Biosensors Based on Graphene Nanomaterials

Кулакова, И. И.; Лисичкин, Г. В.

doi:10.3103/s0027131422060049

Cited by 6 publications

(4 citation statements)

References 85 publications

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“…In addition, graphene's high sensitivity and large surface area make it an excellent material for sensors. It can be used to develop highly sensitive gas sensors, biosensors for detecting diseases, and environmental sensors for monitoring pollutants [27][28][29]. Similarly, graphene's unique properties enable efficient water filtration.…”

Section: Applications Of Graphene In Various Fieldsmentioning

confidence: 99%

Review on Smart Nanocarrier Bilayer Lipid-Coated graphene@MSN Nanocomposites

Patil,

Patel

2023

Preprint

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In the contemporary era, there has been a notable surge in the systematic utilization of therapeutic drugs that exhibit stimulus-responsive drug release patterns in specific target areas. However, challenges such as premature drug release and limited biocompatibility persist. To address these issues, the application of a lipid coating on mesoporous silica nanoparticles (MSNs) has emerged as a promising strategy. This lipid coating not only enhances the stability and biocompatibility of nanocarriers but also facilitates targeted drug delivery to diseased cells while minimizing drug release throughout the body. MSNs, renowned for their unique attributes including high porosity, morphology, and controllable pore size, have been widely recognized as suitable platforms for drug/gene delivery systems. Furthermore, graphene-based nanomaterials such as graphene oxide and reduced graphene oxide have garnered significant interest in the fields of biology and biomedicine. These materials possess exceptional characteristics such as a large surface area, distinct surface properties, high biocompatibility, and pH sensitivity, making them ideal candidates for incorporating drugs, genes, photosensitizers, and other cargo to design innovative drug delivery systems. This study aims to emphasize the ongoing efforts and advancements in enhancing the capacity and versatility of nanocomposites comprising graphene MSN composites for applications in drug delivery.

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Section: Applications Of Graphene In Various Fieldsmentioning

confidence: 99%

Review on Smart Nanocarrier Bilayer Lipid-Coated graphene@MSN Nanocomposites

Patil,

Patel

2023

Preprint

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“…Graphene has been extensively studied in various optoelectronic fields, such as photodetectors [19], polarizers [20], optical modulators [21], and biosensors [22]. Moreover, the optical properties of graphene can be effectively manipulated by the external fields [23]. Graphene has the characteristics of dynamic tunability and low optical loss.…”

Section: Introductionmentioning

confidence: 99%

A high figure of merit of phonon-polariton waveguide modes with hBN/SiO 2 /graphene/hBN ribs waveguide in THz range

刘

Zhao

JIN

et al. 2023

Preprint

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The utilization of THz waveguides has enabled a variety of applications in integrated optics and communications. To effectively control THz signals on photonic chips, it is essential to design a waveguide that offers both a high figure of merit (FOM) and low loss. In this paper, we propose a THz waveguide composed of a dielectric rib and a graphene layer sandwiched between two hexagonal boron nitride (hBN) ribs on a gold layer. Numerical simulations demonstrate the existence of two type guided modes of the proposed waveguide in the second reststrahlen band (1360.0cm− 1 < ω < 1609.8cm− 1) of hBN. These modes are formed by coupling the hyperbolic phonon polariton (HPhP) of two hBN rib in the middle dielectric rib and are then modulated by a graphene layer. Interestingly, we found that four waveguide transmission parameters, including an effective length, a figure of merit, a device length and a propagation loss of the guided modes, vary with operation frequency and gate voltage. By altering geometry parameters and dielectric permittivity, the modal properties were analyzed. Simulation results demonstrate that a high FOM of 4.0×107 is achieved by optimizing waveguide size parameters. The proposed waveguide offers a promising approach for designing a tunable THz waveguide on photonic chips, which can be extended to other hyperbolic materials and 2D materials such as MnO3, silicone and germanene.

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“…Graphene, on the other hand, is a two-dimensional carbon nanomaterial whose atoms form a hexagonal crystal lattice [ 19 , 20 , 21 ]. Its large surface area provides a more extensive interface for enzyme immobilization, leading to higher sensitivity and lower detection limits [ 22 , 23 ]. Additionally, the exclusive electronic properties of graphene allow for efficient charge transfer between the electrode surface and the immobilized enzyme, resulting in improved biosensing performance [ 24 , 25 ].…”

Section: Introductionmentioning

confidence: 99%

“…Graphene, on the other hand, is a two-dimensional carbon nanomaterial whose atoms form a hexagonal crystal lattice [19][20][21]. Its large surface area provides a more extensive interface for enzyme immobilization, leading to higher sensitivity and lower detection limits [22,23]. Additionally, the exclusive electronic properties of graphene allow for efficient charge transfer between the electrode Carbon nanotubes (CNTs) are cylindrical structures made of graphene sheets presenting different characteristics such as length, diameter, and number of layers, and they are categorized into single-walled carbon nanotubes (SWCNTs) and multi-walled carbon nanotubes (MWCNTs) [13,14].…”

Section: Introductionmentioning

confidence: 99%

Structure-Function Studies of Glucose Oxidase in the Presence of Carbon Nanotubes and Bio-Graphene for the Development of Electrochemical Glucose Biosensors

Alatzoglou,

Tzianni,

Patila

et al. 2023

Nanomaterials

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In this work, we investigated the effect of multi-walled carbon nanotubes (MWCNTs) and bio-graphene (bG) on the structure and activity of glucose oxidase (GOx), as well as on the performance of the respective electrochemical glucose biosensors. Various spectroscopic techniques were applied to evaluate conformational changes in GOx molecules induced by the presence of MWCNTs and bG. The results showed that MWCNTs induced changes in the flavin adenine dinucleotide (FAD) prosthetic group of GOx, and the tryptophan residues were exposed to a more hydrophobic environment. Moreover, MWCNTs caused protein unfolding and conversion of α-helix to β-sheet structure, whereas bG did not affect the secondary and tertiary structure of GOx. The effect of the structural changes was mirrored by a decrease in the activity of GOx (7%) in the presence of MWCNTs, whereas the enzyme preserved its activity in the presence of bG. The beneficial properties of bG over MWCNTs on GOx activity were further supported by electrochemical data at two glucose biosensors based on GOx entrapped in chitosan gel in the presence of bG or MWCNTs. bG-based biosensors exhibited a 1.33-fold increased sensitivity and improved reproducibility for determining glucose over the sweat-relevant concentration range of glucose.

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Biosensors Based on Graphene Nanomaterials

Cited by 6 publications

References 85 publications

Review on Smart Nanocarrier Bilayer Lipid-Coated graphene@MSN Nanocomposites

Review on Smart Nanocarrier Bilayer Lipid-Coated graphene@MSN Nanocomposites

A high figure of merit of phonon-polariton waveguide modes with hBN/SiO 2 /graphene/hBN ribs waveguide in THz range

Structure-Function Studies of Glucose Oxidase in the Presence of Carbon Nanotubes and Bio-Graphene for the Development of Electrochemical Glucose Biosensors

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