Biosensors Based on Acoustic Wave Devices

Rickert, Jan; Göpel, Wolfgang; Hayward, Gordon L.; Čavić, Biljana A.; Thompson, Michael

doi:10.1002/1616-8984(199904)5:1<105::aid-seup105>3.0.co;2-j

Cited by 12 publications

(6 citation statements)

References 80 publications

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“…Amongst the various transducing systems and devices that have been engineered, 1 those based on acoustic wave physics that commonly rely on the unique piezoelectric properties of quartz, 13,14 constitute an important, yet arguably underexploited 14 technology for application in the bioanalytical field. 15 The latest addition to the family of bulk acoustic wave devices, the electromagnetic piezoelectric acoustic sensor (EMPAS), which is based on the electromagnetic excitation of higher harmonics in the piezoelectric substrate, has been developed recently in our laboratory. 16 In practice, EMPAS offers several major advantages over its predecessors, such as an electrode-free environment and the ability to conduct measurements at tunable, ultra-high frequencies (up to 1 GHz), which allows for detailed information and enhances sensitivity.…”

Section: Introductionmentioning

confidence: 99%

New oligoethylene glycol linkers for the surface modification of an ultra-high frequency acoustic wave biosensor

et al. 2010

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This work describes the application of acoustic wave technology for the real-time and label-free detection of biotin-avidin interactions. Biosensing surfaces are constructed onto unelectroded piezoelectric quartz discs as functionalizable mixed self-assembled monolayers (SAM) produced from previously unreported linker and diluent molecules. Biotinthiol can subsequently be immobilized for detection purposes in a straightforward and coupling-free manner. Specific and non-specific adsorptions of avidin are measured at ultra-high frequencies (1.06 and 0.82 GHz) with an electromagnetic piezoelectric acoustic sensor (EMPAS) using micromolar avidin-spiked buffer solutions. These biosensing surfaces, especially the oligoethylene glycol SAM-based variety, display high specificity for avidin, with moderate to excellent reproducibility. This preliminary work constitutes the first application of SAM chemistry and EMPAS technology in the bioanalytical field.

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Section: Introductionmentioning

confidence: 99%

New oligoethylene glycol linkers for the surface modification of an ultra-high frequency acoustic wave biosensor

et al. 2010

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“…Biosensors can be classified according to the nature of the biochemical converter -enzyme electrodes, immunosensors and DNA sensors [6].…”

Section: Main Partmentioning

confidence: 43%

Biosensors – basics and use

Biyasheva

Temirbekova

Omelyanchuk³

2014

INT J BIOL CHEM

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“…Acoustic Wave biosensors are mass sensors which operate with mechanical acoustic waves as their transduction mechanism. Acoustic Wave devices can be classified into three groups depending on the acoustic wave guiding process [5]: Bulk Acoustic Wave (BAW) devices, Surface Acoustic Wave (SAW) devices and Acoustic Plate Mode (APM) devices. In BAW devices the acoustic wave propagates unguided through the volume of the substrate, in SAW devices the acoustic wave propagates, guided or unguided, along a single surface of the substrate and in APM devices the waves are guided by reflection from multiple surfaces.…”

Section: Introductionmentioning

confidence: 99%

Surface Generated Acoustic Wave Biosensors for the Detection of Pathogens: A Review

Rocha-Gaso

March-Iborra

Montoya-Baides

et al. 2009

Sensors

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This review presents a deep insight into the Surface Generated Acoustic Wave (SGAW) technology for biosensing applications, based on more than 40 years of technological and scientific developments. In the last 20 years, SGAWs have been attracting the attention of the biochemical scientific community, due to the fact that some of these devices -Shear Horizontal Surface Acoustic Wave (SH-SAW), Surface Transverse Wave (STW), Love Wave (LW), Flexural Plate Wave (FPW), Shear Horizontal Acoustic Plate Mode (SH-APM) and Layered Guided Acoustic Plate Mode (LG-APM) -have demonstrated a high sensitivity in the detection of biorelevant molecules in liquid media. In addition, complementary efforts to improve the sensing films have been done during these years. All these developments have been made with the aim of achieving, in a future, a highly sensitive, low cost, small size, multi-channel, portable, reliable and commercially established SGAW biosensor. A setup with these features could significantly contribute to future developments in the health, food and environmental industries. The second purpose of this work is to describe the state-of-the-art of SGAW biosensors for the detection of pathogens, being this topic an issue of extremely importance for the human health. Finally, the review discuses the commercial availability, trends and future challenges of the SGAW biosensors for such applications.

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Biosensors Based on Acoustic Wave Devices

Cited by 12 publications

References 80 publications

New oligoethylene glycol linkers for the surface modification of an ultra-high frequency acoustic wave biosensor

New oligoethylene glycol linkers for the surface modification of an ultra-high frequency acoustic wave biosensor

Biosensors – basics and use

Surface Generated Acoustic Wave Biosensors for the Detection of Pathogens: A Review

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