Biosensors as useful tools for environmental analysis and monitoring

Rodríguez-Mozaz, Sara; Alda, María J. López de; Barceló, Damià

doi:10.1007/s00216-006-0574-3

Cited by 391 publications

(205 citation statements)

References 209 publications

Supporting

Mentioning

199

Contrasting

Unclassified

Order By: Relevance

“…Furthermore, coupling SPR to fiber optic (FO) technology triggered notable advancements in the field, by offering attractive advantages over the classical prism-based SPR platforms, such as simplicity, portability, cost-effectiveness and miniaturization [2]. FO-SPR sensors were successfully used already in a variety of applications, such as screening for bacterial infections [3], monitoring of environmental water pollution [4] or checking for specific toxins [5] and allergens [6] in food, among others. However, their performance still needs to be improved in order to match traditional prismbased SPR sensors, and consequently, to switch from laboratory proofs-of-principle to commercial products.…”

Section: Introductionmentioning

confidence: 99%

Thermal annealing of gold coated fiber optic surfaces for improved plasmonic biosensing

Antohe

Schouteden

Goos

et al. 2016

Sensors and Actuators B: Chemical

View full text Add to dashboard Cite

The morphological properties of thin gold (Au) films sputtered onto fiber optic (FO) substrates play an essential role in the overall performance of the sensing devices relying on surface plasmon resonance (SPR) effects. In this work, the influence of thermal treatments on the structural changes of the Au layer coated on the FO-SPR sensors, and consequently on their plasmonic biosensing performance, was systematically investigated. First, the sensors were exposed to different annealing temperatures for different durations and their sensitivity was evaluated by refractometric measurements in sucrose dilutions. The attained results suggested the optimal annealing conditions that were further validated using a split-plot experimental design statistical model. Room-temperature scanning tunneling microscopy (STM) imaging of the FO substrates revealed changes in the granular surface texture of the thermally treated Au films that could be linked to the observed increase in sensitivity of the treated sensors. The FO sensors, annealed under optimal conditions, were finally tested as label-free aptamer -based biosensors for the detection of Ara h 1 peanut allergen. Remarkably, the results demonstrated a superior biosensing performance of the thermally treated FO sensors, as the limit of detection (LOD) was improved with up to two orders of magnitude compared to a similar non-annealed FO-SPR sensor. This significant increase in sensitivity represents a major step forward in the facile and cost-effective preparation of FO-SPR sensors capable of label-free detection of various biomolecular targets.

show abstract

Section: Introductionmentioning

confidence: 99%

Thermal annealing of gold coated fiber optic surfaces for improved plasmonic biosensing

Antohe

Schouteden

Goos

et al. 2016

Sensors and Actuators B: Chemical

View full text Add to dashboard Cite

show abstract

“…1,2 ED can block cellular receptor sites or increase the production and/or secretion of hormones, hence interfering in the reproductive systems of living organisms. [3][4][5] Many compounds are suspected of interfering with the endocrine system, 6 including natural and synthetic estrogens (lipidsoluble steroid hormones) such as 17a-ethynylestradiol, polycyclic aromatic hydrocarbons (compounds containing two or more conjugated aromatic rings, such as benzo(a) anthracene), polychlorinated biphenyls (highly toxic chlorinated compounds), pesticides (substances such as dichlorodiphenyltrichloroethane (DDT), used to repel or eliminate pathogenic insects), and plasticisers such as bisphenol A that are used in polymeric plastics. 7 ED are conveyed to aquatic systems by various natural or anthropogenic mechanisms.…”

Section: Introductionmentioning

confidence: 99%

Characterization of the interactions between endocrine disruptors and aquatic humic substances from tropical rivers

