Biosensing platform for the detection of uric acid based on graphene quantum dots and G-quadruplex/hemin DNAzyme

Cai, Nan; Tan, Linlin; Li, Yan; Xia, Tingting; Hu, Tianyu; Su, Xingguang

doi:10.1016/j.aca.2017.01.067

Cited by 48 publications

(15 citation statements)

References 42 publications

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“…The detection limit of the UA biosensor was estimated to be about 0.01 μM (S/N = 3). It was obvious that MIT/TiO 2 nanoparticle/QCM electrode exhibited superior linear range and lower detection limit to UA molecules while comparing with the previously reported UA sensors (Table ), which guaranteed its possible applications.…”

Section: Resultsmentioning

confidence: 57%

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Modification of nanocrystalline TiO₂ coatings with molecularly imprinted TiO₂ for uric acid recognition

Zhang¹,

Xiao

Qin

et al. 2018

J of Molecular Recognition

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Combining the surface modification and molecular imprinting technique, a novel piezoelectric sensing platform with excellent molecular recognition capability was established for the detection of uric acid (UA) based on the immobilization of TiO2 nanoparticles onto quartz crystal microbalance (QCM) electrode and modification of molecularly imprinted TiO2 (MIT) layer on TiO2 nanoparticles. The performance of the fabricated biosensor was evaluated, and the results indicated that the biosensor exhibited high sensitivity in UA detection, with a linear range from 0.04 to 45 μM and a limit of detection of 0.01 μM. Moreover, the biosensor presented high selectivity towards UA in comparison with other interferents. The analytical application of the UA biosensor confirmed the feasibility of UA detection in urine sample.

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Section: Resultsmentioning

confidence: 57%

“…Over the low concentration range (0.04-45 μM), good linearity was obtained, as illustrated in Figure 6B. (Table 1), [7][8][9]11,12,34,35 which guaranteed its possible applications.…”

Section: Biosensing Performancementioning

confidence: 73%

Modification of nanocrystalline TiO₂ coatings with molecularly imprinted TiO₂ for uric acid recognition

Zhang¹,

Xiao

Qin

et al. 2018

J of Molecular Recognition

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“…In 2018, Sahub et al designed an enzyme-based sensor for the detection of a pesticide, dichlorvos (i.e., an organophosphate) as represented in Figure 5A [143]. This strategy involved the production of H2O2 from the enzymatic reaction of acetylcholinesterase (AChE) and choline oxidase (CHOx), which could react with GQDs to generate a "turn-off" photoluminescence of GQDs and could be restored at 467 nm in the presence of dichlorvos.…”

Section: Photoluminescence-based Gqd-sensorsmentioning

confidence: 99%

Applications of Graphene Quantum Dots in Biomedical Sensors

Mansuriya

Altıntaş

2020

Sensors

164

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Due to the proliferative cancer rates, cardiovascular diseases, neurodegenerative disorders, autoimmune diseases and a plethora of infections across the globe, it is essential to introduce strategies that can rapidly and specifically detect the ultralow concentrations of relevant biomarkers, pathogens, toxins and pharmaceuticals in biological matrices. Considering these pathophysiologies, various research works have become necessary to fabricate biosensors for their early diagnosis and treatment, using nanomaterials like quantum dots (QDs). These nanomaterials effectively ameliorate the sensor performance with respect to their reproducibility, selectivity as well as sensitivity. In particular, graphene quantum dots (GQDs), which are ideally graphene fragments of nanometer size, constitute discrete features such as acting as attractive fluorophores and excellent electro-catalysts owing to their photo-stability, water-solubility, biocompatibility, non-toxicity and lucrativeness that make them favorable candidates for a wide range of novel biomedical applications. Herein, we reviewed about 300 biomedical studies reported over the last five years which entail the state of art as well as some pioneering ideas with respect to the prominent role of GQDs, especially in the development of optical, electrochemical and photoelectrochemical biosensors. Additionally, we outline the ideal properties of GQDs, their eclectic methods of synthesis, and the general principle behind several biosensing techniques.

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“…Excessive levels could be caused by leukemia or cardiovascular diseases, and lower UA levels might be related to multiple sclerosis. 2 Hence, the development of novel methods for reliable quantication of UA in biological uids is signicant of the diseases treatment.…”

Section: Introductionmentioning

confidence: 99%

“…Up to now, various analytical methods and procedures for the determination of UA have been developed including high performance liquid chromatography, 3 capillary electrophoresis, 4 chemiluminescence, 5 colorimetry, 6 amperometric detection 7 and biosensing. 2,8 In general, chromatographic methods are time-consuming with high implementation costs, oentimes with the need for preconcentration and derivatization steps. Therefore, sensitive, simple, fast, efficient and non-toxic methods for the quantication of UA in biological uids and environmental samples are still needed.…”

Section: Introductionmentioning

confidence: 99%

The doping level of boron-doped diamond electrodes affects the voltammetric sensing of uric acid

et al. 2018

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Biosensing platform for the detection of uric acid based on graphene quantum dots and G-quadruplex/hemin DNAzyme

Cited by 48 publications

References 42 publications

Modification of nanocrystalline TiO₂ coatings with molecularly imprinted TiO₂ for uric acid recognition

Modification of nanocrystalline TiO₂ coatings with molecularly imprinted TiO₂ for uric acid recognition

Applications of Graphene Quantum Dots in Biomedical Sensors

The doping level of boron-doped diamond electrodes affects the voltammetric sensing of uric acid

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Biosensing platform for the detection of uric acid based on graphene quantum dots and G-quadruplex/hemin DNAzyme

Cited by 48 publications

References 42 publications

Modification of nanocrystalline TiO2 coatings with molecularly imprinted TiO2 for uric acid recognition

Modification of nanocrystalline TiO2 coatings with molecularly imprinted TiO2 for uric acid recognition

Applications of Graphene Quantum Dots in Biomedical Sensors

The doping level of boron-doped diamond electrodes affects the voltammetric sensing of uric acid

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Product

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Modification of nanocrystalline TiO₂ coatings with molecularly imprinted TiO₂ for uric acid recognition

Modification of nanocrystalline TiO₂ coatings with molecularly imprinted TiO₂ for uric acid recognition