Biosensing platform on ferrite magnetic nanoparticles: Synthesis, functionalization, mechanism and applications

Cancer is the second cause of death worldwide, whose treatment often involves chemotherapy. In a conventional therapy, drug is transported (and usually absorbed) across biological membranes through diffusion and systemic transport. The pathway that medicine must travel before reaching the desired location, can bring adverse or unwanted effects, which are mainly the result of: low bioavailability, low solubility and toxicity. To avoiding risks, nanoparticles coated with the drug could be used as a therapeutic substance to selectively reach an area of interest to act without affecting non-target cells, organs, or tissues (drug delivery). Here, the goal is to enhance the concentration of the chemotherapeutic drug in the disease parts of the body. Among all nanostructured systems, ferrites attract worldwide attention in drug delivery applications. It is due to their versatile magnetic and physicochemical properties. Here, it is reviewed and analyzed recent advances in synthesis, morphology, size, magnetic properties, functionalization with a focus in drug delivery applications of nanoferrites.

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“…Tripathy et al [14] reported a comparison among the different techniques for ferrite nanoparticles obtention.…”

Section: Figurementioning

confidence: 99%

Nanoferrites-Based Drug Delivery Systems as Adjuvant Therapy for Cancer Treatments. Current Challenges and Future Perspectives

Osorio¹,

Herrera²,

Londoño³

et al. 2021

Ferrites - Synthesis and Applications

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“…22 More significantly, the salient potential of the conductive polymers in anticorrosive coatings, 23 energy storage, electrochemical supercapacitors, 24 sensing, 25 environmental remediation, 26 antimicrobial properties, water treatment, 27 and energy recovery fields has boosted their significance. In recent years, researchers have had a great interest in spinel ferrite nanoparticles due to their extensive applications in gas sensing, 28 inductors, 29 biosensing, 30 sequestration of lanthanides and actinides from aqueous solutions, 31 telecommunications, 32 and hyperthermia applications in cancer therapy. 33 Magnetic nanoparticles such as Fe 3 O 4 , 34−36 ZnFe 2 O 4 , 36,37 NiFe 2 O 4 , 38−40 and (NiZn)Fe 2 O 4 41,42 are wellknown traditional microwave absorbers, proven to have significant magnetic loss properties.…”

Section: ■ Introductionmentioning

confidence: 99%

“…In recent years, researchers have had a great interest in spinel ferrite nanoparticles due to their extensive applications in gas sensing, inductors, biosensing, sequestration of lanthanides and actinides from aqueous solutions, telecommunications, and hyperthermia applications in cancer therapy . Magnetic nanoparticles such as Fe 3 O 4 , − ZnFe 2 O 4 , , NiFe 2 O 4 , − and (NiZn)Fe 2 O 4 , are well-known traditional microwave absorbers, proven to have significant magnetic loss properties.…”

Section: Introductionmentioning

confidence: 99%

Facile Synthesis of Polyindole/Ni_1–xZn_xFe₂O₄(x= 0, 0.5, 1) Nanocomposites and Their Enhanced Microwave Absorption and Shielding Properties

et al. 2022

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The present work reports the fabrication of polyindole (PIN)/Ni 1– x Zn x Fe 2 O 4 ( x = 0, 0.5, 1) nanocomposites as efficient electromagnetic wave absorbers by a facile in situ emulsion polymerization method for the first time. The samples were characterized through Fourier transform infrared spectroscopy, UV–vis spectroscopy, X-ray diffraction, thermogravimetric analysis, scanning electron microscopy, high-resolution transmission electron microscopy, and vibrating sample magnetometry. The resulting polyindole/Ni 1– x Zn x Fe 2 O 4 ( x = 0, 0.5, 1) nanocomposites offer better synergism among the Ni 1– x Zn x Fe 2 O 4 nanoparticles and PIN matrix, which significantly improved impedance matching. The best impedance matching of Ni 1– x Zn x Fe 2 O 4 /polyindole ( x = 0, 0.5, 1) nanocomposites was sought out, and the minimum reflection loss of the composites can reach up to −33 dB. The magnetic behavior, complex permittivity, permeability, and microwave absorption properties of polyindole/Ni 1– x Zn x Fe 2 O 4 ( x = 0, 0.5, 1) nanocomposites have also been studied. The microwave absorbing characteristics of these composites were investigated in the 8–12 GHz range (X band) and explained based on eddy current, natural and exchange resonance, and dielectric relaxation processes. These results provided a new idea to upgrade the performance of conventional microwave-absorbing materials based on polyindole in the future.

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“…They also discussed about the advantages of using MPs, for instance low cost, high surface area, easy storage, and signal detection [11]. Another study investigated the ferrite magnetic nanoparticles functionalization and application in biosensors, where the authors have studied the key factors for sensitivity, selectivity, current challenges along with future trend [12]. Wang et al also explored recent advances and applications of magnetic nanobead based biosensors, their structures and specifications, besides future trends for biosensors [13].…”

Section: Introductionmentioning

confidence: 99%

MHz range frequency based sensor for Magnetic Particle Detection

CHAYCHIAN¹,

Dayyani²,

Balachandran³

et al. 2022

Preprint

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<p>Design of rapid technique for magnetic particles detection based on inductive sensing is described in this paper. A fabricated 3D coil, oscillating at few MHz range frequencies, is used as a sensing element with its associated electronics for inductance measurements. Phase locked loop is used for sensor stability and accuracy in the detection system. The induced magnetic field, due to the presence of magnetic particles on the coil, alter the coil inductance and accordingly the output frequency signal. Different concentration and number of magnetic beads (µm to nm sizes) were tested with the sensor while oscillating at two different resonance frequencies and the results were compared together. </p>

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Biosensing platform on ferrite magnetic nanoparticles: Synthesis, functionalization, mechanism and applications

Cited by 52 publications

References 526 publications

Nanoferrites-Based Drug Delivery Systems as Adjuvant Therapy for Cancer Treatments. Current Challenges and Future Perspectives

Nanoferrites-Based Drug Delivery Systems as Adjuvant Therapy for Cancer Treatments. Current Challenges and Future Perspectives

Facile Synthesis of Polyindole/Ni_1–xZn_xFe₂O₄(x= 0, 0.5, 1) Nanocomposites and Their Enhanced Microwave Absorption and Shielding Properties

MHz range frequency based sensor for Magnetic Particle Detection

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Biosensing platform on ferrite magnetic nanoparticles: Synthesis, functionalization, mechanism and applications

Cited by 52 publications

References 526 publications

Nanoferrites-Based Drug Delivery Systems as Adjuvant Therapy for Cancer Treatments. Current Challenges and Future Perspectives

Nanoferrites-Based Drug Delivery Systems as Adjuvant Therapy for Cancer Treatments. Current Challenges and Future Perspectives

Facile Synthesis of Polyindole/Ni1–xZnxFe2O4(x= 0, 0.5, 1) Nanocomposites and Their Enhanced Microwave Absorption and Shielding Properties

MHz range frequency based sensor for Magnetic Particle Detection

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Product

Resources

About

Facile Synthesis of Polyindole/Ni_1–xZn_xFe₂O₄(x= 0, 0.5, 1) Nanocomposites and Their Enhanced Microwave Absorption and Shielding Properties