Biosafety evaluation of two Beauveria bassiana products on female albino rats using acute oral test

Ali, Sahar S.; El-Saadany, H.M.; Kotb, Gamila A.M.; Elshaer, Nashwa; Melebary, Sahar J.; Soliman, Soliman M.; Farag, Ahmed

doi:10.1016/j.sjbs.2022.103293

Cited by 3 publications

(4 citation statements)

References 64 publications

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“…We noted when toxicological symptoms started to appear and how long they lasted in the treated animals. For 21 days, the rats that made it through were observed every day (more details Ali et al 2022 andFarag, et al, 2022). The acute oral LD50 values were then determined.…”

Section: Determination Of Oral Ld50mentioning

confidence: 99%

“…Also, some scientist studied the biosafety of Beauveria bassiana (AUMC 9896) as entomopathogenic fungi (EPF) on female and male rats. They reported that the acute oral LD50 more than 5000 mg/ kg bw and > 1.1 x 10 10 conidia/kg bw with metabolic crude (MC) and formulation (2.5% WP) products respectively at female and male rats and there were no evidence of death or toxic symptoms in all treated animals (Ali et al 2022 andFarag, et al, 2022).…”

Section: Acute Oral Ld50 Studymentioning

confidence: 99%

“…There are several studies suggest that M. anisopliae is an effective agent against Spodoptera littoralis and Onion Thrips (Thrips tabaci) and should be applied in integrated pest management (IPM) as environmentally friendly alternative (Zhang et al, 2021;El-Saadany et al 2022). On the other hand, there are little recent studies on determination of biosafety and toxicity of entomopathogenic fungi on mammals and environmental systems such as Ali et al 2022;and Farag, et al, 2022, so, it is important to continue evaluating the safety of M. anisopliae and its effects on different parameters to ensure its safe use in pest control. The purpose of this study is to determine orally LD50 and biosafety of M. anisopliae (AUMC 5130) local strain as metabolic crude (MaC) and formulation (MaF) in rats, both male and female.…”

Section: Introductionmentioning

confidence: 99%

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Hematological and Biochemical Alterations Induced by Two Products from Metarhizium anisopliae after Oral Administration in Male and Female Albino Rats

Ahmed,

El- Saadany,

Kotb

et al. 2023

Journal of Plant Protection and Pathology

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Background: Humans and ecosystems are being harmed by the accumulation of synthetic pesticides in the environment. As a result, the use of bio-pesticides as an alternative to conventional pesticides has increased for control pests. Purpose: The investigation of both male and female rats' physiological status characteristics in relation to a single oral dose toxicity of Metarhizium anisopliae. Material and Methods: The local isolate of M. anisopliae (AUMC 5130)'s metabolic crude (MaC) and wettable powder formulation (MaF) were evaluated on Sprague Dawley male and female rats. Results: In either of the treated groups, there was no indication of a fatality or toxic effects. The results indicated that there were highly significant increase leucocyte and total erythrocyte counts of male and female treated with MaF and MaC, respectively, compared with control. Also, significant, and insignificant increase in male and female platelet count (Plt) treated with MaF and MaC, respectively. Significant, insignificant, and highly significant increase in male and female ALT, AST, and ALP, respectively, treated with both products (MaF and MaC) of the tested fungus. While lipid profile (T. cholesterol, HDL, LDL and VLDL), levels were decrease in both male and female rats treated with both MaC and MaF compared with control. There have been observed physiological changes in the body weight gain and tissue somatic index of control and all treated animals. When used as bio-insecticides, MaF and MaC products had the opposite effect on body weight gain in rats -a considerable increase -when compared to control groups.

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Section: Determination Of Oral Ld50mentioning

confidence: 99%

Section: Acute Oral Ld50 Studymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Hematological and Biochemical Alterations Induced by Two Products from Metarhizium anisopliae after Oral Administration in Male and Female Albino Rats

Ahmed,

El- Saadany,

Kotb

et al. 2023

Journal of Plant Protection and Pathology

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“…The blood from the dry tube made it possible to obtain serum which was stored at -4 °C for the assay of biochemical parameters. Analysis of the lipid profile (total cholesterol, HDL-cholesterol and triglycerides), liver function (total proteins, bilirubin, alkaline phosphatase, ALAT and ASAT), renal function (creatinine and urea) and blood sugar was performed using kits from Fortress diagnostics (United Kingdom), with procedures based on colorimetric method [12][13][14][15]. The liver, kidneys, spleen, lungs and the heart were obtained, rinsed with 0.9% salt solution, then weighed and stored in formol 10% for histological analyzes.…”

Section: Oral Subacute Toxicity Testmentioning

confidence: 99%

Study of the Subacute Toxicity of Dry Bark of Albizia ferruginea (Mimosaceae) (Guill. &Perr.) Berth. in Wistar Albino Rats

Minoue Kuum,

Tchadji,

Ndji Otto

et al. 2022

J. Pharm. Med. Res.

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This present work aimed to assess the subacute toxicity of the total aqueous extract of the dry bark of Albizia ferruginea in rats. Subacute toxicity was done in accordance with 2008 OECD Guideline 407, for oral toxicity at a daily dose for 28 days in rodents. The animals were divided into six groups of 10 rats each (5 males and 5 females). One control group received 10 mL/kg of distilled water, three groups received 200, 400 and 800 mg/kg of extract respectively, one satellite control group and one satellite treated group received 10 mL/kg of distilled water and 800 mg/kg extract respectively. After 28 days of treatment, the satellite groups were left under observation without treatment for an additional 14 days. Behavior, body weight and death rate were monitored during the experimental period. The relative weight of some organs, hematological and biochemical parameters and the histopathological study of the liver, kidneys and lungs were evaluated at the end of the experiment. There were no significant effects on body weight gain and the relative weight of organs investigated. At the 800 mg/kg dose, there was a significant increase in the level of monocytes by 26.53%; the mean corpuscular hemoglobin content (MCHT) of 18.18%; and in the corpuscular hemoglobin concentration (MCHC) of 20.70 %, only in male rats. ALT and ASAT activity were increased significantly in both male and female rats. These increases were not seen in satellite treated rats. The histology of the organs investigated showed no difference when comparing the treated rats to the control rats. The subacute toxicity study of total aqueous extract of the dry bark of Albizia ferruginea did not show any signs of significant toxicity for parameters studied in rats.

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TMT-based quantitative proteomics analysis of Sprague-Dawley rats liver reveals Triphenyltin induced liver damage and lipid metabolism disorders

Ren,

Mao,

et al. 2024

Pesticide Biochemistry and Physiology

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Biosafety evaluation of two Beauveria bassiana products on female albino rats using acute oral test

Cited by 3 publications

References 64 publications

Hematological and Biochemical Alterations Induced by Two Products from Metarhizium anisopliae after Oral Administration in Male and Female Albino Rats

Hematological and Biochemical Alterations Induced by Two Products from Metarhizium anisopliae after Oral Administration in Male and Female Albino Rats

Study of the Subacute Toxicity of Dry Bark of Albizia ferruginea (Mimosaceae) (Guill. &Perr.) Berth. in Wistar Albino Rats

TMT-based quantitative proteomics analysis of Sprague-Dawley rats liver reveals Triphenyltin induced liver damage and lipid metabolism disorders

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