Biosensors for psychiatric biomarkers in mental health monitoring

Wang, Lin; Hu, Yubing; Jiang, Nan; Yetisen, Ali K.

doi:10.1016/j.bios.2024.116242

Cited by 4 publications

(1 citation statement)

References 236 publications

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“…In recent decades, the assessment of the EPI level in various biological samples like blood, urine, and cerebrospinal fluid has become a center of interest owing to the sharp increase worldwide in neurological disorders such as schizophrenia, depression, anxiety, insomnia, Parkinson's, and Alzheimer's diseases [18]. EPI belongs to the catecholamines and includes a catechol moiety that is exploited as an electrochemical label for its quantification [19][20][21][22].…”

Section: Introductionmentioning

confidence: 99%

MeNPs-PEDOT Composite-Based Detection Platforms for Epinephrine and Quercetin

Leau,

Marin,

Toader

et al. 2024

Biosensors

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The development of low-cost, sensitive, and simple analytical tools for biomolecule detection in health status monitoring is nowadays a growing research topic. Sensing platforms integrating nanocomposite materials as recognition elements in the monitoring of various biomolecules and biomarkers are addressing this challenging objective. Herein, we have developed electrochemical sensing platforms by means of a novel fabrication procedure for biomolecule detection. The platforms are based on commercially available low-cost conductive substrates like glassy carbon and/or screen-printed carbon electrodes selectively functionalized with nanocomposite materials composed of Ag and Au metallic nanoparticles and an organic polymer, poly(3,4-ethylenedioxythiophene). The novel fabrication method made use of alternating currents with controlled amplitude and frequency. The frequency of the applied alternating current was 100 mHz for the polymer deposition, while a frequency value of 50 mHz was used for the in situ electrodeposition of Ag and Au nanoparticles. The selected frequency values ensured the successful preparation of the composite materials. The use of readily available composite materials is intended to produce cost-effective analytical tools. The judicious modification of the organic conductive matrix by various metallic nanoparticles, such as Ag and Au, extends the potential applications of the sensing platform toward a range of biomolecules like quercetin and epinephrine, chosen as benchmark analytes for proof-of-concept antioxidant and neurotransmitter detection. The sensing platforms were tested successfully for quercetin and epinephrine determination on synthetic and real samples. Wide linear response ranges and low limit-of-detection values were obtained for epinephrine and quercetin detection.

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