Biosensor platform for transcription factor DNA binding activity detection

A novel dinuclear iridium(III) complex as a G-quadruplex-selective probe for the luminescent switch-on detection of transcription factor HIF-1α

“…Transcription factors are pivotal to cellular development and specialization in living organisms because of their vital role in regulating the transcription of genetic information 1 2 . However, the suppression or aberrant activity of transcription factors can cause various diseases, including abnormal hormone responses, developmental disorders, inflammation and cancer 3 4 . Consequently, the facile and sensitive detection of transcription factor activity can aid the prevention or treatment of human diseases.…”