Biosensor based on 3D graphene-supported Fe3O4 quantum dots as biomimetic enzyme for in situ detection of H2O2 released from living cells

Zhao, Yuechao; Huo, Danqun; Bao, Jing; Yang, Mei; Chen, Mei; Hou, Jingzhou; Fa, Huanbao; Hou, Changjun

doi:10.1016/j.snb.2017.01.029

Cited by 77 publications

(23 citation statements)

References 44 publications

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“…Finally, it can lead to different kinds of cancer, aging, cardiovascular dysfunctions, and Alzheimer’s and Parkinson’s diseases. Therefore, in situ measuring and monitoring the real-time concentration of H 2 O 2 by a simple, low-cost, and ultra-sensitive nanosystem from living organisms is very important 3 , 4 .…”

Section: Introductionmentioning

confidence: 99%

Bio-multifunctional noncovalent porphyrin functionalized carbon-based nanocomposite

Rabiee

Bagherzadeh

Ghadiri

et al. 2021

Sci Rep

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Herein, in a one-pot method, the reduced graphene oxide layers with the assistance of multiwalled carbon nanotubes were decorated to provide a suitable space for the in situ growth of CoNi2S4, and the porphyrins were incorporated into the layers as well to increase the sensitivity of the prepared nanostructure. The prepared nanocomposite can establish π–π interactions between the genetic material and on the surface of porphyrin rings. Also, hydrogen bonds between genetic domains and the porphyrin’ nitrogen and the surface hydroxyl groups are probable. Furthermore, the potential donor–acceptor relationship between the d7 transition metal, cobalt, and the genetic material provides a suitable way to increase the interaction and gene loading , and transfections. The reason for this phenomenon was optimized to increase the EGFP by up to 17.9%. Furthermore, the sensing ability of the nanocomposite towards H2O2 was investigated. In this regard, the limit of detection of the H2O2 obtained 10 µM. Also, the in situ biosensing ability in the HEK-293 and PC12 cell lines was evaluated by the addition of PMA. The nanocomposite showed the ability to detect the released H2O2 after adding the minimum amount of 120 ng/mL of the PMA.

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Section: Introductionmentioning

confidence: 99%

Bio-multifunctional noncovalent porphyrin functionalized carbon-based nanocomposite

Rabiee

Bagherzadeh

Ghadiri

et al. 2021

Sci Rep

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show abstract

“…stated a synthetic approach for preparing sulfur‐doped CDs which shown catalytic degradation of tetracycline antibiotic and destruction of Escherichia coli (Gram‐negative bacterium) in derivative wastewater system using the ultrasonic method for its preparation. Furthermore, the modified carbon dots with unique structure improve the photocatalysis by augmenting electron transfer and charge separation [118] …”

Section: Applications Of Carbon Dotsmentioning

confidence: 99%

“…However, because of low concentration, high reactivity, and large diffusivity of hydrogen peroxide, its accurate and selective in situ recognition in living cells is still a gigantic challenge. For in situ detection of H 2 O 2 , 3D graphene supported Fe 3 O 4 CDs‐based biosensers are usedasa biomimeticenzyme [118] …”

Section: Applications Of Carbon Dotsmentioning

confidence: 99%

Recent Development in Synthesis of Carbon Dots from Natural Resources and Their Applications in Biomedicine and Multi‐Sensing Platform

et al. 2021

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Carbon has always found a spotlight in human life either in the form of graphite, diamonds, activated charcoal, carbon nanotubes, or carbon dots (CDs). Carbon quantum dots (CQDs) or CDs became the centre of attraction because of their potential applications in biomedical field such as bio‐imaging, drug nanocarriers, gene therapeutics, photosensitizing agents, theranostics and provides other multifunctional diagnostic platforms. There are numerous advantages of CDs due to their biocompatibility, reduced toxicity, water‐solubility, ease of scale‐up, and, most notably their fluorescence properties contrary to other carbon nanostructures. In last few years, significant efforts have been put by various research teams to synthesize and develop nanostructured materials possessing specific functional properties and characteristics. This work focus on the recent developments in the synthetic approaches applied for CDs using environment‐friendly sources. This review also highlights the mechanistic aspects, applications of CDs in biomedicine and a multi‐sensing platform along with challenges and future perspectives of this promising field. The authors believe that this review will help audible researchers to select a suitable environment‐friendly approach for the synthesis of CDs from green sources with required functions and properties. It will also guide researchers to develop a more convenient, efficient, and environment‐friendly method for the synthesis of new tunable carbon dots.

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“…Few oxides (e.g. CeO 2 [23] and Fe 3 O 4 [21,42]), Fe-containing macrocycles (e.g. Fe(III) meso-tetra (4-carboxyphenyl) porphyrin [26], and Fe(II) phthalocyanine [45]), and biomacromolecules (e.g.…”

Section: Electrochemical Sensors Built With Graphene-based Materialsmentioning

confidence: 99%

2D materials in electrochemical sensors for in vitro or in vivo use

et al. 2020

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Individual cells and cell populations are at the present time investigated with a myriad of analytical tools. While most of them are commercially available, some of these analytical tools are just emerging from research laboratories and are in the developmental phase. Electrochemical sensors which allow the monitoring of low molecular weight compounds released (and / or uptaken) by cells are among these emerging tools. Such sensors are increasingly built using 2D materials (e.g. graphene-based materials, transition metal dichalcogenides, etc.) with the aim of conferring better analytical performances to these devices. The present work critically reviews studies published during the last 10 years describing electrochemical sensors made with 2D materials and exploited to monitor small compounds (e.g. H 2 O 2 , •NO, glucose, etc.) in living biological systems. It also discusses the very few 2D material-based electrochemical sensors which are wearable or usable in vivo. Finally, the present work includes a specific section about 2D material biocompatibility, a fundamental requirement for 2D material-based sensor applications in vitro and in vivo. As such, the review provides a critical view on the state of the art of electrochemical sensors made with 2D materials and used at cellular level and it evaluates the possibility that such sensors will be used on / in the human body on a wider scale.

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Biosensor based on 3D graphene-supported Fe3O4 quantum dots as biomimetic enzyme for in situ detection of H2O2 released from living cells

Cited by 77 publications

References 44 publications

Bio-multifunctional noncovalent porphyrin functionalized carbon-based nanocomposite

Bio-multifunctional noncovalent porphyrin functionalized carbon-based nanocomposite

Recent Development in Synthesis of Carbon Dots from Natural Resources and Their Applications in Biomedicine and Multi‐Sensing Platform

2D materials in electrochemical sensors for in vitro or in vivo use

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