Bioresorbable metals in cardiovascular stents: Material insights and progress

Toong, Daniel Wee Yee; Ng, Jaryl; Huang, Yingying; Wong, Philip; Leo, Hwa Liang; Venkatraman, Subbu; Ang, Hui Ying

doi:10.1016/j.mtla.2020.100727

Cited by 35 publications

(27 citation statements)

References 135 publications

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“…The use of bioresorbable stents is considered a revolution in interventional cardiology [ 82 ]. Such devices are fabricated from materials that provide transient support and progressively degrade, being dissolved or absorbed in the body after the remodeling process [ 13 , 30 , 31 , 79 , 83 ].…”

Section: Evolution Of Cardiovascular Stentsmentioning

confidence: 99%

“…As iron has a slow degradation rate, combining it with other metals in adequate proportions accelerates corrosion without sacrificing the required mechanical properties. Specifically, promising results have been obtained with Fe-35Mn (iron alloy containing ~35% manganese), which has similar ultimate tensile strength and yield strength to stainless steel but with a degradation rate that is three to eight times faster [ 82 ].…”

Section: Stent Optimizationmentioning

confidence: 99%

“… Schematic representation of an ideal stent’s properties. Created based on information from the literature [ 23 , 82 , 84 , 103 , 135 ]. …”

Section: Figurementioning

confidence: 99%

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Cardiovascular Stents: A Review of Past, Current, and Emerging Devices

et al. 2021

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One of the leading causes of morbidity and mortality worldwide is coronary artery disease, a condition characterized by the narrowing of the artery due to plaque deposits. The standard of care for treating this disease is the introduction of a stent at the lesion site. This life-saving tubular device ensures vessel support, keeping the blood-flow path open so that the cardiac muscle receives its vital nutrients and oxygen supply. Several generations of stents have been iteratively developed towards improving patient outcomes and diminishing adverse side effects following the implanting procedure. Moving from bare-metal stents to drug-eluting stents, and recently reaching bioresorbable stents, this research field is under continuous development. To keep up with how stent technology has advanced in the past few decades, this paper reviews the evolution of these devices, focusing on how they can be further optimized towards creating an ideal vascular scaffold.

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Section: Evolution Of Cardiovascular Stentsmentioning

confidence: 99%

Section: Stent Optimizationmentioning

confidence: 99%

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Cardiovascular Stents: A Review of Past, Current, and Emerging Devices

et al. 2021

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“…Engineered or natural materials that are used directly to supplement the functions of living tissue are known as biomaterials and they have been utilized as implant materials for a long time in the field of medical science [ [1] , [2] , [3] , [4] ]. Conventional non-degradable metallic biomaterials, such as stainless steels (SS), cobalt–chromium (Co–Cr) alloys, and titanium (Ti) and some of its alloys, are generally used as permanent or temporary implants to restore function by providing support to hard tissues.…”

Section: Introductionmentioning

confidence: 99%

Recent research and progress of biodegradable zinc alloys and composites for biomedical applications: Biomechanical and biocorrosion perspectives

Kabir

Munir

Wen

et al. 2021

Bioactive Materials

225

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Biodegradable metals (BMs) gradually degrade in vivo by releasing corrosion products once exposed to the physiological environment in the body. Complete dissolution of biodegradable implants assists tissue healing, with no implant residues in the surrounding tissues. In recent years, three classes of BMs have been extensively investigated, including magnesium (Mg)-based, iron (Fe)-based, and zinc (Zn)-based BMs. Among these three BMs, Mg-based materials have undergone the most clinical trials. However, Mg-based BMs generally exhibit faster degradation rates, which may not match the healing periods for bone tissue, whereas Fe-based BMs exhibit slower and less complete in vivo degradation. Zn-based BMs are now considered a new class of BMs due to their intermediate degradation rates, which fall between those of Mg-based BMs and Fe-based BMs, thus requiring extensive research to validate their suitability for biomedical applications. In the present study, recent research and development on Zn-based BMs are reviewed in conjunction with discussion of their advantages and limitations in relation to existing BMs. The underlying roles of alloy composition, microstructure, and processing technique on the mechanical and corrosion properties of Zn-based BMs are also discussed.

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“…В качестве основы подобных разработок было предложено использование магниевых сплавов, таких как AZ31 [1,2], AZ91 [3,4] и WE43 [4][5][6]. WE43 уже нашел применение в клинической практике для изготовления стентов и крепежных элементов для остеосинтеза [7][8][9][10][11]. Подобный выбор объясняется сходством механических свойств сплавов магния и костной ткани человека [12], а также его способностью к биодеградации при контакте с биоактивными средами как в условиях in vitro, так и in vivo [12].…”

Section: Introductionunclassified

The Effect of Multiaxial Deformation on the Dynamics of Biodegradation and Cell Colonization of Alloy We43

Martynenko

Анисимова

Новрузов

et al. 2021

Rossijskij bioterapevtičeskij žurnal

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Introduction. The development of materials for bioresorbable implants is an urgent issue in medicine and materials science. Magnesium alloys are promising materials for this purpose. In particular, alloy WE43 (Mg-Y-Nd-Zr) has proven itself well in this field. However, the use of magnesium alloys is limited by a high degradation rate, which is often accompanied with nonuniform corrosion, which negatively affects the load bearing capacity of the product. In addition, the increased degradation rate usually seriously worsens the biocompatibility of magnesium alloys. Therefore, the study of the corrosion resistance of magnesium alloys, as well astheir biocompatibility, is an urgent task.Purpose of the study was to investigate the effect of multiaxial deformation (MAD), aimed at increasing the mechanical characteristics of the alloy WE43, on its biodegradation kinetics, as well as on cell colonization.Materials and methods. The alloy WE43 in two states – homogenized (WE43 hom) and strengthened by MAD (WE43 MAD) was investigated in this work. The kinetics of biodegradation was investigated on an xCELLigence RTCA Systems analyzer. A method for estimating the volume of hydrogen was used to study the process of gas formation, which was recorded using an automated digital microscope LionheartTM FX. The corrosive medium was a solution based on Dulbecco’s Modified Eagle’s Medium. A culture of mesenchymal multipotent stromal cells was used to study the colonization of the alloy surface by cells.Results. MAD of the alloy WE43 leads to a decrease in the biodegradation rate and the intensity of gas formation. The period of stabilization of biodegradation for the alloy after the MAD is 16 hours versus 3 hours for the alloy after homogenization. In this case, the volume of released hydrogen was 65.0 ± 4.4 mm3H2/mm3 alloy and 211.0 ± ± 21.1 mm3H2/mm3 alloy for the alloy after MAD and homogenization, respectively. MAD improves the biocompatibility of the alloy WE43, stimulating the colonization of mesenchymal multipotent stromal cells.Conclusion. MAD reduces biodegradation and improves the biocompatibility of the alloy WE43, which makes it a promising medical material, including for the purposes of oncoorthopedics

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Bioresorbable metals in cardiovascular stents: Material insights and progress

Cited by 35 publications

References 135 publications

Cardiovascular Stents: A Review of Past, Current, and Emerging Devices

Cardiovascular Stents: A Review of Past, Current, and Emerging Devices

Recent research and progress of biodegradable zinc alloys and composites for biomedical applications: Biomechanical and biocorrosion perspectives

The Effect of Multiaxial Deformation on the Dynamics of Biodegradation and Cell Colonization of Alloy We43

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