Bioresponsive supramolecular hydrogels for hemostasis, infection control and accelerated dermal wound healing

Preman, Namitha K.; Sindhu, S; Prabhu, Ashwini; Shaikh, Sadiya Bi; Vipin, C; Barki, Rashmi R.; Bhandary, Yashodhar P.; Rekha, P. D.; Johnson, Renjith P.

doi:10.1039/d0tb01468k

Cited by 45 publications

(23 citation statements)

References 63 publications

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“…Thiolation of the polymers is a novel approach for improving the healing properties of polymers and alleviating associated side effects. Thiolated polymers are reported to have superior mucoadhesion, in situ gelling, poly glycoprotein (P-gp) enzyme inhibition, better control over drug release, and various other biological applications via nanotechnology chitin-covered LCH have also demonstrated promising wound management (Vellayappan et al, 2016;Han et al, 2019;Preman et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

RETRACTED ARTICLE: Local anesthetic lidocaine-encapsulated polymyxin–chitosan nanoparticles delivery for wound healing: in vitro and in vivo tissue regeneration

Yao

et al. 2021

Drug Delivery

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In relieving local pains, lidocaine, one of ester-type local anesthetics, has been used. To develop the lidocaine membranes of enhanced local anesthetic effects, we have designed to establish the composition of wound dressings based on lidocaine chloride (LCH) (anesthetic drug)-loaded chitosan (CS)/ polymyxin B sulfate (PMB). The LCH membranes (LCH-CS/PMB) was fabricated by the LCH oxide solutions within the CS/PMB matrix. The influences of different experimental limitations on CS/PMB membrane formations were examined. The double membrane particle sizes were evaluated by scanning electron microscopy (HR-SEM). Additionally, antibacterial efficacy was developed for gram-positive and negative microorganisms. Moreover, we examined in vivo healing of skin wounds formed in mouse models over 16 days. In contrast to the untreated wounds, rapid healing was perceived in the LCH-CS/ PMB-treated wound with less damaging. These findings indicate that LCH-CS/PMB-based bandaging materials could be a potential innovative biomaterial for tissue repair and regeneration for wound healing applications in an animal model.

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Section: Introductionmentioning

confidence: 99%

RETRACTED ARTICLE: Local anesthetic lidocaine-encapsulated polymyxin–chitosan nanoparticles delivery for wound healing: in vitro and in vivo tissue regeneration

Yao

et al. 2021

Drug Delivery

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“…Moreover, depending on the wound environment, the degradation rate of hydrogels can be modified thus releasing more bioactive molecules. 68 , 69 , 70 , 71 …”

Section: Hydrogels For Wound Healing Applicationsmentioning

confidence: 99%

Wound healing applications of creams and “smart” hydrogels

Stan

Tănase

Avram³

et al. 2021

Experimental Dermatology

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“…Adhesive hydrogels were three-dimensional polymer networks that cross-linked either physically or chemically [1][2][3], which were used for tissue adhesion [4][5][6][7][8], hemostasis [9][10][11][12], and sealing against the leakage of air and body fluids during surgical procedures [13][14][15]. Various studies have been carried out to develop synthetic (e.g., cyanoacrylates) and protein [e.g., collagen,bovine serum albumin (BSA) and fibrin] adhesive products [16,17].…”

Section: Introductionmentioning

confidence: 99%

Highly stretchable, compressible, adhesive hydrogels with double network

Guo

Zeng

et al. 2021

J Polym Res

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In this work, a double network bovine serum albumin-polyacrylamide (BSA-PAM) adhesive hydrogel was fabricated, in which combination of physical interactions including hydrogen bonds and chain entanglements, and chemical covalent photo-crosslinking. The BSA-PAM hydrogel exhibited excellent mechanical and adhesive properties. The composite hydrogel not only demonstrated excellent tensile properties (maximum force elongation 1552%~2037%), but also displayed extremely high fatigue resistance even when subjected to compress strains of up to 85%. More importantly, the BSA-PAM hydrogel showed excellent adhesiveness to various substrates (90 kPa~150 kPa for glass and 9.74 kPa~35.09 kPa for pigskin). This work provided a facile way of fabricating tough, stretchable and adhesive BSA-PAM hydrogels.

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Bioresponsive supramolecular hydrogels for hemostasis, infection control and accelerated dermal wound healing

Abstract: Injectable, drug-releasing hydrogel scaffolds with multifunctional properties including haemostasis and anti-bacterial activity are essential for successful wound healing, however, the design of an ideal material is still challenging. Herein, we...

Cited by 45 publications

References 63 publications

RETRACTED ARTICLE: Local anesthetic lidocaine-encapsulated polymyxin–chitosan nanoparticles delivery for wound healing: in vitro and in vivo tissue regeneration

RETRACTED ARTICLE: Local anesthetic lidocaine-encapsulated polymyxin–chitosan nanoparticles delivery for wound healing: in vitro and in vivo tissue regeneration

Wound healing applications of creams and “smart” hydrogels

Highly stretchable, compressible, adhesive hydrogels with double network

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