Bioresorption of Ceramic Strontium-85-Labeled Calcium Phosphate Implants in Dog Femora

Renooij, Willem; Hoogendoorn, Hugh; Visser, W. J.; Lentferink, R. H.; Schmitz, Maximilian; Ieperen, H. Van; Oldenburg, S.J.; Janssen, W. M.; Akkermans, L.M.A.; Wittebol, P

doi:10.1097/00003086-198507000-00034

Cited by 74 publications

(18 citation statements)

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“…The resorption rate of β-TCP is higher, as compared to α-TCP, and to highly cristalline, sintered HA [19]. Renooji et al demonstrated that sintered β-TCP was subject to biodegradation, whereas hydroxyapatite was not affected by bioresorption processes 50 weeks after implantation in dog [20]. They concluded that superior bone formation took place in the grafted β-TCP comparable to the grafted HA.…”

Section: Discussionmentioning

confidence: 99%

A bioactive collagen-β tricalcium phosphate scaffold for tissue engineering

et al. 2006

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Collagen-phosphate composites (COL/β-TCP) are novel materials that have the potential to be used as bone analogues. The aim of our study was to develop a porous bioactive material composed of type I collagen, the main bone protein and tricalcium phosphate, the mineral phase of natural bone, and investigate their in vitro biocompatibility in a human dermal fibroblast culture system. In order to obtain the bioactive materials, type I collagen was isolated from bovine tendon and characterized by physicochemical methods. β-TCP was obtained from calcium carbonate by thermal decomposition at 900 • C temperature. The powder was examined with X-ray diffraction. Two variants of COL/β-TCP scaffolds (P1 and P2) were prepared and examined by scanning electron microscopy. Our results revealed a microporous structure with small white aggregates of β-TCP, non-homogenous scattered in the collagen framework without any preferential orientation. The biocompatibility of the obtained scaffolds was tested by biochemical and histological methods on human fibroblast cultures. Both materials acted as good subtrates for human dermal fibroblast proliferation and migration.

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Section: Discussionmentioning

confidence: 99%

A bioactive collagen-β tricalcium phosphate scaffold for tissue engineering

et al. 2006

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“…In addition, nine cases were classified as "other." Tumors were located in the femur (15 patients), humerus (3), ilium (3), tibia (3), and at other sites (6). Maximum dimensions of the tumors ranged from 2 to 15 cm; mean size was 6.3 cm (SD ϭ 3.9).…”

Section: Methodsmentioning

confidence: 99%

Comparison of hydroxyapatite and beta tricalcium phosphate as bone substitutes after excision of bone tumors

Ogose¹,

Hotta²,

Kawashima³

et al. 2004

J Biomed Mater Res

265

177

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Long-term results are reported in 23 patients and short-term results in 30 patients presenting with bone tumors treated by curettage or resection followed by implantation of hydroxyapatite (HA) or highly purified beta-tricalcium phosphate (␤-TCP), respectively. Mean follow-up was 97 and 26 months in cases involving HA implantation and ␤-TCP implantation, respectively. Radiographs revealed HA incorporation into host bone in all but two cases; moreover, no obvious evidence of HA biodegradation was observed. A single patient exhibited late deformity following implantation of HA. All grafted ␤-TCP was, at least partially, absorbed and replaced by newly formed bone. The mean period required for the disappearance of radiolucent zones between the ceramics and host bone was 17 weeks in HA and 9.7 weeks in ␤-TCP. Highly purified ␤-TCP appears to be advantageous relative to HA for surgical intervention in bone tumors consequent to the nature of remodeling and superior osteoconductivity.

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“…Numerous works have focused on the use of synthetic calcium phosphate ceramics such as hydroxyapatite (HA) and beta-tricalcium phosphate (b-TCP) [8][9][10][11][12][13][14][15][16][17][18][19]. Hydroxyapatite was reported to hardly resorb [8][9][10][11][12], whereas b-TCP was reported to degrade slowly in vivo and was completely replaced with remodeled host bone [11][12][13][14][15][16][17][18][19][20][21][22]. Therefore, the biodegradable b-TCP has been considered a promising carrier for BMP controlled release.…”

Section: Introductionmentioning

confidence: 99%

Ectopic osteoinduction and early degradation of recombinant human bone morphogenetic protein-2-loaded porous β-tricalcium phosphate in mice

Yang

et al. 2005

Biomaterials

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Bioresorption of Ceramic Strontium-85-Labeled Calcium Phosphate Implants in Dog Femora

Cited by 74 publications

References 0 publications

A bioactive collagen-β tricalcium phosphate scaffold for tissue engineering

A bioactive collagen-β tricalcium phosphate scaffold for tissue engineering

Comparison of hydroxyapatite and beta tricalcium phosphate as bone substitutes after excision of bone tumors

Ectopic osteoinduction and early degradation of recombinant human bone morphogenetic protein-2-loaded porous β-tricalcium phosphate in mice

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