Bioresorbable drug-eluting magnesium-alloy scaffold: design and feasibility in a porcine coronary model

Wittchow, Eric; Adden, Nina; Riedmüller, J.; Savard, Claudine; Waksman, Ron; Braune, M

doi:10.4244/eijv8i12a218

Cited by 85 publications

(69 citation statements)

References 40 publications

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“…24,25 However, the optimal absorbable time of stents remains controversial. As we know, Mg alone has a rapid degradation rate in body fluid, that will lead to tissue overload with degradation products and will result in neointimal formation and elastic recoil.…”

Section: Discussionmentioning

confidence: 99%

Effectiveness of Biodegradable Magnesium Alloy Stents in Coronary Artery and Femoral Artery

Yue

Wang

Huang

et al. 2015

J Interven Cardiology

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Section: Discussionmentioning

confidence: 99%

Effectiveness of Biodegradable Magnesium Alloy Stents in Coronary Artery and Femoral Artery

Yue

Wang

Huang

et al. 2015

J Interven Cardiology

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“…The magnesium alloy scaffold is coated with sirolimus eluting drug and bioabsorbable poly-L-lactide (PLLA) polymer matrix coating [45][46][47][48][49][50][51][52][53][54].…”

Section: Introductionmentioning

confidence: 99%

Procedural safety and short-term outcome in asian men treated with magnesium bio-resorbable scaffold

Chye¹,

Arshad²,

Khir³

et al. 2017

Interventional-Cardiology.

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“…As paclitaxel release rate depends on PLGA degradation, which in turn depends on its lactide-co-glycolide ratio, Wittchow et al (45) Forty-seven first-generation DREAMS (1G) were implanted in 46 patients with 47 single de novo lesions. Silent ischemia, stable or unstable angina were the indication to percutaneous coronary intervention (PCI).…”

Section: Resorption Processmentioning

confidence: 99%

Magmaris: a new generation metallic sirolimus-eluting fully bioresorbable scaffold: present status and future perspectives

Rapetto¹,

Leoncini²

2017

J. Thorac. Dis.

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Drug-eluting stents (DES) have reached a high safety and efficacy profile, becoming the best option for percutaneous coronary interventions (PCI) based revascularization. However, despite their optimal performance, a few concerns remain regarding their use, mainly due to permanent caging of the vessels and its consequences, first of all late stent thrombosis (ST). Bioresorbable scaffolds (BRS) aim to overcome these issues. The results achieved in randomized controlled trials (RCT) by the first generation of poly-L-lactic acid (PLLA) based scaffolds were promising at 1 year, but the first long term reports (albeit flawed by nonoptimal implantation technique) have been disappointing, showing, for instance, an increased risk of ST and target vessel myocardial infarction (TV-MI). In such a scenario the advent of a newer generation magnesium (Mg) based BRS is welcome, mainly because of its innovative mechanical and chemical features coupled with well proven biocompatibility. Despite being in its infancy, this technology seems to promise a great potential.In our article, we review the Magmaris (Biotronik AG, Bülach, Switzerland) Mg BRS development from animal models to human use, underscore its best qualities and weaknesses, and provide hints of its possible future perspectives.

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Bioresorbable drug-eluting magnesium-alloy scaffold: design and feasibility in a porcine coronary model

Abstract: By selecting suitable paclitaxel-elution kinetics, it was feasible to develop a bioresorbable magnesium scaffold whose efficacy and healing characteristics in a porcine coronary model are comparable with those of established paclitaxel-eluting permanent metallic stents.

Cited by 85 publications

References 40 publications

Effectiveness of Biodegradable Magnesium Alloy Stents in Coronary Artery and Femoral Artery

Effectiveness of Biodegradable Magnesium Alloy Stents in Coronary Artery and Femoral Artery

Procedural safety and short-term outcome in asian men treated with magnesium bio-resorbable scaffold

Magmaris: a new generation metallic sirolimus-eluting fully bioresorbable scaffold: present status and future perspectives

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