Biosensors: NIR Biosensing of Neurotransmitters in Stem Cell‐Derived Neural Interface Using Advanced Core–Shell Upconversion Nanoparticles (Adv. Mater. 14/2019)

Chiral Core–Shell Upconversion Nanoparticle@MOF Nanoassemblies for Quantification and Bioimaging of Reactive Oxygen Species in Vivo

“…The lanthanide-doped upconversion nanoparticles (UCNPs) that can convert near-infrared radiation into visible light have been widely utilized in constructing probes. − Zeolitic imidazolate framework-8 (ZIF-8) is a subclass of metal–organic framework (MOF) with excellent biocompatibility and tunable pore openings. − Notably, integrating UCNPs with chiral NPs is a good strategy for the creation of composite nanoassembliess, which can possibly utilize both CD and upconversion luminescent (UCL) signals. The MOF could be used as a good bridge to combine both functional nanomaterials into one system.…”

Exploring the use of upconversion nanoparticles in chemical and biological sensors: from surface modifications to point-of-care devices

“…22B . 130 Based on very similar strategies, Er and Tm-doped UCNPs have been combined with GO for biosensing Alzheimer's disease and prostate cancer biomarkers, 100 detection of dopamine released from stem cell derived dopaminergic-neurons, 203 clenbuterol, 204 carcinoembryonic antigen (CEA), 205 endonuclease, 99 topoisomerases in cell extracts, 84 glycoprotein, 206 metalloproteinase-9 in living cells, 131 and also for sensing nutritional deficiencies in crops. 101 …”

Microsphere Photonic Superlens for a Highly Emissive Flexible Upconversion-Nanoparticle-Embedded Film

“…Generally, there are three main pathways to strengthen the multiphoton upconversion processes: (i) nanoparticle engineering, (ii) metallic plasmonic enhancement, and (iii) dielectric photonic mediation. The purpose of nanoparticle engineering is to boost the absorption cross section and radiative emission rates by codoping of Li + , Eu 2+ , Bi 3+ , Fe 3+ , and Sc 3+ , surface passivation shelling, − energy transfer modulation, and broadband dye sensitization. − The metallic enhancement stems from localized surface plasmon resonances on metallic nanostructures, where excitation light is confined in an ultrasmall mode volume for high photon density of states achieving a large absorption cross section. The electric field intensity in the vicinity of plasmonic nanostructures can be enhanced by over 10 2 -fold, leading to an enhancement ratio up to 10 2 n (where n is the number of photons involved in the upconversion process) .…”