Bioresorbable electrospun mats of poly(D, L)-lactide/poly[(R, S)-3-hydroxybutyrate] blends for potential use in the treatment of difficult-to-heal skin wounds

Zięba, Magdalena; Włodarczyk, Jakub; Gupta, Abhishek; Pastusiak, Małgorzata; Chaber, Paweł; Janeczek, Henryk; Musioł, Marta; Sikorska, Wanda; Kaczmarczyk, Bożena; Kowalczuk, Marek; Savickas, Arūnas; Savickienė, Nijolė; Adamus, Grażyna

doi:10.1016/j.eurpolymj.2021.110334

Cited by 10 publications

(13 citation statements)

References 51 publications

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“…They are bioresorbed by the body and act as a carrier for releasing of the bioactive compounds. The lactic acid oligomers containing carboxyl and hydroxyl end groups were quantified by EMI-MS tandem mass spectrometry as degradation products of P(D,L)LA/a-PHB and P(D,L)LA/a-PHB/proanthocianidins (PCAN) [ 161 ]. However, the neat PLA did not have good mechanical properties and bioactivity, having a great impact on the limiting of its applications in wound-healing management.…”

Section: Wound Dressingsmentioning

confidence: 99%

“…Electrospinning is a simple, low-cost, and scalable technique to prepare polymeric nano- and microfibers with different diameters, from microns to around 30 nanometers [ 161 ]. This method is based on using electrostatic forces to produce continuous polymer fibers from polymer melt or solution.…”

Section: Wound Dressingsmentioning

confidence: 99%

“…In an attempt to reduce the effects of adverse antibiotics, modern wound dressings loaded with natural antimicrobial agents such as proanthocyanidins (PCAN) extracted from Pelargonium sidoides [ 161 ], Annona leaf extracts [ 164 ], babassu oil [ 19 ], Hypericum perforatum oil (HPO) [ 21 ], melanin [ 18 ], and arginine and chitosan [ 174 ] were developed. Immunomodulatory properties toward skin keratinocytes in vitro were related in the case of olive leaf extract (OLE) incorporation in poly(hydroxybutyrate-co-hydroxyvalerate) (PHBV) and PHB/poly(hydroxyoctanoate-co-hydroxydecanoate) (PHB/PHOHD) nanofibers, due to the antioxidant activity of oleuropein [ 175 ].…”

Section: Wound Dressingsmentioning

confidence: 99%

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Special Features of Polyester-Based Materials for Medical Applications

Darie-Niță¹,

Râpă

Frąckowiak

2022

Polymers

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This article presents current possibilities of using polyester-based materials in hard and soft tissue engineering, wound dressings, surgical implants, vascular reconstructive surgery, ophthalmology, and other medical applications. The review summarizes the recent literature on the key features of processing methods and potential suitable combinations of polyester-based materials with improved physicochemical and biological properties that meet the specific requirements for selected medical fields. The polyester materials used in multiresistant infection prevention, including during the COVID-19 pandemic, as well as aspects covering environmental concerns, current risks and limitations, and potential future directions are also addressed. Depending on the different features of polyester types, as well as their specific medical applications, it can be generally estimated that 25–50% polyesters are used in the medical field, while an increase of at least 20% has been achieved since the COVID-19 pandemic started. The remaining percentage is provided by other types of natural or synthetic polymers; i.e., 25% polyolefins in personal protection equipment (PPE).

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Section: Wound Dressingsmentioning

confidence: 99%

Section: Wound Dressingsmentioning

confidence: 99%

Section: Wound Dressingsmentioning

confidence: 99%

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Special Features of Polyester-Based Materials for Medical Applications

Darie-Niță¹,

Râpă

Frąckowiak

2022

Polymers

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“…Our previous research demonstrated the possibility of obtaining polymer delivery systems for potential wound treatment application in the form of electrospun mats with flexible properties ensuring compatibility with the wound topology from the poly(D,L)lactide/poly[(R,S)-3-hydroxybutyrate], P(D,L)LA/(R,S)-PHB, polymeric blend containing PCANs [ 29 ].…”

