Biosensors for detection of paralytic shellfish toxins: Recognition elements and transduction technologies

Wei, Liu-Na; Luo, Lin; Wang, Bingzhi; Lei, Hongtao; Guan, Tian; Shen, Yu-Dong; Wang, Hong; Xu, Zhen-Lin

doi:10.1016/j.tifs.2023.02.012

Cited by 16 publications

(2 citation statements)

References 139 publications

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“…These toxins primarily consist of paralytic shellfish toxin, diarrheal shellfish toxin, neurotoxic shellfish toxin, and amnesic shellfish toxin. Among them, PSTs stand out as highly potent, high-risk neurotoxins that are commonly found in both freshwater and marine environments . PSTs are initially produced by dinoflagellates and cyanobacteria.…”

Section: Progress Of Nbs Against Food-borne Biotoxins and The Neutral...mentioning

confidence: 99%

“…Among them, PSTs stand out as highly potent, high-risk neurotoxins that are commonly found in both freshwater and marine environments. 116 PSTs are initially produced by dinoflagellates and cyanobacteria. When shellfish consume algae containing PSTs, they accumulate and concentrate these toxins, posing a risk to humans when consumed as seafood.…”

Section: Nbs For Animal Toxin Neutralizationmentioning

confidence: 99%

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Food-Borne Biotoxin Neutralization in Vivo by Nanobodies: Current Status and Prospects

Liu,

Liang,

Jin

et al. 2024

J. Agric. Food Chem.

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Food-borne biotoxins from microbes, plants, or animals contaminate unclean, spoiled, and rotten foods, posing significant health risks. Neutralizing such toxins is vital for human health, especially after food poisoning. Nanobodies (Nbs), a type of single-domain antibodies derived from the genetic cloning of a variable domain of heavy chain antibodies (VHHs) in camels, offer unique advantages in toxin neutralization. Their small size, high stability, and precise binding enable effective neutralization. The use of Nbs in neutralizing food-borne biotoxins offers numerous benefits, and their genetic malleability allows tailored optimization for diverse toxins. As nanotechnology continues to evolve and improve, Nbs are poised to become increasingly efficient and safer tools for toxin neutralization, playing a pivotal role in safeguarding human health and environmental safety. This review not only highlights the efficacy of these agents in neutralizing toxins but also proposes innovative solutions to address their current challenges. It lays a solid foundation for their further development in this crucial field and propels their commercial application, thereby contributing significantly to advancements in this domain.

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Section: Progress Of Nbs Against Food-borne Biotoxins and The Neutral...mentioning

confidence: 99%

Section: Nbs For Animal Toxin Neutralizationmentioning

confidence: 99%

Food-Borne Biotoxin Neutralization in Vivo by Nanobodies: Current Status and Prospects

Liu,

Liang,

Jin

et al. 2024

J. Agric. Food Chem.

Self Cite

View full text Add to dashboard Cite

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Nanozyme‐Enhanced Electrochemical Biosensors: Mechanisms and Applications

Yang,

Guo,

Wang

et al. 2023

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Nanozymes, as innovative materials, have demonstrated remarkable potential in the field of electrochemical biosensors. This article provides an overview of the mechanisms and extensive practical applications of nanozymes in electrochemical biosensors. First, the definition and characteristics of nanozymes are introduced, emphasizing their significant role in constructing efficient sensors. Subsequently, several common categories of nanozyme materials are delved into, including metal‐based, carbon‐based, metal‐organic framework, and layered double hydroxide nanostructures, discussing their applications in electrochemical biosensors. Regarding their mechanisms, two key roles of nanozymes are particularly focused in electrochemical biosensors: selective enhancement and signal amplification, which crucially support the enhancement of sensor performance. In terms of practical applications, the widespread use of nanozyme‐based electrochemical biosensors are showcased in various domains. From detecting biomolecules, pollutants, nucleic acids, proteins, to cells, providing robust means for high‐sensitivity detection. Furthermore, insights into the future development of nanozyme‐based electrochemical biosensors is provided, encompassing improvements and optimizations of nanozyme materials, innovative sensor design and integration, and the expansion of application fields through interdisciplinary collaboration. In conclusion, this article systematically presents the mechanisms and applications of nanozymes in electrochemical biosensors, offering valuable references and prospects for research and development in this field.

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