BIOS Instant Notes in Analytical Chemistry

Kealey, D.; Haines, P. J.

doi:10.4324/9780203645444

Cited by 24 publications

(14 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The isocratic system is a system in which the composition of the same phase of motion during measurement, while the gradient system is a system in which the mobile phase composition changes during the measurement. [17] The variation in the comparison of the components of the mobile phase influences the peak retention time resulting from the compound and influences the polarity of the mobile phase. [18] The effect of variation in the flow rate will affect the retention time of the compound.…”

Section: Discussionmentioning

confidence: 99%

Development and validation of simple simultaneous analysis for amlodipine and glibenclamide by nonderivatization high-performance liquid chromatography-fluorescence

Saputri

Alawiyah

Firsty

et al. 2018

J Adv Pharm Technol Res

View full text Add to dashboard Cite

Studies have shown that about 65% of diabetics have hypertension. Treatment for diabetic patients with hypertension is usually given a combination of drugs such as amlodipine (AML) and glibenclamide (GLI). The aim of this study was to develop and validate the simple simultaneous analysis method for separation of AML and GLI using high-performance liquid chromatography (HPLC) with fluorescence detector without derivatization. The arrangement of isocratic and gradient methods, mobile phase compositions, and flow rates to develop and validate the simple simultaneous analysis method for separation of AML and GLI by nonderivatization HPLC fluorescence was done. Optimum condition was obtained using an RP 18 (125 mm × 4 mm, i.d., 5 μm) and guard column RP 18 (4 mm × 4 mm, i.d., 5 μm) with mobile phase composition containing acetonitrile and phosphate buffer pH 3.0 using a 20:80 gradient condition at flow rate 1.0 ml/min measured at 361 nm for λ excitation and 442 nm for λ emission for AML and 235 nm for λ excitation and 354 nm for λ emission for GLI. The analysis of AML and GLI demonstrated a valid result with r2 value 0.999, recoveries were 100.04% and 99.14% relative standard deviations were 0.508% and 0,797%, respectively, detection limits were 0.055 and 0.104 μg/ml, and quantification limits were 0.166 and 0.316 μg/ml, respectively. An accurate method of separation for AML and GLI using HPLC with fluorescence detector without derivatization has been validated.

show abstract

Section: Discussionmentioning

confidence: 99%

Development and validation of simple simultaneous analysis for amlodipine and glibenclamide by nonderivatization high-performance liquid chromatography-fluorescence

Saputri

Alawiyah

Firsty

et al. 2018

J Adv Pharm Technol Res

View full text Add to dashboard Cite

show abstract

“…A representative sample is what truly reflects the composition of the material to be analyzed within the context of a defined analytical problem. [42]…”

Section: Methods and Analysismentioning

confidence: 99%

Pattern identification of lung cancer patients based on body constitution questionnaires (BCQ) and glycoproteomics for precision medicine

et al. 2019

View full text Add to dashboard Cite

Background: The patient's pattern identification has been used for personalized medicine in traditional Korean medicine (TKM) and aims for patient-specific therapy by Korean medical doctors. The pattern identification in this trial will be diagnosed from body constitution questionnaire (BCQ) with a more objective diagnosis of it but this method still needs a more concrete scientific basis. Glycoproteins are well-known to be associated with diseases (especially cancers) so glycoproteomics can be applied to differentiate pattern identification types of lung cancer patients. Thus, for the first time proteomics approach will be applied to the pattern identification by comparing BCQ assessment in order to establish a scientific basis with clinical proteomics for precision medicine. Methods: This observational trial will at first diagnose the pattern identification types of lung cancer patients with BCQ assessment and then elucidate their relationships with proteomics. Blood samples will be collected before surgery along with clinical information of participants. The patients’ pattern identification in TKM will be diagnosed from BCQ assessment. Then, lung cancer patients will be divided and pooled into 3 lung cancer entire (LCE) groups according to their pattern identification types (Xu, Stasis, or Gentleness). Three lung cancer representative (LCR) groups will be selected and pooled from each LCE group by selecting those with the same control factors. The 3 LCE groups and the 3 LCR groups from lung cancer patients will be independently analyzed through the glycoproteomics approach based on the patients’ pattern identification. Glycoproteins from the 6 groups will be identified through proteomics approach and then categorized for analysis. Discussion: This study intends to diagnose pattern identification of patients in TKM with BCQ assessment and proteomics approach. The identification of the glycoproteins in each group will lead to the scientific foundation of personalized medicine in TKM according to patients’ pattern identification for lung cancer therapy. We intend to (1) diagnose the pattern identification types of lung cancer patients with BCQ under the framework of TKM; (2) evaluate BCQ assessment with glycoproteomics approach for precision medicine. Trial registration: ClinicalTrials.gov NCT03384680. Registered 27 December 2017. Retrospectively registered.

show abstract

“…FTIR Analysis. In complex molecules, functional groups are typically the most important structural components [32]. FTIR spectroscopy is helpful in this regard, having been used for many years to determine the distribution of functional groups in lubricating oils [33].…”

Section: Chemical Characterization Of Oil Samplesmentioning

confidence: 99%

“…Minimal changes occurred in the RCs of these compounds with heating. As summarized in Table 1, dioctyldiphenylamine (50) in the oils generated N-(2-methylheptan-2-yl)-N-phenylaniline (25) and bis(4-(tert-butyl)phenyl)amine (26), while triphenyl phosphate (28), diphenyl tolyl phosphate (29,31,32), and phenyl ditolyl phosphate (36,38,40) were produced from tri-otolyl phosphate. It was reasonably inferred that the antioxidants and antiwear agents were all unstable, even under storage conditions.…”

Section: Chemical Characterization Of Oil Samplesmentioning

confidence: 99%

Effect of Temperature on the Chemical Composition and Physicochemical Properties of Diester Aviation Lubrication Oil

Yao

Zhang

Hu³

et al. 2020

International Journal of Chemical Engineering

View full text Add to dashboard Cite

High temperature is the main factor responsible for degrading the lubrication and antiwear properties of aero-lubricating oils. Accordingly, this study assessed the effects of thermal treatment of diester aviation lubricating oil and the associated mechanism. Fourier-transform infrared spectroscopy and gas chromatography/mass spectrometry analyses showed that low-molecular-weight compounds, such as monoesters, diesters, alcohols, and olefins, were the primary degradation products. An assessment of the degradation mechanism of bis(2-ethylhexyl)decanedioate showed that pyrolysis, resulting in the cleavage of β-C–H and C–C bonds, was the main process involved. Additional investigation using advanced polymer chromatography showed that the molecular weights of oil samples changed slightly at high temperatures, while the viscosity and viscosity-temperature index values were relatively stable. High-pressure differential scanning calorimetry established that the thermal oxidation stability of these oils decreased above 250°C. Finally, variations in the chemical compositions of the oil samples were found to be highly correlated with changes in physicochemical properties during thermal processing, with the formation of low-molecular-weight polar compounds greatly increasing the acid numbers of the oils.

show abstract

BIOS Instant Notes in Analytical Chemistry

Cited by 24 publications

References 0 publications

Development and validation of simple simultaneous analysis for amlodipine and glibenclamide by nonderivatization high-performance liquid chromatography-fluorescence

Development and validation of simple simultaneous analysis for amlodipine and glibenclamide by nonderivatization high-performance liquid chromatography-fluorescence

Pattern identification of lung cancer patients based on body constitution questionnaires (BCQ) and glycoproteomics for precision medicine

Effect of Temperature on the Chemical Composition and Physicochemical Properties of Diester Aviation Lubrication Oil

Contact Info

Product

Resources

About