Biosensors Based on Electropolymerized Films

Cosnier, Serge; Holzinger, Michael

doi:10.1002/9783527630592.ch10

Cited by 22 publications

(23 citation statements)

References 129 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although chemical oxidative polymerization makes use of chemical agents to perform the oxidation of the EDOT monomer, in electrochemical polymerization the oxidation is performed by an electrochemical technique, this being galvanostatic (constant current), potentiostatic (constant potential), galvanodynamic (pulsed current), or potentiodynamic (cyclic voltammetry or pulsed potential) [34]. In a typical electropolymerization experiment, a three-electrode cell configuration is employed (the counter, reference, and working electrodes) and the EDOT monomer is dissolved in an electrolyte solution.…”

Section: Electrochemical Polymerizationmentioning

confidence: 99%

Functionalization Strategies of PEDOT and PEDOT:PSS Films for Organic Bioelectronics Applications

et al. 2021

View full text Add to dashboard Cite

Organic bioelectronics involves the connection of organic semiconductors with living organisms, organs, tissues, cells, membranes, proteins, and even small molecules. In recent years, this field has received great interest due to the development of all kinds of devices architectures, enabling the detection of several relevant biomarkers, the stimulation and sensing of cells and tissues, and the recording of electrophysiological signals, among others. In this review, we discuss recent functionalization approaches for PEDOT and PEDOT:PSS films with the aim of integrating biomolecules for the fabrication of bioelectronics platforms. As the choice of the strategy is determined by the conducting polymer synthesis method, initially PEDOT and PEDOT:PSS films preparation methods are presented. Later, a wide variety of PEDOT functionalization approaches are discussed, together with bioconjugation techniques to develop efficient organic-biological interfaces. Finally, and by making use of these approaches, the fabrication of different platforms towards organic bioelectronics devices is reviewed.

show abstract

Section: Electrochemical Polymerizationmentioning

confidence: 99%

Functionalization Strategies of PEDOT and PEDOT:PSS Films for Organic Bioelectronics Applications

et al. 2021

View full text Add to dashboard Cite

show abstract

“…CPs are π conjugated polymers with an electronic structure giving them intrinsic characteristics such as electrical conductivity, which can be controlled by a doping/de-doping process, low ionization potential, high electron transfer ability and optical properties. Polypyrrole (CPPy) is one of the conducting polymers extensively applied for the design of bioanalytical sensors [11] [12] including DNA detection [13]. This is related to their electrical, electrochemical properties as well as their ability of immobilization onto micro size surface by electropolymerisation [14].…”

Section: Introductionmentioning

confidence: 99%

E-DNA biosensors of M. tuberculosis based on nanostructured polypyrrole

Khoder

Korri-Youssoufi

2020

Materials Science and Engineering: C

View full text Add to dashboard Cite

The objective of this paper is to demonstrate the potential of nanostructured polypyrrole formed by template free as platform for amperometric detection of DNA. The nanowires of polypyrrole (nw-PPy) are formed through electrochemical polymerization and chemically modified by electrochemical oxidation of ethylene diamine or dendrimers PAMAM to obtain aminated surface. The DNA probe and ferrocenyl group, as redox reporter, were covalently linked to the surface of nw-PPy. The chemical structure of nanostructured platform was characterized through SEM, FT-IR and XPS and the electrochemical properties through cyclic voltammetry and electrochemical impedance spectroscopy (EIS). We show that the properties of nw-PPy such as, hydrophilic character and large surface area have large effect on the electronic properties. Thus, the electrochemical performance is increased compared to others nanomaterials considering the obtained value of the rate of electron transfer of 18 s -1 . These properties allow enhanced DNA sensing where detection limit of 0.36 atomolar without any amplification step. The biosensor can be applied in detection of genomic DNA of Mycobacterium tuberculosis and the mutated one which present the resistance to rifampicin and large selectivity was demonstrated. We believe that nw-PPy modified with redox marker is a promising platform for electrochemical biosensors and can be applied for various diagnosis prospects.

show abstract

“…A book containing several contributions that span from the fundamental aspects of CPs, e.g., mechanism of growth and electrochemical characterization, to their recent applications in sensing, in energy storage, and as artificial muscles is available by Cosnier and Karyakin (136). Wallace and coauthors (137) compiled a concise but detailed book that describes their wide range of applications and gives a brief insight into the preparation and characterization of the most common CPs employed in the literature, i.e., polypyrrole, polyaniline, and polythiophenes.…”

Section: Introducing Conducting Polymersmentioning

confidence: 99%