Biosafety: future priorities for research in health care

Doblhoff-Dier, O.; Collins, Caitlin

doi:10.1016/s0168-1656(00)00362-x

Cited by 9 publications

(10 citation statements)

References 24 publications

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“…Therefore, the TLR4 transgene not only improves the disease resistance of the transgenic ewe [33,35] but also ensures normal reproductive performance. The interactions of endogenous and exogenous genes might cause unexpected epigenetic modifications in DNA [1], as frequently reported in studies of mice [16]. Thus, transgenic technology may change the stable equilibrium state of the genome and cause unpredictable effects, including abnormal DNA methylation patterns, via unknown mechanisms [10].…”

Section: Discussionmentioning

confidence: 96%

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Effects of the TLR4 transgene on reproductive traits and DNA methylation pattern of oocytes in ewes

Fang¹,

Fu²,

Liu³

et al. 2014

Front. Agr. Sci. Eng.

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This study was conducted to systematically assess the reproductive performance of transgenic TLR4 ewes. In the TLR4 transgenic founders (F 0) and their positive offspring (F 1), hematological and reproductive parameters and the global DNA methylation level in oocytes at various stages were analyzed. The values of the physiological and biochemical parameters determined from the blood samples did not differ significantly between the transgenic and wild-type ewes. Moreover, the transgenic ewes showed reproductive traits similar to the wildtype ewes. These traits included characteristics of puberty, the estrus cycle, estrus duration, gestation, the pregnancy rate and the superovulation response. Additionally, no significant differences were found between transgenic and wild-type ewes in the DNA methylation level of the oocytes at various stages. In summary, the preliminary evidence presented in this paper demonstrates that the presence of the TLR4 transgene did not affect the reproductive performance in sheep.

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Section: Discussionmentioning

confidence: 96%

“…With the rapid development of transgenic technology, the number of transgenic animals has increased dramatically and has continued to grow in recent years [1]. The first established transgenic method used in livestock was the microinjection of exogenous DNA into the pronucleus of the zygote [2].…”

Section: Introductionmentioning

confidence: 99%

Effects of the TLR4 transgene on reproductive traits and DNA methylation pattern of oocytes in ewes

Fang¹,

Fu²,

Liu³

et al. 2014

Front. Agr. Sci. Eng.

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“…The biological safety cabinet is the principal device used to provide containment of aerosols generated by many infectious procedures. Regarding bio safety and bio security in biomedical laboratories, there is great concern about vaccines, diagnostic tools, or therapeutic agents, some of which are made by genetic engineering methods [5].…”

Section: Reviewmentioning

confidence: 99%

An Overview: Laboratory Safety and work Practices in Infectious Disease Research

Jadhav¹

2018

J HIV Clin Sci Res

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“…In the following we give the works most related to our interest area. Doblhoff-Dier and Collins (2001) state that research in the era of, e.g. epidemiology, immunology, development of new vaccines, diagnostic tools and therapeutics should be a top priority for every national and international research program.…”

Section: Health Researchmentioning

confidence: 99%

Fuzzy Multicriteria Evaluation of Health Research Investments

Kahraman

Suder

Kaya

2014

Technological and Economic Development of Economy

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Health research and investments are expensive, and its explicit social, health and economic impacts are hard to define. There are many challenges and assumptions in defining specific returns on investment in health research. In the literature, there is no common approach to evaluate health research impacts. Single criterion methods are generally used with validated indicators to track overall outcomes or outcomes in a specific health research area. These methods have the ability of considering only one criterion at a time, which is usually the cost of the investment. A multicriteria method is proposed for taking care of many conflicting criteria of health research investments. The difficulty of measuring intangible criteria is captured by the fuzzy set theory. Fuzzy analytic hierarchy process (AHP) is used for the selection among four possible health research investment alternatives. A sensitivity analysis is made for the changes in the values of various parameters.

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Biosafety: future priorities for research in health care

Cited by 9 publications

References 24 publications

Effects of the TLR4 transgene on reproductive traits and DNA methylation pattern of oocytes in ewes

Effects of the TLR4 transgene on reproductive traits and DNA methylation pattern of oocytes in ewes

An Overview: Laboratory Safety and work Practices in Infectious Disease Research

Fuzzy Multicriteria Evaluation of Health Research Investments

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