Bioremediation of decabromodiphenyl ether or benzo(a)pyrene-contaminated rice-paddy soil

Li, Han-Hsin; Chang, Shu-Chi

doi:10.1007/s11368-022-03164-5

“…Members of the Lachnospiraceae family have been linked to numerous behavior outcomes in both mice and humans, though these relationships can be quite complex and difficult to predict 73 . Furthermore, in a study of bioremediation of rice paddies polluted with BaP, Lachnospiraceae bacteria were in the top five associated with BaP removal 74 . These taxa are of interest because their relationship with zebrafish behavior do not seem to be straightforward.…”

Section: Resultsmentioning

confidence: 99%

The zebrafish gut microbiome influences benzo[a]pyrene developmental neurobehavioral toxicity

Stagaman,

Alexiev,

Sieler

et al. 2024

Sci Rep

2

0

View full text Add to dashboard Cite

Early-life exposure to environmental toxicants like Benzo[a]pyrene (BaP) is associated with several health consequences in vertebrates (i.e., impaired or altered neurophysiological and behavioral development). Although toxicant impacts were initially studied relative to host physiology, recent studies suggest that the gut microbiome is a possible target and/or mediator of behavioral responses to chemical exposure in organisms, via the gut-brain axis. However, the connection between BaP exposure, gut microbiota, and developmental neurotoxicity remains understudied. Using a zebrafish model, we determined whether the gut microbiome influences BaP impacts on behavior development. Embryonic zebrafish were treated with increasing concentrations of BaP and allowed to grow to the larval life stage, during which they underwent behavioral testing and intestinal dissection for gut microbiome profiling via high-throughput sequencing. We found that exposure affected larval zebrafish microbiome diversity and composition in a manner tied to behavioral development: increasing concentrations of BaP were associated with increased taxonomic diversity, exposure was associated with unweighted UniFrac distance, and microbiome diversity and exposure predicted larval behavior. Further, a gnotobiotic zebrafish experiment clarified whether microbiome presence was associated with BaP exposure response and behavioral changes. We found that gut microbiome state altered the relationship between BaP exposure concentration and behavioral response. These results support the idea that the zebrafish gut microbiome is a determinant of the developmental neurotoxicity that results from chemical exposure.

show abstract

“…Members of the Lachnospiraceae family have been linked to numerous behavior outcomes in both mice and humans, though these relationships can be quite complex and di cult to predict [71]. Furthermore, in a study of bioremediation of rice paddies polluted with BaP, Lachnospiraceae bacteria were in the top ve associated with BaP removal [72]. These taxa are of interest because their relationship with zebra sh behavior do not seem to be straightforward.…”

Section: Microbiome Diversity and Bap Exposure Predict Larval Behaviormentioning

confidence: 99%

The zebrafish gut microbiome influences benzo[a]pyrene developmental neurotoxicity

Stagaman,

Alexiev,

Sieler

et al. 2024

Preprint

0

View full text Add to dashboard Cite

Early-life exposure to environmental toxicants like Benzo[a]pyrene (BaP) is associated with several health consequences in vertebrates (i.e., impaired or altered neurophysiological and behavioral development). Although toxicant impacts were initially studied relative to host physiology, recent studies suggest that the gut microbiome is a possible target and/or mediator of behavioral responses to chemical exposure in organisms, via the gut-brain axis. However, the connection between BaP exposure, gut microbiota, and developmental neurotoxicity remains understudied. Using a zebrafish model, we determined whether the gut microbiome influences BaP impacts on behavior development. Embryonic zebrafish were treated with increasing concentrations of BaP and allowed to grow to the larval life stage, during which they underwent behavioral testing and intestinal dissection for gut microbiome profiling via high-throughput sequencing. We found that exposure affected larval zebrafish microbiome diversity and composition in a manner tied to behavioral development: increasing concentrations of BaP were associated with increased taxonomic diversity, exposure was associated with unweighted UniFrac distance, and microbiome diversity and exposure predicted larval behavior. Further, a gnotobiotic zebrafish experiment clarified whether microbiome presence was associated with BaP exposure response and behavioral changes. We found that gut microbiome state altered the relationship between BaP exposure concentration and behavioral response. These results support the idea that the zebrafish gut microbiome is a determinant of the developmental neurotoxicity that results from chemical exposure.

show abstract

Bacterial response to the combined pollution of benzo[a]pyrene and decabromodiphenyl ether in soil under flooding anaerobic condition

Zhang,

Wang,

Yi

et al. 2024

Journal of Hazardous Materials

0

View full text Add to dashboard Cite

Bioremediation of decabromodiphenyl ether or benzo(a)pyrene-contaminated rice-paddy soil

Cited by 4 publications

References 105 publications

The zebrafish gut microbiome influences benzo[a]pyrene developmental neurobehavioral toxicity

The zebrafish gut microbiome influences benzo[a]pyrene developmental neurobehavioral toxicity

The zebrafish gut microbiome influences benzo[a]pyrene developmental neurotoxicity

Bacterial response to the combined pollution of benzo[a]pyrene and decabromodiphenyl ether in soil under flooding anaerobic condition

Contact Info

Product

Resources

About