Bioscope: New Sensor for Remote Evaluation of The Physiological State of Biological Systems

Sargsyan, R. Sh.; Gevorkyan, A. A.; Karamyan, G. G.; Vardanyan, Vahe; Manukyan, A. M.; Nikogosyan, A. H.

doi:10.1007/978-94-007-0044-4_24

Cited by 4 publications

(2 citation statements)

References 3 publications

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“…In the next series of experiments, to assess the general physiological state of the body, the integrative signal of the body was recorded using the "Bioscope" hardware complex [9,10].…”

Section: Methodsmentioning

confidence: 99%

The Reaction of Various Functional Systems of the Body in the Dynamics of Oxygen Deficiency

Karapetyan¹,

Adamyan²,

Sahakyan³

2022

AJBIO

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The paper presents a comparative analysis of data on the effect of moderate and acute hypoxia on the functional state of systems at various levels of organization -molecular (amide groups of brain proteins), cellular (background electrical activity of neurons), systemic (electroencephalogram -EEG, electrocardiogram (ECG) and organismic (integrative signal of the body). Changes in electrographic parameters have an adaptive meaning for the body and are of a phase nature: in moderate hypoxia (4500-5000 m) the indicators are activated, and at acute hypoxia (7500 -8000 m) -are depressed. 15-30 minutes after exposure to hypoxia at normal atmospheric pressure, the values of almost all indicators are back to normal. It is shown, that a prolonged aftereffect of acute hypoxia is observed at the organism molecular level. Under oxygen deficiency, the number of amide groups of brain proteins increases. After the hypoxic factor, this violation persists for a day. The data of the influence of hypoxia on animals, lead to the conclusion, that the functional systems of different levels of organization react ambiguously to the impact of increasing oxygen deficiency. However, in the dynamics of hypoxia in the values of the integrative signal recorded by a non-invasive method from the body surface, phase changes are not observed, on the contrary, the shifts are unidirectional. Certain deviations of the indicators of the integrative signal in the phase of moderate hypoxia increase during acute hypoxia and continue for several hours. We conclude that the remote "Bioscope" signal being integral in nature, is not the sum of individual electrographic indicators of various functional systems and has a high sensitivity and specificity to the change of physiological state of animal.

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“…In the next series of experiments, to assess the general physiological state of the body, the integrative signal of the body was recorded using the "Bioscope" hardware complex [9,10].…”

Section: Methodsmentioning

confidence: 99%

The Reaction of Various Functional Systems of the Body in the Dynamics of Oxygen Deficiency

Karapetyan¹,

Adamyan²,

Sahakyan³

2022

AJBIO

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“…The foregoing makes it relevant to search for new and more sensitive instrumental approaches to the formation of oncological formations. In this regard, the "Bioscope" hardware complex developed in Armenia is of particular interest [2] [3].…”

Section: Introductionmentioning

confidence: 99%

Non-Invasive Approach to Early Diagnosis of the Formation of Oncological Neoplasms

Sargsyan¹,

Karamyan²,

Simonyan³

et al. 2023

JCT

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The currently developed instrumental approaches for detecting pathological changes in the body have a number of disadvantages. The most important of them is that the equipment is sensitive to the detection of diseases only from a certain threshold level of destructive changes in the body. The present article discusses the possibility of using the new instrumental complex "Bioscope" for early and non-invasive diagnosis of the beginning of the formation of ontological neoplasm's in the body.

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Non-invasive assessment of the effective dose of lamotrigine and topiramate for the treatment of epileptiform states in rats

Paronikyan

Sargsyan²,

Avagyan

et al. 2019

Èpilepsiâ paroksizmalʹnye sostoâ.

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Цельоценить возможность использования аппаратного комплекса «Биоскоп» для определения оптимальных доз ламотриджина и топирамата для купирования эпилептиформных состояний. Материалы и методы. На белых крысах проведены пять серий экспериментов с использованием различных доз противосудорожных препаратов ламотриджина и топирамата. В каждой серии экспериментов вначале исследовалось интегративное состояние животных в норме, затем после введения противосудорожного препарата и в последующем после введения коразола на фоне его действия. Результаты. Показана чувствительность сигналов аппаратного комплекса «Биоскоп» к введению различных доз противосудорожных препаратов. Низкие дозы препарата не влияют на интегративные показатели состояния животных. С увеличением дозы препарата показатели интегративного состояния животных начинают меняться. При этом показано, что в зависимости от степени повышения дозы противосудорожного препарата после введения коразола интегративные показатели либо возвращаются к контрольным значениям, либо вообще не меняются. Заключение. Показана возможность использования аппаратного комплекса «Биоскоп» для неинвазивной оценки эффективной дозы противосудорожных препаратов ламотриджина и топирамата для купирования эпилептиформных состояний организма крыс. Ключевые слова Ламотриджин, топирамат, коразол, аппаратный комплекс «Биоскоп», эпилептиформные состояния.

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Bioscope: New Sensor for Remote Evaluation of The Physiological State of Biological Systems

Cited by 4 publications

References 3 publications

The Reaction of Various Functional Systems of the Body in the Dynamics of Oxygen Deficiency

The Reaction of Various Functional Systems of the Body in the Dynamics of Oxygen Deficiency

Non-Invasive Approach to Early Diagnosis of the Formation of Oncological Neoplasms

Non-invasive assessment of the effective dose of lamotrigine and topiramate for the treatment of epileptiform states in rats

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