Section: Introductionmentioning

confidence: 99%

Designing of Drug Delivery Systems to Improve the Antimicrobial Efficacy in the Periodontal Pocket Based on Biodegradable Polyesters

Zięba,

Sikorska,

Musioł

et al. 2023

IJMS

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Delivery systems for biologically active substances such as proanthocyanidins (PCANs), produced in the form of electrospun nonwoven through the electrospinning method, were designed using a polymeric blend of poly(L-lactide-co-glycolide) (PLGA)and poly[(R,S)-3-hydroxybutyrate] ((R,S)-PHB). The studies involved the structural and thermal characteristics of the developed electrospun three-dimensional fibre matrices unloaded and loaded with PCANs. In the next step, the hydrolytic degradation tests of these systems were performed. The release profile of PCANs from the electrospun nonwoven was determined with the aid of UV–VIS spectroscopy. Approximately 30% of the PCANs were released from the tested electrospun nonwoven during the initial 15–20 days of incubation. The chemical structure of water-soluble oligomers that were formed after the hydrolytic degradation of the developed delivery system was identified through electrospray ionization mass spectrometry. Oligomers of lactic acid and OLAGA oligocopolyester, as well as oligo-3-hydroxybutyrate terminated with hydroxyl and carboxyl end groups, were recognized as degradation products released into the water during the incubation time. It was also demonstrated that variations in the degradation rate of individual mat components influenced the degradation pattern and the number of formed oligomers. The obtained results suggest that the incorporation of proanthocyanidins into the system slowed down the hydrolytic degradation process of the poly(L-lactide-co-glycolide)/poly[(R,S)-3-hydroxybutyrate] three-dimensional fibre matrix. In addition, in vitro cytotoxicity and antimicrobial studies advocate the use of PCANs for biomedical applications with promising antimicrobial activity.

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“…In addition to crystalline PHB, its synthetic counterpart, amorphous, atactic poly([R,S]-3-hydroxybutyrate) (R,S-PHB), is also used to modify PURs [ 3 ]. R,S-PHB is obtained through anionic ring-opening polymerization (ROP) of β-substituted β-lactones [ 15 ]. PLA and R,S-PHB degradation products are non-toxic and can finally be biodegraded into carbon dioxide and water.…”

Section: Introductionmentioning

confidence: 99%

Susceptibility to Degradation in Soil of Branched Polyesterurethane Blends with Polylactide and Starch

Brzeska

Jasik²,

Sikorska

et al. 2022

Polymers

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A very important method of reducing the amount of polymer waste in the environment is the introduction to the market of polymers susceptible to degradation under the influence of environmental factors. This paper presents the results of testing the susceptibility to degradation in soil of branched polyesterurethane (PUR) based on poly([R,S]-3-hydroxybutyrate) (R,S-PHB), modified with poly([D,L]-lactide) (PLA) and starch (St). Weight losses of samples and changes in surface morphology (SEM, OM and contact angle system) with simultaneously only slight changes in molecular weight (GPC), chemical structure (FTIR and 1HNMR) and thermal properties (DSC) indicate that these materials are subject to enzymatic degradation caused by the presence of microorganisms in the soil. Chemical modification of branched polyesterourethanes with R,S-PHB and their physical blending with small amounts of PLA and St resulted in a slow but progressive degradation of the samples.

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Bioresorbable electrospun mats of poly(D, L)-lactide/poly[(R, S)-3-hydroxybutyrate] blends for potential use in the treatment of difficult-to-heal skin wounds

Cited by 10 publications

References 51 publications

Special Features of Polyester-Based Materials for Medical Applications

Special Features of Polyester-Based Materials for Medical Applications

Designing of Drug Delivery Systems to Improve the Antimicrobial Efficacy in the Periodontal Pocket Based on Biodegradable Polyesters

Susceptibility to Degradation in Soil of Branched Polyesterurethane Blends with Polylactide and Starch

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