Biosensors in diagnosing COVID-19 and recent development

The on-going SARS-CoV-2 causing COVID-19 discovered in December 2019, is responsible for a global pandemic. The virus belongs to the group of enveloped viruses containing linear, non-segmented, single stranded, positive sense strand RNA as genetic material. Already six different strains Coronaviruses are being reported to infect humans, however the seventh one is genetically similar to the SARS Coronavirus and termed as SARS-CoV-2. Specific crucial macromolecules such as membrane, nuclear, spike and enveloped proteins including HE esterase are present in the virus that interact with ACE2, APN, NEU-5, 9SC2 moiety of humans plays significant role in occurrence and transmission of the devastating disease. This review article summarizes the structure, histopathology, transmission of novel Coronavirus, its symptoms with preventive measures & currently prescribed drugs. Though various drugs and therapy have been administrated or implemented to restrict COVID-19, however it is imperative to develop an antidote against SARS-CoV-2 by the scientific or research community to save life.

show abstract

“… 4 ; 5 ; 6 ; 7 ; 8 ; 9 ; 10 ; 11 ; 15 ; 25 ; 26 ; 33 ; 34 ; 36 ; 37 ; 38 ; 39 ; 43 ; 44 ; 47 ; 48 ; 49 ; 50 ; 54 .…”

Section: Uncited Referencesunclassified

“Update vision on COVID-19: Structure, immune pathogenesis, treatment and safety assessment”

Agrahari¹,

Mohanty²,

Vishwakarma³

et al. 2021

Sensors International

View full text Add to dashboard Cite

show abstract

“…As it is investigated that COVID-19 affects the upper respiratory system, these digital sensors monitor the respiration process in an individual in most effective way [ 91 ]. Additionally, these sensors can detect other symptoms of COVID-19 as well like cough, cold and fever [ 92 ]. Various advancements of wearable sensors are available in market such as Huami device which is utilized for indicating fever, cardiac rhythm and heart rate [ 93 ].…”

Section: Biosensors For Covid-19mentioning

confidence: 99%

Critical neurological features of COVID-19: Role of imaging methods and biosensors for effective diagnosis

Singh¹,

Allawadhi²,

Khurana³

et al. 2021

Sensors International

View full text Add to dashboard Cite

COVID-19 is a respiratory infection that has been declared as a global health crisis by the WHO. It mainly affects the respiratory system. Apart from respiratory system, it also affects other organs as well including the brain. Numerous emerging reports have demonstrated that the COVID-19 has detrimental effects on neurological functions, and can lead to severe impairment of the nervous system. The neurological manifestations linked with COVID-19 include headache, anosmia, encephalitis, epileptic seizures, Guillain-Barre syndrome, stroke and intracerebral hemorrhage alongwith multiple others complications. The CNS related complications may be severe are they are linked with poor diagnosis which may worsen the condition. Therefore, there is a need to precisely understand the neurological sequelae along with upcoming clinical outcomes. Here, we presented a brief review of neurological complications and symptoms associated with COVID-19 along with brain imaging findings. Further, we have discussed about the emerging biosensing approaches which may aid in rapid, precise and mass diagnosis of COVID-19.

show abstract

“…The testing for the infection will differ based on the country (Dong et al 2020 ). Several biosensors have been developed and identified for early SARS-CoV-2 detection (Behera et al 2020 ).…”

Section: Sars-cov-2 Detectionmentioning

confidence: 99%

A review of novel coronavirus disease (COVID-19): based on genomic structure, phylogeny, current shreds of evidence, candidate vaccines, and drug repurposing

et al. 2021

View full text Add to dashboard Cite

Coronavirus disease (COVID-19) pandemic is instigated by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). As of March 13, 2021, more than 118.9 million cases were infected with COVID-19 worldwide. SARS-CoV-2 is a positive-sense single-stranded RNA beta-CoV. Most COVID-19 infected individuals recover within 1–3 weeks. Nevertheless, approximately 5% of patients develop acute respiratory distress syndrome and other systemic complications, leading to death. Structural genetic analyses of SARS-CoV-2 have shown genomic resemblances but a low evolutionary correlation to SARS-CoV-1 responsible for the 2002–2004 outbreak. The S glycoprotein is critical for cell adhesion and the entrance of the virus into the host. The process of cell entry uses the cellular receptor named angiotensin-converting enzyme 2. Recent evidence proposed that the CD147 as a SARS-CoV-2′s potential receptor. The viral genome is mainly held by two non-structural proteins (NSPs), ORF1a and ORF1ab, along with structural proteins. Although NSPs are conserved among the βCoVs, mutations in NSP2 and NSP3 may play critical roles in transmitting the virus and cell tropism. To date, no specific/targeted anti-viral treatments exist. Notably, more than 50 COVID-19 candidate vaccines in clinical trials, and a few being administered. Preventive precautions are the primary strategy to limit the viral load transmission and spread, emphasizing the urgent need for developing significant drug targets and vaccines against COVID-19. This review provides a cumulative overview of the genomic structure, transmission, phylogeny of SARS-CoV-2 from Indian clusters, treatment options, updated discoveries, and future standpoints for COVID-19. Supplementary Information The online version contains supplementary material available at 10.1007/s13205-021-02749-0.

show abstract

Biosensors in diagnosing COVID-19 and recent development

Cited by 40 publications

References 51 publications

“Update vision on COVID-19: Structure, immune pathogenesis, treatment and safety assessment”

“Update vision on COVID-19: Structure, immune pathogenesis, treatment and safety assessment”

Critical neurological features of COVID-19: Role of imaging methods and biosensors for effective diagnosis

A review of novel coronavirus disease (COVID-19): based on genomic structure, phylogeny, current shreds of evidence, candidate vaccines, and drug repurposing

Contact Info

Product

Resources

About