Biosensors and chemosensors based on the optical responses of polydiacetylenes

Abstract

Polydiacetylenes (PDAs), a family of conjugated polymers, have very unique electrical and optical properties. Upon environmental stimulation, such as by viruses, proteins, DNAs, metal ions, organic molecules etc., the blue PDAs can undergo a colorimetric transition from blue to red, which is accompanied by a fluorescence enhancement. Since the first report on polymerized diacetylene molecules as sensors of influenza virus, the development of efficient sensory systems based on PDAs continues to be of great interest. This tutorial review highlights the recent advances in bio- and chemo-sensors derived from polydiacetylenes.

Ultrafast and reversible thermochromism of a conjugated polymer material based on the assembly of peptide amphiphiles

“…2,3 The chromatic transition of PDA can be directly detected by the naked eye, enabling a broad spectrum of optoelectronic and sensing applications. [4][5][6][7][8][9] However, the available PDA materials oen suffer from a slow response time (tens of seconds to minutes), low reversibility (tens of cycles or even irreversible), a narrow working temperature range (less than 90 C without the introduction of inorganic components) and poor mechanical properties, mainly due to the relatively low structural regularity and strength of molecular interactions.…”

Sequentially Programmable and Cellularly Selective Assembly of Fluorescent Polymerized Vesicles for Monitoring Cell Apoptosis

“…The building precursor diacetylene‐appended choline (DC) forms the micellar assembly in the 20 × 10 −3 m 4‐(2‐hydroxyethyl)piperazine‐1‐erhanesulfonic acid (HEPES) buffer (pH = 7.4, 150 × 10 −3 m KCl) with a critical micelle concentration value of 14 µm (Figure S4, Supporting Information). The hydrolyzed product diacetylene acid (DA) has been well reported to form vesicular aggregation in aqueous solution 29, 30, 31. According to the calculation of critical packing parameter (CPP),32 DA with a CPP value of 0.94 prefers to form spherical vesicle while DC with a CPP value of 0.33 prefers to form spherical (or cylindrical) micelle 33.…”

“…The blue polydiacetylene is susceptible to a wide range of external stimuli (temperature, pressure, light, etc. ),38, 39, 40 leading to chromic changes 29, 30, 41, 42. The color of PDA changes from blue to carmine red when heated at 70 °C.…”

A highly selective and sensitive ratiometric fluorescent probe for pH measurement based on fluorescence resonance energy transfer

“…Fluorescent sensors are regarded as efficient alternative manner to sense certain chemical stimuli based on fluorescence variation. Therefore, more and more fluorescent probes have been developed to construct highly sensitive and selective sensors for the detection of cationic and anionic in recent years [18][19][20] .…”