Biosensors for endocrine disruptors

Eltzov, Evgeni; Kushmaro, Ariel; Marks, Robert S.

doi:10.1533/9781845695743.2.183

Cited by 7 publications

(4 citation statements)

References 170 publications

(163 reference statements)

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“…Therefore, detection of organic compounds using these bioassays is activity—rather than structure-oriented. Cell-based reporter gene assays for EDCs including bioluminescent bioassays are routinely reviewed in the literature (for recent examples see [96, 97]) and are summarized here in Table 3.…”

Section: Evaluation Of Organic Toxicant-induced Health Risks Using mentioning

confidence: 99%

Detection of Organic Compounds with Whole-Cell Bioluminescent Bioassays

Smartt

et al. 2014

Advances in Biochemical Engineering/Biotechnology

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Natural and manmade organic chemicals are widely deposited across a diverse range of ecosystems including air, surface water, groundwater, wastewater, soil, sediment, and marine environments. Some organic compounds, despite their industrial values, are toxic to living organisms and pose significant health risks to humans and wildlife. Detection and monitoring of these organic pollutants in environmental matrices therefore is of great interest and need for remediation and health risk assessment. Although these detections have traditionally been performed using analytical chemical approaches that offer highly sensitive and specific identification of target compounds, these methods require specialized equipment and trained operators, and fail to describe potential bioavailable effects on living organisms. Alternatively, the integration of bioluminescent systems into whole-cell bioreporters presents a new capacity for organic compound detection. These bioreporters are constructed by incorporating reporter genes into catabolic or signaling pathways that are present within living cells and emit a bioluminescent signal that can be detected upon exposure to target chemicals. Although relatively less specific compared to analytical methods, bioluminescent bioassays are more cost-effective, more rapid, can be scaled to higher throughput, and can be designed to report not only the presence but also the bioavailability of target substances. This chapter reviews available bacterial and eukaryotic whole-cell bioreporters for sensing organic pollutants and their applications in a variety of sample matrices.

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Section: Evaluation Of Organic Toxicant-induced Health Risks Using mentioning

confidence: 99%

Detection of Organic Compounds with Whole-Cell Bioluminescent Bioassays

Smartt

et al. 2014

Advances in Biochemical Engineering/Biotechnology

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“…Biosensors are powerful analytical devices in several areas such as medicine, food safety, wastewater treatment, and environmental analysis. − Biosensors are multiadvantage devices that besides high selectivity, sensitivity, and low cost have the potential of miniaturization for on-site monitoring . Following the IUPAC definition, a biosensor is made up of three major parts: a biological recognition element (bioreceptor, e.g.…”

Section: Introductionmentioning

confidence: 99%

Membrane-Based NEMS/MEMS Biosensors

Stapf,

Selbmann,

Joseph

et al. 2024

ACS Appl. Electron. Mater.

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Membrane-based nano/microelectromechanical system (NEMS/MEMS) biosensors offer sustainable, costeffective, ultraminiaturized and easy-to-use analytical techniques for various applications, especially in the environmental and biomedical/pharmaceutical fields. Compared to cantilever-based MEMS/NEMS biosensors, membrane-based MEMS/NEMS biosensors have higher sensitivity, especially for liquid samples, as the back of the membrane is not in contact with the analyte solution, resulting in a higher signal-to-noise ratio. This review provides deep insight into the fundamentals, membrane materials, different biosensing designs, as well as various transducers used in membrane-based MEMS/NEMS biosensors. The performance of the developed membrane-based MEMS/NEMS biosensors is critically discussed, and their trends and challenges are highlighted. Among the reported biosensors, capacitive-based surface stress biosensors and capacitive micromachined ultrasonic transducer (CMUT) biosensors are emerging as sophisticated and sensitive platforms for biosensing with the ability to detect multiple targets simultaneously. Nevertheless, challenges remain in biosensor design, parameter optimization, and selection of appropriate membrane materials. Further research is imperative to improve the capabilities of these biosensors, particularly in advancing array technologies for the simultaneous detection of multiple analytes.

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“…Therefore, a cheap, simple, and continuous monitoring methodology for a wide range of pollutants would be welcome. Biosensors offer some advantages for air toxicity analysis as they may include living organisms and therefore offer the possibility of miniaturization and portability, which then enable their use as field devices for on-site monitoring …”

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confidence: 99%

Bioluminescent Liquid Light Guide Pad Biosensor for Indoor Air Toxicity Monitoring

2015

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Indoor air pollution became a recent concern found to be oftentimes worse than outdoor air quality. We developed a tool that is cheap and simple and enables continuous monitoring of air toxicity. It is a biosensor with both a nondisposable (monitor) and disposable (calcium alginate pads with immobilized bacteria) elements. Various parameters to enhance its signal have been tested (including the effect of the pad's orientation, it's exposure to either temperature or time with the air toxicant analyte, and various concentrations thereof). Lastly, the sensor has demonstrated its ability to sense the presence of chemicals in a real, indoor environment. This is the first step in the creation of a sensitive and simple operative tool that may be used in different indoor environments.

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Biosensors for endocrine disruptors

Cited by 7 publications

References 170 publications

Detection of Organic Compounds with Whole-Cell Bioluminescent Bioassays

Detection of Organic Compounds with Whole-Cell Bioluminescent Bioassays

Membrane-Based NEMS/MEMS Biosensors

Bioluminescent Liquid Light Guide Pad Biosensor for Indoor Air Toxicity Monitoring

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