Biosafety, Antioxidant Status, and Metabolites in Urine after Consumption of Dried Cranberry Juice in Healthy Women:  A Pilot Double-Blind Placebo-Controlled Trial

Abstract

This study assessed the effect of an 8 week consumption of dried cranberry juice (DCJ) on 65 healthy young women. Basic biochemical and hematological parameters, antioxidant status, presence of metabolites in urine, and urine ex vivo antiadherence activity were determined throughout the trial. A 400 mg amount of DCJ/day had no influence on any parameter tested. A 1200 mg amount of DCJ/day resulted in a statistically significant decrease in serum levels of advanced oxidation protein products. This specific protective effect against oxidative damage of proteins is described here for the first time. Urine samples had an inhibitory effect on the adhesion of uropathogenic Escherichia coli strains, but no increase in urine acidity was noted. Hippuric acid, isomers of salicyluric and dihydroxybenzoic acids, and quercetin glucuronide were identified as the main metabolites. In conclusion, cranberry fruits are effective not only in the prevention of urinary tract infection but also for the prevention of oxidative stress.

Chronic consumption of a low calorie, high polyphenol cranberry beverage attenuates inflammation and improves glucoregulation and HDL cholesterol in healthy overweight humans: a randomized controlled trial

“…In addition to GSH:GSSG ratio, we noted that SOD activity but not GPx was greater after chronic CEB consumption. These results are consistent with Duthie et al [11] and Valentova et al [45].…”

Inhibitory effect of plant phenolics on fMLP-induced intracellular calcium rise and chemiluminescence of human polymorphonuclear leukocytes and their chemotactic activityin vitro

“…The known biological effects regarding the consumption of quercetin and gallic acid demonstrated in various clinical studies are in accordance with this assumption. Increased quercetin intake reduced circulating levels of various markers of oxidative stress: oxidized LDL, malondialdehyde, and advanced oxidation protein products (Boots et al, 2011;Egert et al, 2009;Valentova et al, 2007). Gallic acid used topically on the skin showed evidence of anti-aging activities when measured by skin elasticity (Manosroi et al, 2011).…”

Berry Fruits as a Source of Biologically Active Compounds: The Case of Lonicera Caerulea

“…Quantities of these compounds vary depending on a number of the factors 46 . Table 2 shows a comparison of L. caerulea phenolic fraction anthocyanin content with those of Vaccinium macrocarpon 90 and Vitis vinifera 91 .…”