CAP plasma treated cell culture medium was applied to melanoma and fibroblast cells. Cell viability test by using MTT assay showed that treatment of with CAP plasma had the strongest effect on inducing apoptosis to inhibit melanoma cell proliferation and further cell metastasis. The most important is that CAP plasma treatment do not have any harmful effect on normal fibroblast cell, but do have exhibited strong cell killing effect on B16/F10 melanoma cell.

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Biostability of γ-Fe2O3 nano particles Evaluated using an in vitro cytotoxicity assays on various tumor cell lines

Cited by 14 publications

References 20 publications

Synthesis and characterization of new branched magnetic nanocomposite for loading and release of topotecan anti-cancer drug

Synthesis and characterization of new branched magnetic nanocomposite for loading and release of topotecan anti-cancer drug

Effects of a Nonthermal Atmospheric Pressure Plasma Jet on Human Gingival Fibroblasts for Biomedical Application

Effects of a Nonthermal Atmospheric Pressure Plasma Discharged in Cell Culture Medium on Melanoma Cell

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