Biosimilar FSH Preparations Versus Highly Purified Urinary FSH for Simple Ovulation Induction in Infertile Women with Polycystic Ovary Syndrome

Abstract

Polycystic ovary syndrome (PCOS) is considered as an endocrine disorder which affects about 5% to 10% of all females. All races and nationalities are affected and represent the commonest hormonal disorder in the women reproductive age and are considered the most common cause of female infertility [1]. For >30 years, gonadotropins have been used a crucial element in pharmacological ovarian stimulation drugs in assisted reproductive technology (ART) in the primary and secondary infertility and in the treatment of hypogonadotropic hypogonadism [2].Highly purified (HP) urinary FSH has been manufactured by the use of the monoclonal antibodies which is specific to FSH. Highly purified urinary FSH preparations contain < 0.1 IU LH and the FSH specific activity is 10,000 IU/mg protein, it contains less than 5% unidentified urinary proteins [3]. Lack of urinary proteins in HP-uFSH diminishes the adverse reactions like hypersensitivity or local Allergy [4,5], while LH absence has no negative impact in the ovarian stimulation in PCOS infertile women [6,7].