Botero¹,

Oliveira²,

Cunha³

et al. 2011

J. Braz. Chem. Soc.

View full text Add to dashboard Cite

Interações entre substâncias húmicas aquáticas (SHA), de rios tropicais, e dois interferentes endócrinos (IE) foram estudados utilizando sistema de ultrafiltração em fluxo tangencial equipado com membrana de celulose de 1 kDa com a finalidade de separar os IE livres da fração ligada as SHA. A quantificação de 17a-etinilestradiol e bisfenol A foi realizada utilizando cromatógrafo a gás acoplado a espectrômetro de massas (GC-MS). O tempo de equilíbrio entre as SHA e IE foi de aproximadamente 30 min, e as capacidades complexantes do 17a-etinilestradiol e bisfenol A foram em torno de 18,53 e 2,07 mg g -1 de carbono orgânico total (COT), respectivamente. A maior interação das SHA ocorreu para 17a-etinilestradiol, em relação ao bisfenol A, devido a presença de hidrogênio na estrutura do 17a-etinilestradiol, que podem interagir com os grupos oxigenados presentes nas SHA. Os resultados indicam que as SHA podem influenciar fortemente no transporte e reatividade dos interferentes endócrinos presentes em sistemas aquáticos.Interactions between two endocrine disruptors (ED) and aquatic humic substances (AHS) from tropical rivers were studied using an ultrafiltration system equipped with a 1 kDa cut-off cellulose membrane to separate free ED from the fraction bound in the AHS. Quantification of 17a-ethynylestradiol and bisphenol A was performed using gas chromatography-mass spectrometry (GC-MS). The times required for establishment of equilibrium between the AHS and the ED were ca. 30 min, and complexation capacities for 17a-ethynylestradiol and bisphenol A were 18.53 and 2.07 mg g -1 TOC, respectively. The greater interaction of AHS with 17a-ethynylestradiol, compared to bisphenol A, was due to the presence of hydrogen in the structure of 17a-ethynylestradiol, which could interact with ionized oxygenated groups of the AHS. The results indicate that AHS can strongly influence the transport and reactivity of endocrine disruptors in aquatic systems.Keywords: water, pollution, endocrine disruptors, aquatic humic substances, complexation capacity IntroductionPopulation increase, the development of new products, and intensified use of terrestrial and aquatic resources in industry and agriculture have resulted in the introduction into the environment of new compounds that may cause toxicity in humans and animals. Endocrine disruptors (ED) are often found in surface waters and effluents, where they can pose health risks even at low concentrations. In 1996, the European Commission defined this class of compounds as "exogenous substances that cause adverse health effects in the intact organism, or in its descendents, resulting in alterations of endocrine functions". 1,2 ED can block cellular receptor sites or increase the production and/or secretion of hormones, hence interfering in the reproductive systems of living organisms. 3-5 Many Characterization of the Interactions between Endocrine Disruptors and Aquatic Humic Substances J. Braz. Chem. Soc. 1104 compounds are suspected of interfering with the endocrine system, 6 inclu...

show abstract

“…Such analyses only provide snapshots of the situation at the sampling site and time rather than more realistic information on spatio-temporal variations in water characteristics [2].…”

Section: Biosensor For Edcsmentioning

confidence: 99%

“…These methods involves the collection of water samples followed by laboratory-based instrumental analysis and such analyses only provide snapshots of the situation at the sampling site and time rather than more realistic information on spatio-temporal variations in water characteristics [2] One of the possibilities for a faster and timely measurement for pollutants in water, lies in the use of biosensors.…”

Section: Introductionmentioning

confidence: 99%

A biosensored spatial data infrastructure for the dynamic monitoring of the presence and the activity of endocrine disrupting chemicals in water

Vito¹

2015

Third International Conference on Advances in Bio-Informatics and Environmental Engineering - ICABEE 2015

View full text Add to dashboard Cite

Abstract-Endocrine disrupting chemicals (EDCs) are a subset of environmental contaminants that can produce adverse developmental, reproductive, neurological, and immune effects in both humans and wildlife. EDCs have been reported to have a ubiquitous presence in the environment and in particular aquatic ecosystems. Many EDCs, in fact are not completely removed with conventional wastewater treatment systems. Due to their harmfulness and ubiquity, since the 1990's a number of countries, multinational governments such as the European Union and inter-government organizations (Organization for Economic Cooperation and Development, OECD) have initiated or amended programs to integrate EDCs into current strategies to assess chemical safety. These programs has been mainly focused on regulate exposure to EDCs, neglecting the issues about monitoring. Conventional water monitoring processes involves the collection of water samples that only provide snapshots of the situation at the sampling site and time, rather than information on spatiotemporal variations in water characteristics. Biosensors indeed, -defined by IUPAC as a "self-contained integrated device that is capable of providing specific analytical information using a biological recognition element" -offer the possibility for a faster and timely measurement for pollutants in water.Biosensors can be combined with remote communication technology like GPS and GPRS, resulting in networks of distributed elements able to gather spatial and temporal information. These sensing networks can be integrated with spatial data infrastructures. Spatial data infrastructures (SDI) are a framework of technologies, policies, and institutional arrangements includes all the technologies like Geographical Information Systems (GIS), geoportals and diffuse georeferred tools that enable the sharing of geospatial information on a national, regional or global level. SDI can be useful for water monitoring because can handle data and models providing spatial and temporal information on pollutant distribution and toxicity.This work proposes a main framework of and SDI for monitoring the dynamic activity of endocrine disrupting chemicals in water. The proposed SDI is based on multiple remote sensing stations equipped by a set of impedentiometric immunobiosensors coated with ER-α receptor on an ArduinoMEGA® microcontroller-board.The remote sensings are designed to gather spatial and temporal information on the type and the concentration of different EDCs compound in the sampled water.The remote sensing stations are also fitted to communicate the measured data by GPS to a central server-side, thanks to the ArduinoGSMShield®. On the server side a QSAR model is installed to estimate EDCs activity, on the basis of 2 datasets on On this view, the proposed SDI represents a useful tool to support decision-makers on regulatory policies that are inclusive of monitoring strategies.

show abstract

Biosensors as useful tools for environmental analysis and monitoring

Cited by 391 publications

References 209 publications

Thermal annealing of gold coated fiber optic surfaces for improved plasmonic biosensing

Thermal annealing of gold coated fiber optic surfaces for improved plasmonic biosensing

Characterization of the interactions between endocrine disruptors and aquatic humic substances from tropical rivers

A biosensored spatial data infrastructure for the dynamic monitoring of the presence and the activity of endocrine disrupting chemicals in water

Contact Info

Product

Resources

About