Bioresponsive nanotherapy for preventing dental caries by inhibiting multispecies cariogenic biofilms

Liu, Danfeng; Ma, Xianbin; Ji, Yaoting; Chen, Rourong; Zhou, Shuhui; Yao, Hantao; Zhang, Zichen; Ye, Mengjie; Xu, Zhigang; Du, Minquan

doi:10.1016/j.bioactmat.2021.12.016

Cited by 34 publications

(25 citation statements)

References 51 publications

(89 reference statements)

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“…However, the indiscriminate utilization of antibiotics has been causing the emergence of many drug-resistant bacteria [ 3 ]. Therefore, developing effective alternative strategies to manage bacterial infections without inducing multi-drug resistance is urgently needed [ 4 ]. In recent years, various approaches such as photodynamic therapy, chemodynamic therapy, and photothermal therapy (PTT) have emerged to fight bacteria.…”

Section: Introductionmentioning

confidence: 99%

Architecting polyelectrolyte hydrogels with Cu-assisted polydopamine nanoparticles for photothermal antibacterial therapy

You

Mao

et al. 2022

Materials Today Bio

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Section: Introductionmentioning

confidence: 99%

Architecting polyelectrolyte hydrogels with Cu-assisted polydopamine nanoparticles for photothermal antibacterial therapy

You

Mao

et al. 2022

Materials Today Bio

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“…After 45 days, the rats were sacrificed. Carious lesions on the smooth surface (Smo) and the sulcal surface (Sul) were quantitatively assessed via Keyes’ scoring [ 56 ]. According to Keyes’ scoring, the depth of carious lesions was divided into the following levels: enamel only (E), slightly dentinal (Ds, < 1/4 of the dentin region), moderate dentinal (Dm, 1/4–3/4 of the dentin region), and extensive dentinal (Dx, > 3/4 of the dentin region).…”

Section: Resultsmentioning

confidence: 99%

“…9 A, compared with the control group, the carious lesions were significantly decreased in the LA/TCS@PLGA-NPs group ( P < 0.05), while there were no significant differences between the control group and other treatment groups ( P > 0.05). For the sulcal surface, the carious lesions were evaluated based on the following levels [ 56 ]: total lesions (E + Ds + Dm + Dx), initial lesions (Ds + Dm + Dx), moderate lesions (Dm + Dx), and extensive lesions (Dx). As shown in Fig.…”

Section: Resultsmentioning

confidence: 99%

Lactobacillus cell envelope-coated nanoparticles for antibiotic delivery against cariogenic biofilm and dental caries

Weng

Guo

et al. 2022

J Nanobiotechnol

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Background Due to their prevalence, dental caries ranks first among all diseases endangering human health. Therefore, the prevention of caries is of great significance, as caries have become a serious public health problem worldwide. Currently, using nanoscale drug delivery systems to prevent caries has received increased attention. However, the preventive efficacy of these systems is substantially limited due to the unique physiological structure of cariogenic biofilms. Thus, novel strategies aimed at combating cariogenic biofilms to improve preventive efficiency against caries are meaningful and very necessary. Herein, inspired by cell membrane coating technology and Lactobacillus strains, we coated triclosan (TCS)-loaded poly(lactic-co-glycolic acid) (PLGA) nanoparticles (TCS@PLGA-NPs) with an envelope of Lactobacillus (LA/TCS@PLGA-NPs) and investigated their potential as a nanoparticle delivery system against cariogenic biofilms and dental caries. Results LA/TCS@PLGA-NPs were successfully prepared with favorable properties, including a coated envelope, controllable size, negative charge, sustained drug-release kinetics and so on. The LA/TCS@PLGA-NPs inherited native properties from the source cell surface, thus the LA/TCS@PLGA-NPs adhered to S. mutans, integrated into the S. mutans biofilm, and interfered with the biofilm formation of S. mutans. The nanoparticles significantly inhibited the activity, biomass and virulence gene expression of S. mutans biofilms in vitro. Additionally, LA/TCS@PLGA-NPs exhibited a long-lasting inhibitory effect on the progression of caries in vivo. The safety performance of the nanoparticles is also favorable. Conclusions Our findings reveal that the antibiofilm effect of LA/TCS@PLGA-NPs relies not only on the inheritance of native properties from the Lactobacillus cell surface but also on the inhibitory effect on the activity, biomass and virulence of S. mutans biofilms. Thus, these nanoparticles could be considered feasible candidates for a new class of effective drug delivery systems for the prevention of caries. Furthermore, this work provides new insights into cell membrane coating technology and presents a novel strategy to combat bacterial biofilms and associated infections. Graphical Abstract

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“…Liu et al once designed an amphiphilic and pHresponsive polymer, which can self-assemble into spherical structure in a neutral condition and disassemble under an acidic environment. Considering the lower pH in the caries environment, they encapsulated Ce 6 with the polymer for PDT on demand (Figure 3B) (Liu et al, 2021a). A. Balhaddad et al constructed a nanoplatform by assembling TBO and magnetic Fe 3 O 4 .…”

Section: Organic Small Moleculesmentioning

confidence: 99%

Dental Materials for Oral Microbiota Dysbiosis: An Update

Zhu

Chu

Luo

et al. 2022

Front. Cell. Infect. Microbiol.

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The balance or dysbiosis of the microbial community is a major factor in maintaining human health or causing disease. The unique microenvironment of the oral cavity provides optimal conditions for colonization and proliferation of microbiota, regulated through complex biological signaling systems and interactions with the host. Once the oral microbiota is out of balance, microorganisms produce virulence factors and metabolites, which will cause dental caries, periodontal disease, etc. Microbial metabolism and host immune response change the local microenvironment in turn and further promote the excessive proliferation of dominant microbes in dysbiosis. As the product of interdisciplinary development of materials science, stomatology, and biomedical engineering, oral biomaterials are playing an increasingly important role in regulating the balance of the oral microbiome and treating oral diseases. In this perspective, we discuss the mechanisms underlying the pathogenesis of oral microbiota dysbiosis and introduce emerging materials focusing on oral microbiota dysbiosis in recent years, including inorganic materials, organic materials, and some biomolecules. In addition, the limitations of the current study and possible research trends are also summarized. It is hoped that this review can provide reference and enlightenment for subsequent research on effective treatment strategies for diseases related to oral microbiota dysbiosis.

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Bioresponsive nanotherapy for preventing dental caries by inhibiting multispecies cariogenic biofilms

Cited by 34 publications

References 51 publications

Architecting polyelectrolyte hydrogels with Cu-assisted polydopamine nanoparticles for photothermal antibacterial therapy

Architecting polyelectrolyte hydrogels with Cu-assisted polydopamine nanoparticles for photothermal antibacterial therapy

Lactobacillus cell envelope-coated nanoparticles for antibiotic delivery against cariogenic biofilm and dental caries

Dental Materials for Oral Microbiota Dysbiosis: An Update

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