Bioresorbable composite polymeric materials for tissue engineering applications

Hajebi, Sakineh; Nasr, Saeed Mohammadi; Rabiee, Navid; Bagherzadeh, Mojtaba; Ahmadi, Sepideh; Rabiee, Mohammad; Tahriri, Mohammadreza; Tayebi, Lobat; Hamblin, Michael R.

doi:10.1080/00914037.2020.1765365

Cited by 30 publications

(25 citation statements)

References 98 publications

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“…According to the manufacturer's specification, the WPI contained β-lactoglobulin (75.7 ± 1.4%), α-lactalbumin (14.7 ± 0.1%), and <4% BSA (BiPRO, Davisco Foods Int., Inc., Eden Prairie, MN, USA). It is known that the heat treatment of a WPI solution above 60 °C promotes the gelation process due to protein denaturation and the formation of new disulfide bonds with the formation of a three-dimensional network [52][53][54][55]. To remove unwanted biofilms from the surface of the formed hydrogels, which can provoke additional bacterial contamination, all samples were additionally sterilized by autoclaving at 121 °C for 15 min (Figure 1a).…”

Section: Preparation and Characterization Of Antibacterial Wpi Hydrogelsmentioning

confidence: 99%

WPI Hydrogels with a Prolonged Drug-Release Profile for Antimicrobial Therapy

et al. 2022

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Infectious sequelae caused by surgery are a significant problem in modern medicine due to their reduction of therapeutic effectiveness and the patients’ quality of life.Recently, new methods of local antimicrobial prophylaxis of postoperative sequelae have been actively developed. They allow high local concentrations of drugs to be achieved, increasing the antibiotic therapy’s effectiveness while reducing its side effects. We have developed and characterized antimicrobial hydrogels based on an inexpensive and biocompatible natural substance from the dairy industry—whey protein isolate—as matrices for drug delivery. The release of cefazolin from the pores of hydrogel structures directly depends on the amount of the loaded drug and occurs in a prolonged manner for three days. Simultaneously with the antibiotic release, hydrogel swelling and partial degradation occurs. The WPI hydrogels absorb solvent, doubling in size in three days and retaining cefazolin throughout the duration of the experiment. The antimicrobial activity of cefazolin-loaded WPI hydrogels against Staphylococcus aureus growth is prolonged in comparison to that of the free cefazolin. The overall cytotoxic effect of cefazolin-containing WPI hydrogels is lower than that of free antibiotics. Thus, our work shows that antimicrobial WPI hydrogels are suitable candidates for local antibiotic therapy of infectious surgical sequelae.

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Section: Preparation and Characterization Of Antibacterial Wpi Hydrogelsmentioning

confidence: 99%

WPI Hydrogels with a Prolonged Drug-Release Profile for Antimicrobial Therapy

et al. 2022

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“…The polymerization of these monomers leads to the formation of semicrystalline polymers and the degree of crystallinity depends on the molecular weight and polymer processing parameters. This polymer can be degraded into nontoxic components with a controllable in-vivo degradation rate and has a long history of use in DDS and tissue engineering scaffolds [106,107]. PLA-based biopolymers are often synthesized in various modifications [98,[108][109][110].…”

Section: Poly(lactic Acid)mentioning

confidence: 99%

Progress and Prospects of Polymer-Based Drug Delivery Systems for Bone Tissue Regeneration

et al. 2020

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Despite the high regenerative capacity of bone tissue, there are some cases where bone repair is insufficient for a complete functional and structural recovery after damage. Current surgical techniques utilize natural and synthetic bone grafts for bone healing, as well as collagen sponges loaded with drugs. However, there are certain disadvantages associated with these techniques in clinical usage. To improve the therapeutic efficacy of bone tissue regeneration, a number of drug delivery systems based on biodegradable natural and synthetic polymers were developed and examined in in vitro and in vivo studies. Recent studies have demonstrated that biodegradable polymers play a key role in the development of innovative drug delivery systems and tissue engineered constructs, which improve the treatment and regeneration of damaged bone tissue. In this review, we discuss the most recent advances in the field of polymer-based drug delivery systems for the promotion of bone tissue regeneration and the physical-chemical modifications of polymers for controlled and sustained release of one or more drugs. In addition, special attention is given to recent developments on polymer nano- and microparticle-based drug delivery systems for bone regeneration.

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“… 50–52 Of note, different biological components and stimuli are necessary at the correct time and place to provide practical and complicated vascularized tissues. 53 , 54 For example, porcine lung transplantation using a decellularized lung scaffold seeded with human endothelial and epithelial cells has been reported by Zhou et al to promote angiogenesis. 55 Interestingly, a decellularized goat-lung scaffold modified with a chitosan/nanohydroxyapatite composite was utilized for other tissue investigations, such as bone regeneration.…”

Section: Introductionmentioning

confidence: 99%

Cell-Seeded Biomaterial Scaffolds: The Urgent Need for Unanswered Accelerated Angiogenesis

Shokrani¹,

Shokrani²,

Sajadi³

et al. 2022

IJN

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One of the most arduous challenges in tissue engineering is neovascularization, without which there is a lack of nutrients delivered to a target tissue. Angiogenesis should be completed at an optimal density and within an appropriate period of time to prevent cell necrosis. Failure to meet this challenge brings about poor functionality for the tissue in comparison with the native tissue, extensively reducing cell viability. Prior studies devoted to angiogenesis have provided researchers with some biomaterial scaffolds and cell choices for angiogenesis. For example, while most current angiogenesis approaches require a variety of stimulatory factors ranging from biomechanical to biomolecular to cellular, some other promising stimulatory factors have been underdeveloped (such as electrical, topographical, and magnetic). When it comes to choosing biomaterial scaffolds in tissue engineering for angiogenesis, key traits rush to mind including biocompatibility, appropriate physical and mechanical properties (adhesion strength, shear stress, and malleability), as well as identifying the appropriate biomaterial in terms of stability and degradation profile, all of which may leave essential trace materials behind adversely influencing angiogenesis. Nevertheless, the selection of the best biomaterial and cells still remains an area of hot dispute as such previous studies have not sufficiently classified, integrated, or compared approaches. To address the aforementioned need, this review article summarizes a variety of natural and synthetic scaffolds including hydrogels that support angiogenesis. Furthermore, we review a variety of cell sources utilized for cell seeding and influential factors used for angiogenesis with a concentrated focus on biomechanical factors, with unique stimulatory factors. Lastly, we provide a bottom-to-up overview of angiogenic biomaterials and cell selection, highlighting parameters that need to be addressed in future studies.

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Bioresorbable composite polymeric materials for tissue engineering applications

Cited by 30 publications

References 98 publications

WPI Hydrogels with a Prolonged Drug-Release Profile for Antimicrobial Therapy

WPI Hydrogels with a Prolonged Drug-Release Profile for Antimicrobial Therapy

Progress and Prospects of Polymer-Based Drug Delivery Systems for Bone Tissue Regeneration

Cell-Seeded Biomaterial Scaffolds: The Urgent Need for Unanswered Accelerated Angiogenesis

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